2019
Potentiated serotonin signaling in serotonin re‐uptake transporter knockout mice increases enterocyte mass and small intestinal absorptive function
Greig CJ, Zhang L, Cowles RA. Potentiated serotonin signaling in serotonin re‐uptake transporter knockout mice increases enterocyte mass and small intestinal absorptive function. Physiological Reports 2019, 7: e14278. PMID: 31724827, PMCID: PMC6854605, DOI: 10.14814/phy2.14278.Peer-Reviewed Original ResearchConceptsIntestinal absorptive functionEnterocyte massCrypt proliferation indexSmall intestineAbsorptive functionDistal bowelSmall bowelCrypt depthSERT knockoutVillus heightProliferative parametersSmall intestinal absorptive functionPlasma citrulline levelsCrypt cell proliferationPeptide absorptionSignificant increaseMucosal surface areaAttractive therapeutic targetFunctional intestinal mucosaWT miceCitrulline levelsPlasma citrullineSerotonin systemIntestinal mucosaLuminal instillation
2017
Improved capacity to evaluate changes in intestinal mucosal surface area using mathematical modeling
Greig CJ, Cowles RA. Improved capacity to evaluate changes in intestinal mucosal surface area using mathematical modeling. Microscopy Research And Technique 2017, 80: 793-798. PMID: 28295852, DOI: 10.1002/jemt.22866.Peer-Reviewed Original ResearchConceptsMucosal surface areaIntestinal mucosal surface areaVillus heightCrypt widthMucosal growthSelective serotonin reuptakeIntestinal mucosal growthEffects of interventionsFunctional intestinal mucosaEnhanced serotoninBowel diameterSerotonin reuptakeIntestinal mucosaMouse modelIleal sectionsTransporter moleculesMorphometric measuresComprehensive assessmentSSRIsMorphometric parametersMucosaSerotoninStandard measuresTherapyReuptake