NLRX1 Deletion Increases Ischemia-Reperfusion Damage and Activates Glucose Metabolism in Mouse Heart
Zhang H, Xiao Y, Nederlof R, Bakker D, Zhang P, Girardin SE, Hollmann MW, Weber NC, Houten SM, van Weeghel M, Kibbey RG, Zuurbier CJ. NLRX1 Deletion Increases Ischemia-Reperfusion Damage and Activates Glucose Metabolism in Mouse Heart. Frontiers In Immunology 2020, 11: 591815. PMID: 33362773, PMCID: PMC7759503, DOI: 10.3389/fimmu.2020.591815.Peer-Reviewed Original ResearchConceptsIschemia-reperfusion injuryNOD-like receptorsMouse heartsKO heartsGlucose metabolismCardiac ischemia-reperfusion injuryIschemia-reperfusion damageMin of reperfusionCardiac IR injurySurvival pathwaysPro-inflammatory memberCardiac glucose metabolismInnate immune systemCardiac oxygen consumptionFatty acid oxidationInflammatory parametersPyruvate dehydrogenase fluxIR injuryEarly reperfusionInflammatory mediatorsMin reperfusionSevere ischemiaC-palmitateImmune systemReperfusion