2023
Relationships of in vivo brain norepinephrine transporter and age, BMI, and gender
Koohsari S, Sadabad F, Pittman B, Gallezot J, Carson R, van Dyck C, Li C, Potenza M, Matuskey D. Relationships of in vivo brain norepinephrine transporter and age, BMI, and gender. Synapse 2023, 77: e22279. PMID: 37382240, PMCID: PMC10416616, DOI: 10.1002/syn.22279.Peer-Reviewed Original ResearchConceptsBody mass indexMultilinear reference tissue model 2Gender-related differencesBrain norepinephrine transportersNorepinephrine transporterAge-related declineStructural MR scansBrain regionsReference tissue model 2Mass indexRaphe nucleusLocus coeruleusOccipital cortexBMI relationshipHealthy adultsHigh-resolution research tomographAvailable radiotracersHealthy participantsMR scansAgeAnatomic templateReference regionNegative associationNet availabilityPotential age
2012
In Vivo Imaging of Endogenous Pancreatic β-Cell Mass in Healthy and Type 1 Diabetic Subjects Using 18F-Fluoropropyl-Dihydrotetrabenazine and PET
Normandin MD, Petersen KF, Ding YS, Lin SF, Naik S, Fowles K, Skovronsky DM, Herold KC, McCarthy TJ, Calle RA, Carson RE, Treadway JL, Cline GW. In Vivo Imaging of Endogenous Pancreatic β-Cell Mass in Healthy and Type 1 Diabetic Subjects Using 18F-Fluoropropyl-Dihydrotetrabenazine and PET. Journal Of Nuclear Medicine 2012, 53: 908-916. PMID: 22573821, PMCID: PMC3737743, DOI: 10.2967/jnumed.111.100545.Peer-Reviewed Original ResearchConceptsType 1 diabetes mellitusVesicular monoamine transporter type 2Pancreatic β-cell massStandardized uptake valueΒ-cell massDiabetes mellitusUptake valueType 1 diabetic subjectsΒ-cell densityHealthy control subjectsInsulin secretion capacityΒ-cell functionPathophysiology of diabetesTransporter type 2Nondisplaceable uptakeDiabetic subjectsControl subjectsDisease progressionClinical assessmentVMAT2 bindingRenal cortexTotal pancreasDTBZ PETEarly diagnosisInjected dose
1995
Physiological activation of a cortical network during performance of the Wisconsin Card Sorting Test: A positron emission tomography study
Berman K, Ostrem J, Randolph C, Gold J, Goldberg T, Coppola R, Carson R, Herscovitch P, Weinberger D. Physiological activation of a cortical network during performance of the Wisconsin Card Sorting Test: A positron emission tomography study. Neuropsychologia 1995, 33: 1027-1046. PMID: 8524452, DOI: 10.1016/0028-3932(95)00035-2.Peer-Reviewed Original ResearchConceptsWisconsin Card Sorting TestDorsolateral prefrontal cortexCard Sorting TestSorting TestSensorimotor control taskPhysiological activationInferior parietal lobuleInferior temporal cortexCognitive operationsPrefrontal lesionsMemory componentsNeuropsychological testsVisual associationParietal lobulePositron emission tomographyPrefrontal cortexNeural circuitryControl taskCortical networksTemporal cortexWCST activationExperiential phenomenaFrontal cortexPositron emission tomography studyRegional cerebral blood flow
1992
PET imaging of opiate receptor binding in human epilepsy using [18F]cyclofoxy
Theodore W, Carson R, Andreasen P, Zametkin A, Blasberg R, Leiderman D, Rice K, Newman A, Channing M, Dunn B, Simpson N, Herscovitch P. PET imaging of opiate receptor binding in human epilepsy using [18F]cyclofoxy. Epilepsy Research 1992, 13: 129-139. PMID: 1334456, DOI: 10.1016/0920-1211(92)90068-5.Peer-Reviewed Original ResearchConceptsComplex partial seizuresEEG fociBasal gangliaTemporal lobeBrain regionsPotent opiate antagonistMesial temporal lobeCerebral blood flowOpiate receptor bindingEEG-video monitoringLateral temporal cortexLow specific bindingSpecific bindingPartial seizuresTime-activity dataKappa receptorsOpiate antagonistEpileptic focusHuman epilepsyFrontal cortexIndividual patientsOccipital lobeMean VTBlood flowBlood samples
1985
Alternative Statistical Models for the Examination of Clinical Positron Emission Tomography/Fluorodeoxyglucose Data
Clark C, Carson R, Kessler R, Margolin R, Buchsbaum M, DeLisi L, King C, Cohen R. Alternative Statistical Models for the Examination of Clinical Positron Emission Tomography/Fluorodeoxyglucose Data. Cerebrovascular And Brain Metabolism Reviews 1985, 5: 142-150. PMID: 3871782, DOI: 10.1038/jcbfm.1985.18.Peer-Reviewed Original Research