2023
Antibiotic-induced microbial depletion enhances murine small intestinal epithelial growth in a serotonin-dependent manner
Salvi P, Shaughnessy M, Sumigray K, Cowles R. Antibiotic-induced microbial depletion enhances murine small intestinal epithelial growth in a serotonin-dependent manner. AJP Gastrointestinal And Liver Physiology 2023, 325: g80-g91. PMID: 37158470, DOI: 10.1152/ajpgi.00113.2022.Peer-Reviewed Original ResearchConceptsSerotonin activitySERT protein expressionSerotonin potentiationEpithelial proliferationSerotonin transporterEndogenous serotoninVillus heightMicrobial depletionIntestinal epithelial growthProtein expressionEpithelial growthSerotonin-dependent mechanismIntestinal villus heightSmall intestine resultsIntestinal surface areaSmall intestinal villiSmall intestinal cryptsIntestinal pathologyPara-chlorophenylalanineISC numbersSerotonin synthesisIntestinal homeostasisEpithelial expressionMouse modelAnimal models
2019
Potentiation of serotonin signaling leads to increased carbohydrate and lipid absorption in the murine small intestine
Park CJ, Armenia SJ, Shaughnessy MP, Greig CJ, Cowles RA. Potentiation of serotonin signaling leads to increased carbohydrate and lipid absorption in the murine small intestine. Journal Of Pediatric Surgery 2019, 54: 1245-1249. PMID: 30879746, DOI: 10.1016/j.jpedsurg.2019.02.027.Peer-Reviewed Original ResearchConceptsPotentiation of serotoninSmall intestineMucosal growthLipid absorptionSmall intestinal mucosal growthMucosal growth factorsSerotonin reuptake transporterSERT knockout miceDistal small intestineIntestinal mucosal growthCrypt cell proliferationT-testMucosal surface areaMurine small intestineStudent's t-testEnteric serotoninIntestinal failureIntestinal adaptationReuptake transporterDeficient miceWT animalsIntestinal homeostasisFatty acid analogueCrypt depthVillus height