2024
Longitudinal associations between five factor model and impulsive personality traits and PTSD symptoms: Findings from the AURORA study
Hyatt C, Reddi P, Sharpe B, Michopoulos V, van Rooij S, House S, Beaudoin F, An X, Stevens J, Zeng D, Neylan T, Clifford G, Linnstaedt S, Germine L, Bollen K, Rauch S, Haran J, Lewandowski C, Musey P, Hendry P, Sheikh S, Jones C, Punches B, Kurz M, Swor R, Hudak L, Pascual J, Seamon M, Harris E, Pearson C, Peak D, Merchant R, Domeier R, Rathlev N, Sergot P, Sanchez L, Bruce S, Miller M, Pietrzak R, Joormann J, Pizzagalli D, Sheridan J, Smoller J, Harte S, Elliott J, McLean S, Kessler R, Ressler K, Koenen K, Maples-Keller J. Longitudinal associations between five factor model and impulsive personality traits and PTSD symptoms: Findings from the AURORA study. Journal Of Research In Personality 2024, 112: 104524. DOI: 10.1016/j.jrp.2024.104524.Peer-Reviewed Original ResearchImpulsive personality traitsPTSD symptomsPersonality traitsOne-year post-traumaSevere PTSD symptomsPost-traumaFactor modelNegative urgencyLow agreeablenessLow conscientiousnessTrauma exposurePersonality assessmentPTSD riskProspective linksSymptom TotalPTSDLongitudinal associationsAURORA studyIncremental predictorNeuroticismTime pointsSymptomsTraitsAgreeablenessConscientiousnessMicroglia-mediated neuroimmune suppression in PTSD is associated with anhedonia
Bonomi R, Hillmer A, Woodcock E, Bhatt S, Rusowicz A, Angarita G, Carson R, Davis M, Esterlis I, Nabulsi N, Huang Y, Krystal J, Pietrzak R, Cosgrove K. Microglia-mediated neuroimmune suppression in PTSD is associated with anhedonia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2406005121. PMID: 39172786, PMCID: PMC11363315, DOI: 10.1073/pnas.2406005121.Peer-Reviewed Original ResearchConceptsPTSD groupPrefrontal-limbic circuitsNeuroimmune responseAssociated with anhedoniaPosttraumatic stress disorderPositron emission tomography brain imagingTranslocator protein availabilityBrain immune functionAnhedonic symptomsStress disorderPeripheral immune dysfunctionPTSDGroup differencesSeverity of symptomsPsychiatric diseasesTranslocator proteinBrain imagingAdministration of lipopolysaccharideSymptomsMicroglial markersLPS-induced increaseCompared to controlsImmune functionSickness symptomsAnhedonia
2023
Evaluating a novel 8-factor dimensional model of PTSD in U.S. military veterans: Results from the National Health and Resilience in Veterans Study
Stiltner B, Fischer I, Duek O, Polimanti R, Harpaz-Rotem I, Pietrzak R. Evaluating a novel 8-factor dimensional model of PTSD in U.S. military veterans: Results from the National Health and Resilience in Veterans Study. Journal Of Affective Disorders 2023, 346: 303-307. PMID: 37979626, DOI: 10.1016/j.jad.2023.11.041.Peer-Reviewed Original ResearchConceptsIndex traumaPTSD symptomsNational HealthPosttraumatic stress disorder (PTSD) symptomsVeterans StudyMilitary veteransTrauma-exposed populationsClinician-administered interviewU.S. military veteransConfirmatory factor analysisDSM-5 modelStrong significant associationTrauma exposureIntrusive symptomsDisorder symptomsCombat exposureHigh riskU.S. veteransDSM-5Significant associationSymptomsInterpersonal violenceFactor analysisPTSDScarce research
2022
EPIGENOME-WIDE PREDICTORS OF RESPONSE TO INTERNET-BASED COGNITIVE-BEHAVIORAL THERAPY FOR PTSD IN WORLD TRADE CENTER TRAUMA SURVIVORS
Kozik E, Kowalchyk M, Brinkman H, Desarnaud F, Yehuda R, Pietrzak R, Huckins L, Feder A. EPIGENOME-WIDE PREDICTORS OF RESPONSE TO INTERNET-BASED COGNITIVE-BEHAVIORAL THERAPY FOR PTSD IN WORLD TRADE CENTER TRAUMA SURVIVORS. European Neuropsychopharmacology 2022, 63: e130. DOI: 10.1016/j.euroneuro.2022.07.242.Peer-Reviewed Original Research
2017
Neuroeconomic approach to trauma related psychopathology: A version to ambiguous losses in PTSD
Harpaz-Rotem I, Jia R, Ruderman L, Pietrzak R, Levy I. Neuroeconomic approach to trauma related psychopathology: A version to ambiguous losses in PTSD. European Psychiatry 2017, 41: s358. DOI: 10.1016/j.eurpsy.2017.02.349.Peer-Reviewed Original ResearchAnxious arousal symptomsArousal symptomsAmbiguity attitudesCombat exposureTrauma-related symptomatologyTrauma-Related PsychopathologyTrauma-related symptomsWhole-brain analysisBehavioral economics techniquesSeverity of PTSDDisclosure of interestNeuroeconomic approachNeural underpinningsTraditional diagnostic categoriesSpecific brain areasCombat veteransRelated psychopathologyAmbiguous optionBehavioral outcomesFMRI dataBrain analysisPTSDLoss domainAmbiguous lossBrain areas