2001
Cholinergic stimulation of rat acinar cells increases c-fos and c-jun expression via a mitogen-activated protein kinase-dependent pathway
Turner DJ, Cowles RA, Segura BJ, Mulholland MW. Cholinergic stimulation of rat acinar cells increases c-fos and c-jun expression via a mitogen-activated protein kinase-dependent pathway. Journal Of Gastrointestinal Surgery 2001, 5: 661-672. PMID: 12086906, DOI: 10.1016/s1091-255x(01)80110-4.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceBlotting, WesternCalciumCalcium SignalingCarbacholCells, CulturedCholinergic AgonistsDiaminesDose-Response Relationship, DrugEnzyme ActivationGene ExpressionMolecular Sequence DataPancreasPiperidinesPirenzepinePolymerase Chain ReactionProto-Oncogene Proteins c-fosProto-Oncogene Proteins c-junRatsReceptors, MuscarinicSensitivity and SpecificityConceptsC-jun early response geneMitogen-activated protein kinase activityProtein kinase-dependent pathwayMitogen-activated protein kinase-dependent pathwayProtein kinase activityAR42J acinar cellsEarly response genesKinase-dependent pathwayDose-dependent increaseC-fosAcetylcholine analogue carbacholC-jun expressionAcinar cellsKinase activityGene expressionM2 inhibitionRat acinar cellsMuscarinic receptor subtypes M1Enzyme activationSpecific inhibitorM3 receptor subtypePolymerase chain reaction analysisChain reaction analysisPancreatic exocrine functionIntracellular calcium releaseStimulation of rat pancreatic exocrine secretion by cocaine- and amphetamine-regulated transcript peptide
Cowles R, Segura B, Mulholland M. Stimulation of rat pancreatic exocrine secretion by cocaine- and amphetamine-regulated transcript peptide. Peptides 2001, 99: 61-68. PMID: 11257316, DOI: 10.1016/s0167-0115(01)00226-9.Peer-Reviewed Original ResearchConceptsPancreatic exocrine secretionRat pancreatic exocrine secretionAmphetamine-regulated transcript peptideEffects of CARTPeptide-induced increaseCART peptideExocrine secretionAmylase secretionTranscript peptidePancreatic secretionPancreatic aciniPancreatic secretory functionCombination of atropinePeripheral nervous systemRat pancreatic aciniAnesthetized ratsPeripheral tissuesNervous systemSecretory functionStimulatory effectSecretionAcinar unitsFour-fold increaseAtropineAcetylcholine
2000
ATP Induces c-fos Expression in C6 Glioma Cells by Activation of P2Y Receptors
Zhang W, Turner D, Segura B, Cowles R, Mulholland M. ATP Induces c-fos Expression in C6 Glioma Cells by Activation of P2Y Receptors. Journal Of Surgical Research 2000, 94: 49-55. PMID: 11038302, DOI: 10.1006/jsre.2000.5984.Peer-Reviewed Original ResearchConceptsProtein kinase CType II protein kinaseMAP kinase kinasePhosphorylated MAP kinaseType I proteinC6 glioma cellsSecond messenger pathwaysExtracellular ATP functionsC-fos mRNA expressionKinase kinaseProtein kinaseGlioma cellsMAP kinasePhospholipase C inhibitorCalmodulin kinaseI proteinKinase CKinaseATP functionsMessenger pathwaysC inhibitorMRNA expressionCellular proliferationMultifactorial regulationC-fos expressionCholinergic intrapancreatic neurons induce Ca2+ signaling and early-response gene expression in pancreatic acinar cells
Turner D, Cowles R, Segura B, Romanchuk G, Barnhart D, Mulholland M. Cholinergic intrapancreatic neurons induce Ca2+ signaling and early-response gene expression in pancreatic acinar cells. Journal Of Gastrointestinal Surgery 2000, 4: 475-480. PMID: 11077322, DOI: 10.1016/s1091-255x(00)80089-x.Peer-Reviewed Original ResearchConceptsPancreatic acinar cellsC-fos expressionIntrapancreatic neuronsAcinar cellsEarly response gene expressionPancreatic exocrine functionIntracellular calcium levelsC-Fos proteinAR42J pancreatic acinar cellsExocrine functionCholinergic stimulationNeuronal depolarizationIntracellular calciumLong-term consequencesCalcium levelsNeuronal regulationNeuronsGene expressionPancreatic lobulesCalcium signalingCellsDepolarizationExpressionAverage increaseAgonists