1996
Role of tyrosine kinase pathways in ETB receptor activation of NHE3
Chu TS, Tsuganezawa H, Peng Y, Cano A, Yanagisawa M, Alpern RJ. Role of tyrosine kinase pathways in ETB receptor activation of NHE3. American Journal Of Physiology 1996, 271: c763-c771. PMID: 8843705, DOI: 10.1152/ajpcell.1996.271.3.c763.Peer-Reviewed Original ResearchConceptsET-1-induced tyrosine phosphorylationTyrosine kinase pathwayTyrosine phosphorylationKinase pathwayFocal adhesion proteinsIntegral membrane proteinsAntiporter activityClonal cell linesFocal adhesionsMembrane proteinsReceptor activationAdhesion proteinsImmunoprecipitation studiesPhosphorylationCytochalasin DET-1-induced increaseApical membraneDependent pathwayAntiporter activationProteinPaxillinP125FAKCell linesPhosphoproteinPathway
1995
Molecular cloning of ion transporters: potential clinical implications.
Cano A, Alpern R. Molecular cloning of ion transporters: potential clinical implications. Seminars In Nephrology 1995, 15: 2-8. PMID: 7754253.Peer-Reviewed Original ResearchConceptsIon transportersIntegral membrane proteinsStructure/functionUnderstanding of functionMembrane proteinsMolecular cloningTransporter proteinsHereditary ovalocytosisProteinHyperkalemic periodic paralysisCloningGenetic disordersTransportersMyotonia congenitaMultiple levelsAbnormal structurePotential clinical implicationsPeriodic paralysisEnzymeHereditary spherocytosisRegulationOvalocytosisCystic fibrosisFunction