2019
Potentiation of serotonin signaling leads to increased carbohydrate and lipid absorption in the murine small intestine
Park CJ, Armenia SJ, Shaughnessy MP, Greig CJ, Cowles RA. Potentiation of serotonin signaling leads to increased carbohydrate and lipid absorption in the murine small intestine. Journal Of Pediatric Surgery 2019, 54: 1245-1249. PMID: 30879746, DOI: 10.1016/j.jpedsurg.2019.02.027.Peer-Reviewed Original ResearchConceptsPotentiation of serotoninSmall intestineMucosal growthLipid absorptionSmall intestinal mucosal growthMucosal growth factorsSerotonin reuptake transporterSERT knockout miceDistal small intestineIntestinal mucosal growthCrypt cell proliferationT-testMucosal surface areaMurine small intestineStudent's t-testEnteric serotoninIntestinal failureIntestinal adaptationReuptake transporterDeficient miceWT animalsIntestinal homeostasisFatty acid analogueCrypt depthVillus height
2016
Enhanced serotonin signaling stimulates ordered intestinal mucosal growth
Tackett JJ, Gandotra N, Bamdad MC, Muise ED, Cowles RA. Enhanced serotonin signaling stimulates ordered intestinal mucosal growth. Journal Of Surgical Research 2016, 208: 198-203. PMID: 27993209, DOI: 10.1016/j.jss.2016.09.036.Peer-Reviewed Original ResearchConceptsWild-type littermatesCrypt proliferation indexSerotonin reuptake transporterEnterocyte heightCrypt depthEnhanced serotonin signaling increases intestinal neuroplasticity
Greig CJ, Gandotra N, Tackett JJ, Bamdad MC, Cowles RA. Enhanced serotonin signaling increases intestinal neuroplasticity. Journal Of Surgical Research 2016, 206: 151-158. PMID: 27916355, DOI: 10.1016/j.jss.2016.07.021.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsIntestinal mucosal growthSERT knockoutMucosal growthEnterocyte proliferationEnteric nervous systemSerotonin reuptake inhibitorsMassive bowel resectionSerotonin reuptake transporterAge-matched WTGAP-43 expressionWild-type miceSynthesis inhibitionMarkers of neuroplasticityImportant regulatorReversal of effectsEpithelial cell compartmentWestern blot analysisBowel resectionReuptake inhibitorsWT miceReuptake transporterMucosal homeostasisIntestinal segmentsCrypt depth