2015
Amyloid-β, Anxiety, and Cognitive Decline in Preclinical Alzheimer Disease: A Multicenter, Prospective Cohort Study
Pietrzak RH, Lim YY, Neumeister A, Ames D, Ellis KA, Harrington K, Lautenschlager NT, Restrepo C, Martins RN, Masters CL, Villemagne VL, Rowe CC, Maruff P. Amyloid-β, Anxiety, and Cognitive Decline in Preclinical Alzheimer Disease: A Multicenter, Prospective Cohort Study. JAMA Psychiatry 2015, 72: 284-291. PMID: 25629787, DOI: 10.1001/jamapsychiatry.2014.2476.Peer-Reviewed Original ResearchConceptsPreclinical Alzheimer's diseaseSubjective memory complaintsElevated anxiety symptomsVerbal memoryExecutive functionGlobal cognitionAnxiety symptomsCognitive declineCognitive changesMemory complaintsAβ statusDepressive symptomsLow anxiety groupComprehensive neuropsychological evaluationHigh anxiety groupRole of anxietyFlorbetapir F 18Visual memoryCognitive domainsVisuospatial abilitiesMild cognitive impairmentNeuropsychological evaluationCognitive functionProspective cohort studyMore rapid decline
2012
P3‐406: PET imaging of amyloid burden and cognitive assessment for the reliable discrimination between healthy aging, subjective memory impairment and mild cognitive impairment
Snyder P, Darby D, Lim Y, Fredrickson A, Pietrzak R, Rowe C, Villemagne V, Maruff P. P3‐406: PET imaging of amyloid burden and cognitive assessment for the reliable discrimination between healthy aging, subjective memory impairment and mild cognitive impairment. Alzheimer's & Dementia 2012, 8: p598-p598. DOI: 10.1016/j.jalz.2012.05.2080.Peer-Reviewed Original Research