2009
Expression and prognostic significance of kallikrein-related peptidase 8 protein levels in advanced ovarian cancer by using automated quantitative analysis
Kountourakis P, Psyrri A, Scorilas A, Markakis S, Kowalski D, Camp RL, Diamandis EP, Dimopoulos MA. Expression and prognostic significance of kallikrein-related peptidase 8 protein levels in advanced ovarian cancer by using automated quantitative analysis. Thrombosis And Haemostasis 2009, 101: 541-546. PMID: 19277417, DOI: 10.1160/th08-01-0052.Peer-Reviewed Original ResearchConceptsProgression-free survivalOvarian cancerPrognostic significanceSurvival analysisFive-year overall survivalPlatinum-paclitaxel combination chemotherapyYear progression-free survivalAdvanced stage ovarian cancerAdvanced ovarian cancerStage ovarian cancerMultivariate survival analysisUnivariate survival analysisImportant prognostic biomarkerSerine protease enzyme familyExpression levelsSignificant correlationWarrants further investigationProtein expression levelsKLK8 expressionClinical responseOverall survivalSurgical debulkingCombination chemotherapyPrognostic valueResidual disease
2008
Prognostic value of kallikrein‐related peptidase 6 protein expression levels in advanced ovarian cancer evaluated by automated quantitative analysis (AQUA)
Kountourakis P, Psyrri A, Scorilas A, Camp R, Markakis S, Kowalski D, Diamandis EP, Dimopoulos MA. Prognostic value of kallikrein‐related peptidase 6 protein expression levels in advanced ovarian cancer evaluated by automated quantitative analysis (AQUA). Cancer Science 2008, 99: 2224-2229. PMID: 18957059, PMCID: PMC11159123, DOI: 10.1111/j.1349-7006.2008.00942.x.Peer-Reviewed Original ResearchConceptsOvarian cancerOverall survivalPrognostic valueKLK6 expressionSurvival analysisPlatinum-paclitaxel combination chemotherapyAdvanced stage ovarian cancerAdvanced ovarian cancerProgression-free survivalProtein expressionStage ovarian cancerInferior patient outcomesUnivariate survival analysisMultivariate survival analysisImportant prognostic biomarkerSerine protease enzyme familyExpression levelsProtein expression levelsSurgical debulkingCombination chemotherapyPatient outcomesPrognostic biomarkerPrognostic variablesSufficient tissueTherapeutic targetHuman tissue kallikrein 7, a novel biomarker for advanced ovarian carcinoma using a novel in situ quantitative method of protein expression
Psyrri A, Kountourakis P, Scorilas A, Markakis S, Camp R, Diamandis E, Dimopoulos M, Kowalski D. Human tissue kallikrein 7, a novel biomarker for advanced ovarian carcinoma using a novel in situ quantitative method of protein expression. Annals Of Oncology 2008, 19: 1271-1277. PMID: 18325919, DOI: 10.1093/annonc/mdn035.Peer-Reviewed Original ResearchConceptsOvarian cancerOverall survivalProtein expressionSurvival analysisPlatinum-paclitaxel combination chemotherapyAdvanced stage ovarian cancerAdvanced ovarian carcinomaDisease-free survivalPromising prognostic factorInferior patient outcomesMultivariate survival analysisUnivariate survival analysisImportant prognostic biomarkerSerine protease enzyme familyKallikrein 7Surgical debulkingCombination chemotherapyPrognostic factorsPrognostic valueOvarian carcinomaPatient outcomesPrognostic biomarkerPrognostic variablesNovel biomarkersBetter outcomes