2022
tRNA-m1A modification promotes T cell expansion via efficient MYC protein synthesis
Liu Y, Zhou J, Li X, Zhang X, Shi J, Wang X, Li H, Miao S, Chen H, He X, Dong L, Lee GR, Zheng J, Liu RJ, Su B, Ye Y, Flavell RA, Yi C, Wu Y, Li HB. tRNA-m1A modification promotes T cell expansion via efficient MYC protein synthesis. Nature Immunology 2022, 23: 1433-1444. PMID: 36138184, DOI: 10.1038/s41590-022-01301-3.Peer-Reviewed Original ResearchConceptsCell expansionKey functional proteinsVivo physiological roleDe novo protein productionCell cycle arrestTranslational controlRNA modificationsMyc proteinFunctional proteinsTranslation efficiencyKey proteinsCell homeostasisProtein productionPhysiological roleProtein synthesisProliferative stateCycle arrestConditional deletionT cell homeostasisNaive T cellsProteinQuiescent stateSpecific subsetT cellsCells
2019
To Code or Not to Code: What Is the Linc?
Flavell R. To Code or Not to Code: What Is the Linc? The FASEB Journal 2019, 33: 218.1-218.1. DOI: 10.1096/fasebj.2019.33.1_supplement.218.1.Peer-Reviewed Original ResearchNon-canonical proteinsNon-protein codingNon-coding RNAsUnbiased transcriptomics approachMammalian proteinsNovel ORFsRibosome associationUndiscovered proteinsTranscriptomic approachMethionine codonDistinct proteinsFunctional proteinsImportant transcriptsORFProteinEssential roleGenomeAbsolute requirementFASEB JournalGenesRNABacterial infectionsProteinaceous productsMisannotationsCodon