2023
Interactive association of posttraumatic stress disorder, apolipoprotein ε4 genotype, and age on cognitive functioning
Lawrence K, Rippey C, Welikson B, Pietrzak R, Adams T. Interactive association of posttraumatic stress disorder, apolipoprotein ε4 genotype, and age on cognitive functioning. International Journal Of Geriatric Psychiatry 2023, 38: e5888. PMID: 36757293, PMCID: PMC10168127, DOI: 10.1002/gps.5888.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderThree-way interactionCognitive functioningStress disorderOlder participantsTreatment of PTSDMain effectProbable posttraumatic stress disorderAge-related cognitive impairmentAPOE ε4U.S. military veteransApolipoprotein ε4 genotypeCognitive deficitsPsychomotor performanceAge-related associationsInteractive associationsVeterans StudyMilitary veteransCognitive impairmentPreliminary evidenceTwo-way interactionAPM performanceΕ4 carriersAnalysis of covarianceFunctioning
2017
Association Between Functional Polymorphism in Neuropeptide Y Gene Promoter rs16147 and Resilience to Traumatic Stress in US Military Veterans.
Watkins LE, Han S, Krystal JH, Southwick SM, Gelernter J, Pietrzak RH. Association Between Functional Polymorphism in Neuropeptide Y Gene Promoter rs16147 and Resilience to Traumatic Stress in US Military Veterans. The Journal Of Clinical Psychiatry 2017, 78: e1058-e1059. PMID: 29099554, DOI: 10.4088/jcp.17l11646.Peer-Reviewed Original Research
2015
Amyloid-β, Anxiety, and Cognitive Decline in Preclinical Alzheimer Disease: A Multicenter, Prospective Cohort Study
Pietrzak RH, Lim YY, Neumeister A, Ames D, Ellis KA, Harrington K, Lautenschlager NT, Restrepo C, Martins RN, Masters CL, Villemagne VL, Rowe CC, Maruff P. Amyloid-β, Anxiety, and Cognitive Decline in Preclinical Alzheimer Disease: A Multicenter, Prospective Cohort Study. JAMA Psychiatry 2015, 72: 284-291. PMID: 25629787, DOI: 10.1001/jamapsychiatry.2014.2476.Peer-Reviewed Original ResearchConceptsPreclinical Alzheimer's diseaseSubjective memory complaintsElevated anxiety symptomsVerbal memoryExecutive functionGlobal cognitionAnxiety symptomsCognitive declineCognitive changesMemory complaintsAβ statusDepressive symptomsLow anxiety groupComprehensive neuropsychological evaluationHigh anxiety groupRole of anxietyFlorbetapir F 18Visual memoryCognitive domainsVisuospatial abilitiesMild cognitive impairmentNeuropsychological evaluationCognitive functionProspective cohort studyMore rapid decline