2015
Amyloid-β, Anxiety, and Cognitive Decline in Preclinical Alzheimer Disease: A Multicenter, Prospective Cohort Study
Pietrzak RH, Lim YY, Neumeister A, Ames D, Ellis KA, Harrington K, Lautenschlager NT, Restrepo C, Martins RN, Masters CL, Villemagne VL, Rowe CC, Maruff P. Amyloid-β, Anxiety, and Cognitive Decline in Preclinical Alzheimer Disease: A Multicenter, Prospective Cohort Study. JAMA Psychiatry 2015, 72: 284-291. PMID: 25629787, DOI: 10.1001/jamapsychiatry.2014.2476.Peer-Reviewed Original ResearchConceptsPreclinical Alzheimer's diseaseSubjective memory complaintsElevated anxiety symptomsVerbal memoryExecutive functionGlobal cognitionAnxiety symptomsCognitive declineCognitive changesMemory complaintsAβ statusDepressive symptomsLow anxiety groupComprehensive neuropsychological evaluationHigh anxiety groupRole of anxietyFlorbetapir F 18Visual memoryCognitive domainsVisuospatial abilitiesMild cognitive impairmentNeuropsychological evaluationCognitive functionProspective cohort studyMore rapid decline
2014
Reliability and usability of an internet-based computerized cognitive testing battery in community-dwelling older people
Darby D, Fredrickson J, Pietrzak R, Maruff P, Woodward M, Brodtmann A. Reliability and usability of an internet-based computerized cognitive testing battery in community-dwelling older people. Computers In Human Behavior 2014, 30: 199-205. DOI: 10.1016/j.chb.2013.08.009.Peer-Reviewed Original ResearchComputerized test batteryTest batteryComputerized cognitive testing batteryCognitive declineCognitive testing batteryCommunity-dwelling older peopleOlder peopleCommunity-dwelling older adultsSelf-administered testingInternet-based versionTest-retest reliabilityCognitive functionTesting batteryOlder adultsNeurodegenerative conditionsTerms of acceptabilityEarly featureFurther evaluationTest usabilityParticipantsHigh acceptabilityBaseline testMonthly intervalsTechnical difficultiesAcceptability
2012
O3‐05‐05: Effect of Aβ burden and apolipoprotein E‐ε4 on cognitive decline at 18 months in healthy older adults
Lim Y, Ellis K, Ames D, Harrington K, Martins R, Masters C, Rowe C, Savage G, Szoeke C, Villemagne V, Pietrzak R, Maruff P, Group A. O3‐05‐05: Effect of Aβ burden and apolipoprotein E‐ε4 on cognitive decline at 18 months in healthy older adults. Alzheimer's & Dementia 2012, 8: p439-p439. DOI: 10.1016/j.jalz.2012.05.1168.Peer-Reviewed Original Research