2022
Short Bowel Syndrome and Intestinal Lengthening Procedures
Salvi P, Cowles R. Short Bowel Syndrome and Intestinal Lengthening Procedures. 2022, 345-356. DOI: 10.1007/978-3-030-96542-6_31.ChaptersIntestinal lengthening proceduresParenteral nutritionLengthening proceduresIntestinal transplantSurgical interventionMultidisciplinary intestinal rehabilitation programParenteral nutrition failureIntestinal rehabilitation programShort bowel syndromeSmall bowel resectionSignificant physiologic consequencesCompensatory-adaptive changesBowel functionBowel resectionBowel syndromeIntestinal transitIntestinal adaptationIntestinal lossSpecialized epithelial cellsMucosal growthRehabilitation programPhysiologic consequencesDistal ileumPatientsFat absorption
2019
Orally Dosed Citalopram Stimulates Small Intestinal Mucosal Growth
Zhang L, Greig CJ, Cowles RA. Orally Dosed Citalopram Stimulates Small Intestinal Mucosal Growth. Journal Of Surgical Research 2019, 236: 326-331. PMID: 30694773, DOI: 10.1016/j.jss.2018.11.033.Peer-Reviewed Original ResearchConceptsMucosal surface areaSelective serotonin reuptake inhibitorsSerotonin reuptake inhibitorsIntestinal mucosal growthVillus heightVillus widthD citalopramReuptake inhibitorsMucosal growthCrypt depthCrypt widthSmall intestinal mucosal growthShort bowel syndromeT-testSerious intestinal disordersStudent's t-testOral agentsBowel syndromeOral therapyEnteral administrationC57BL/6 miceIleal segmentIntestinal disordersDay 21Day 7
2018
Retracing our STEPs: Four decades of progress in intestinal lengthening procedures for short bowel syndrome
Greig CJ, Oh PS, Gross ER, Cowles RA. Retracing our STEPs: Four decades of progress in intestinal lengthening procedures for short bowel syndrome. The American Journal Of Surgery 2018, 217: 772-782. PMID: 30514435, DOI: 10.1016/j.amjsurg.2018.11.025.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsShort bowel syndromeBowel syndromeReversed intestinal segmentInnovative new treatmentsBowel dilationIntestinal rehabilitationIntestinal failureBowel lengthSurgical managementBacterial overgrowthIntestinal adaptationColonic transpositionPatient outcomesSurgical techniqueLengthening surgeryIntestinal segmentsArtificial valvesNew treatmentsSyndromeCare paradigmPoor motilityBirthOutcomesTransit timeLong term
2016
Distribution of muscarinic acetylcholine receptor subtypes in the murine small intestine
Muise ED, Gandotra N, Tackett JJ, Bamdad MC, Cowles RA. Distribution of muscarinic acetylcholine receptor subtypes in the murine small intestine. Life Sciences 2016, 169: 6-10. PMID: 27866962, DOI: 10.1016/j.lfs.2016.10.030.Peer-Reviewed Original ResearchConceptsSmall intestineReceptor subtypesMuscarinic acetylcholine receptor subtypesShort bowel syndromeEffects of acetylcholineStem cell compartmentMuscarinic receptor subtypesAcetylcholine receptor subtypesSmall intestinal mucosaPotential therapeutic targetMurine small intestineCell compartmentSpecific mAChRBowel syndromeCholinergic pathwaysMyenteric plexusAnatomic distributionMuscarinic receptorsEntire alimentary tractIntestinal diseaseIntestinal mucosaEnterocyte turnoverIntestinal growthTherapeutic targetCrypt bases