2013
7T MR spectroscopic imaging in the localization of surgical epilepsy
Pan JW, Duckrow RB, Gerrard J, Ong C, Hirsch LJ, Resor SR, Zhang Y, Petroff O, Spencer S, Hetherington HP, Spencer DD. 7T MR spectroscopic imaging in the localization of surgical epilepsy. Epilepsia 2013, 54: 1668-1678. PMID: 23895497, PMCID: PMC3938332, DOI: 10.1111/epi.12322.Peer-Reviewed Original ResearchConceptsSevere metabolic abnormalitiesLocalization-related epilepsyMR spectroscopic imagingN-acetyl aspartateComplete resectionMetabolic abnormalitiesBetter outcomesMedial temporal lobe epilepsyResection regionTemporal lobe epilepsyNAA/CrSeizure onset zoneSurgical resectionLobe epilepsySurgical approachSeizure localizationMetabolic dysfunctionInternational LeagueSurgical epilepsyGray matterEpilepsyResectionAbnormalitiesMRSI abnormalitiesOutcome prediction
2005
Normal magnetic resonance imaging and medial temporal lobe epilepsy: the clinical syndrome of paradoxical temporal lobe epilepsy.
Cohen-Gadol AA, Bradley CC, Williamson A, Kim JH, Westerveld M, Duckrow RB, Spencer DD. Normal magnetic resonance imaging and medial temporal lobe epilepsy: the clinical syndrome of paradoxical temporal lobe epilepsy. Journal Of Neurosurgery 2005, 102: 902-9. PMID: 15926717, DOI: 10.3171/jns.2005.102.5.0902.Peer-Reviewed Original ResearchConceptsMedial temporal lobe epilepsyMedial temporal sclerosisTemporal lobe epilepsyAnteromedial temporal resectionPTLE groupDentate granule cellsLobe epilepsyMTS groupTemporal resectionClinical featuresNeuron lossSeizure historyHippocampal slicesGranule cellsNormal magnetic resonance imagingBlinded visual inspectionPyramidal cell lossDistinct clinical featuresHippocampal cell densityT2 signal changeSignificant neuron lossHippocampal volumetric measurementsMagnetic resonance imagingVolumetric measurementsSharp electrode recordings