2024
Pharmacological management of pediatric metabolic dysfunction‐associated steatotic liver disease
Jaoudeh R, Hartmann P, Olson O, Gupta O, Kumar S, Ibrahim S, Fawaz R, Aqul A, Hassan S. Pharmacological management of pediatric metabolic dysfunction‐associated steatotic liver disease. Journal Of Pediatric Gastroenterology And Nutrition 2024 PMID: 39526564, DOI: 10.1002/jpn3.12402.Peer-Reviewed Original ResearchGLP-1RABody mass indexLiver diseasePediatric patientsPediatric obesityEfficacy of GLP-1RADisease progressionGlucagon-like peptide-1 receptor agonistsSteatotic liver diseaseManagement of pediatric patientsPeptide-1 receptor agonistsClinical management of pediatric patientsAdverse liver outcomesInduce weight lossLong-term efficacyHepatic manifestation of obesityLiver enzyme levelsAlternative therapeutic strategiesHalting disease progressionManifestation of obesityNonalcoholic fatty liver diseaseChildhood obesity ratesFatty liver diseaseReceptor agonistsLiver transplantation
2023
Food Insecurity and Pediatric Nonalcoholic Fatty Liver Disease Severity
Orkin S, Zhao X, Setchell K, Carr E, Arce-Clachar A, Bramlage K, Huang R, Fei L, Beck A, Fawaz R, Valentino P, Xanthakos S, Mouzaki M. Food Insecurity and Pediatric Nonalcoholic Fatty Liver Disease Severity. The Journal Of Pediatrics 2023, 265: 113818. PMID: 37931698, PMCID: PMC11108653, DOI: 10.1016/j.jpeds.2023.113818.Peer-Reviewed Original ResearchNonalcoholic fatty liver diseaseHousehold Food Security Survey ModuleFood Security Survey ModuleNonalcoholic fatty liver disease severityPediatric nonalcoholic fatty liver diseasePossible pathophysiologic linkLiver disease severityFatty liver diseaseBMI z-scoreCross-sectional studyFood-secure counterpartsYears of ageSurvey ModulePathophysiologic linkWarrants further explorationHistologic severityLiver diseasePathophysiologic mechanismsFood insecurityMean ageFood insecurity statusEarly presentationDisease severityZ-scorePatientsA quality improvement intervention to decrease the decline in renal function in pediatric liver transplant recipients
Batsis I, Elisofon S, Ferguson M, Jonas M, Kimball B, Lee C, Mitchell P, Fawaz R. A quality improvement intervention to decrease the decline in renal function in pediatric liver transplant recipients. Pediatric Transplantation 2023, 27: e14506. PMID: 36938904, DOI: 10.1111/petr.14506.Peer-Reviewed Original ResearchConceptsPrevalence of eGFRPost-intervention periodPediatric liver transplant recipientsYear post-LTLiver transplant recipientsChronic kidney diseasePost-LTTransplant recipientsSignificant non-modifiable risk factorNon-modifiable risk factorsChildren post-LTLong-term morbidityBlood pressure percentilesGlomerular filtration rateQuality improvement interventionsQuality improvement projectHospital dischargeRenal functionMonth 24Kidney diseaseFiltration rateRisk factorsInclusion criteriaQI interventionsMetabolic disorders
2022
Natural history of liver disease in a large international cohort of children with Alagille syndrome: Results from the GALA study
Vandriel S, Li L, She H, Wang J, Gilbert M, Jankowska I, Czubkowski P, Gliwicz‐Miedzińska D, Gonzales E, Jacquemin E, Bouligand J, Spinner N, Loomes K, Piccoli D, D'Antiga L, Nicastro E, Sokal É, Demaret T, Ebel N, Feinstein J, Fawaz R, Nastasio S, Lacaille F, Debray D, Arnell H, Fischler B, Siew S, Stormon M, Karpen S, Romero R, Kim K, Baek W, Hardikar W, Shankar S, Roberts A, Evans H, Jensen M, Kavan M, Sundaram S, Chaidez A, Karthikeyan P, Sanchez M, Cavalieri M, Verkade H, Lee W, Squires J, Hajinicolaou C, Lertudomphonwanit C, Fischer R, Larson‐Nath C, Mozer‐Glassberg Y, Arikan C, Lin H, Bernabeu J, Alam S, Kelly D, Carvalho E, Ferreira C, Indolfi G, Quiros‐Tejeira R, Bulut P, Calvo P, Önal Z, Valentino P, Desai D, Eshun J, Rogalidou M, Dezsőfi A, Wiecek S, Nebbia G, Pinto R, Wolters V, Tamara M, Zizzo A, Garcia J, Schwarz K, Beretta M, Sandahl T, Jimenez‐Rivera C, Kerkar N, Brecelj J, Mujawar Q, Rock N, Busoms C, Karnsakul W, Lurz E, Santos‐Silva E, Blondet N, Bujanda L, Shah U, Thompson R, Hansen B, Kamath B, Group T. Natural history of liver disease in a large international cohort of children with Alagille syndrome: Results from the GALA study. Hepatology 2022, 77: 512-529. PMID: 36036223, PMCID: PMC9869940, DOI: 10.1002/hep.32761.Peer-Reviewed Original ResearchConceptsNative liver survivalLarge international cohortAlagille syndromeInternational cohortNLS rateNative liverLiver diseaseMedian total bilirubin levelsEvent-free survival rateNatural historyEarly biochemical predictorsEvident portal hypertensionLiver-related eventsRisks of transplantationMulticenter retrospective studyTotal bilirubin levelsEvaluation of therapyMonths of ageGALA studyHepatic outcomesLiver survivalPortal hypertensionTertiary centerBilirubin levelsRetrospective studyAcute Hepatitis of Unknown Origin in Children: Early Observations from the 2022 Outbreak
Zhang LY, Huang LS, Yue YH, Fawaz R, Lim JK, Fan JG. Acute Hepatitis of Unknown Origin in Children: Early Observations from the 2022 Outbreak. Journal Of Clinical And Translational Hepatology 2022, 10: 522-530. PMID: 35836761, PMCID: PMC9240245, DOI: 10.14218/jcth.2022.00281.Peer-Reviewed Original ResearchAcute hepatitisSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Unknown originRespiratory syndrome coronavirus 2Serum aminotransaminase levelsAcute liver failureIU/LSyndrome coronavirus 2Immune cell activationAminotransaminase levelsGastrointestinal symptomsLiver transplantationLiver failureCoronavirus 2Healthy childrenNegative testCell activationHepatitisCOVID-19 pandemicChildrenRecent reportsEarlier observationsOutbreakCauseComparing Serum Matrix Metalloproteinase-7 in Parenteral Nutrition-Associated Liver Disease and Biliary Atresia
Salvi PS, Fawaz R, Cowles RA. Comparing Serum Matrix Metalloproteinase-7 in Parenteral Nutrition-Associated Liver Disease and Biliary Atresia. The Journal Of Pediatrics 2022, 249: 97-100. PMID: 35714967, DOI: 10.1016/j.jpeds.2022.06.014.Peer-Reviewed Original ResearchConceptsBiliary atresiaLiver diseaseParenteral nutrition-associated liver diseaseParenteral Nutrition–Associated Liver DiseaseMetalloproteinase-7Matrix metalloproteinase 7 levelsSerum matrix metalloproteinase-7Cross-sectional studyMatrix metalloproteinase-7Parenteral nutritionInvasive testingAtresiaInfantsDiseaseJaundice
2021
Liver Pathology, Including MOC31 Immunohistochemistry, in Congenital Tufting Enteropathy
Chen S, Goldsmith J, Fawaz R, Al-Ibraheemi A, Perez-Atayde A, Vargas S. Liver Pathology, Including MOC31 Immunohistochemistry, in Congenital Tufting Enteropathy. The American Journal Of Surgical Pathology 2021, 45: 1091-1097. PMID: 33756496, DOI: 10.1097/pas.0000000000001710.Peer-Reviewed Original ResearchConceptsCTE patientsCongenital tufting enteropathyParenteral nutritionBiliary epitheliumDuctular reactionLiver pathologyChronic hepatitis CHepatitis C patientsEpithelial cell adhesion moleculeLiver core biopsyIntestinal villous atrophyNormal brush borderClinicopathologic materialEpCAM-deficientCore biopsyTufting enteropathyC patientsEpCAM mutationsCell adhesion moleculesHepatitis CLiver biopsyMOC31Affected patientsLobular inflammationPathological findings75 Acute and Chronic Hepatitis
Fawaz R, Jonas M. 75 Acute and Chronic Hepatitis. 2021, 819-837.e6. DOI: 10.1016/b978-0-323-67293-1.00075-x.Peer-Reviewed Original ResearchChronic hepatitisLiver biopsyHepatocellular carcinomaHepatitis B virus infectionAcute hepatitis CChronic hepatitis BB virus infectionPerinatal transmission rateGrade of inflammationAutoimmune hepatitisJaundice 3Transplantation 2Hepatitis CHepatitis BClinical courseHepatitis ANonalcoholic steatohepatitisHistologic featuresPersistent elevationViremia levelsPrimary indicationInfection 5Hepatic damageFamily historyVirus infection
2019
Internal surgical drainage for bile lakes following hepatoportoenterostomy for biliary atresia
Dee E, Zendejas B, Fawaz R, Kim H. Internal surgical drainage for bile lakes following hepatoportoenterostomy for biliary atresia. Journal Of Pediatric Surgery Case Reports 2019, 43: 71-73. DOI: 10.1016/j.epsc.2019.02.015.Peer-Reviewed Original ResearchBile lakesBiliary atresiaBiliary cystic lesionsInternal surgical drainageResolution of jaundiceRecurrence of symptomsTime of diagnosisViable surgical optionCholangitis episodesPrevious portoenterostomyAntibiotic prophylaxisLiver transplantationRecurrent cholangitisSurgical drainagePercutaneous drainageRoux limbSurgical optionsCystic lesionsBile flowHepatoportoenterostomyPatientsCholangitisInternal drainageJaundiceCystjejunostomy
2011
75 Acute and Chronic Hepatitis
Fawaz R, Jonas M. 75 Acute and Chronic Hepatitis. 2011, 811-828.e5. DOI: 10.1016/b978-1-4377-0774-8.10075-2.Peer-Reviewed Original Research
2010
Hepatitis D and Hepatitis E in Children
Fawaz R. Hepatitis D and Hepatitis E in Children. Clinical Gastroenterology 2010, 89-110. DOI: 10.1007/978-1-60761-373-2_6.Peer-Reviewed Original ResearchHepatitis DHepatitis EClinical presentationD virusAcute hepatitis EChronic hepatitis DHepatitis D virusHepatitis B virusHDV infectionHEV vaccineIcteric hepatitisUniversal vaccinationHepatitis BViral hepatitisAsymptomatic infectionB virusEffective therapyRapid progressionHepatocellular carcinomaE therapySimultaneous infectionInfectionHepatitisVirusDefective virus