Featured Publications
Quantification of Amphetamine-Induced Changes in [11C] Raclopride Binding with Continuous Infusion
Carson R, Breier* A, de Bartolomeis* A, Saunders† R, Su* T, Schmall B, Der M, Pickar* D, Eckelman W. Quantification of Amphetamine-Induced Changes in [11C] Raclopride Binding with Continuous Infusion. Cerebrovascular And Brain Metabolism Reviews 1997, 17: 437-447. PMID: 9143226, DOI: 10.1097/00004647-199704000-00009.Peer-Reviewed Original Research
2016
OCD is associated with an altered association between sensorimotor gating and cortical and subcortical 5-HT1b receptor binding
Pittenger C, Adams TG, Gallezot JD, Crowley MJ, Nabulsi N, Ropchan J, Gao H, Kichuk SA, Simpson R, Billingslea E, Hannestad J, Bloch M, Mayes L, Bhagwagar Z, Carson RE. OCD is associated with an altered association between sensorimotor gating and cortical and subcortical 5-HT1b receptor binding. Journal Of Affective Disorders 2016, 196: 87-96. PMID: 26919057, PMCID: PMC4808438, DOI: 10.1016/j.jad.2016.02.021.Peer-Reviewed Original ResearchConceptsPrepulse inhibitionObsessive-compulsive disorderReceptor availabilitySensorimotor gatingOCD patientsImpaired sensorimotor gatingOCD-like behaviorNon-depressed OCD patientsPositron emission tomographyBasal gangliaSerotonergic regulationHealthy controlsSerotonin systemPositive correlationWidespread positive correlationsDiagnostic groupsCortical regionsEmission tomographyOrbitofrontal cortexPatientsReceptor bindingOCD diagnosisSignificant correlationSignificant main effectImportant alterations
2002
Strategies to Improve Neuroreceptor Parameter Estimation by Linear Regression Analysis
Ichise M, Toyama H, Innis RB, Carson RE. Strategies to Improve Neuroreceptor Parameter Estimation by Linear Regression Analysis. Cerebrovascular And Brain Metabolism Reviews 2002, 22: 1271-1281. PMID: 12368666, DOI: 10.1097/01.wcb.0000038000.34930.4e.Peer-Reviewed Original Research
1999
Opiate receptor avidity is reduced bilaterally in rhesus monkeys unilaterally lesioned with MPTP
Cohen R, Carson R, Wyatt R, Doudet D. Opiate receptor avidity is reduced bilaterally in rhesus monkeys unilaterally lesioned with MPTP. Synapse 1999, 33: 282-288. PMID: 10421709, DOI: 10.1002/(sici)1098-2396(19990915)33:4<282::aid-syn5>3.0.co;2-5.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsBasal GangliaBrainCerebellumCerebral CortexDihydroxyphenylalanineFluorine RadioisotopesFunctional LateralityInfusions, ParenteralLimbic SystemMacaca mulattaNaltrexoneNarcotic AntagonistsOrgan SpecificityReceptors, OpioidReceptors, Opioid, kappaReceptors, Opioid, muTomography, Emission-ComputedConceptsOpiate receptor avidityPositron emission tomographyReceptor avidityKappa-opiate receptor antagonistInitial clinical manifestationBasal ganglia functionBasal ganglia circuitsParkinsonian animalsParkinsonian symptomsAnterior putamenClinical manifestationsDopamine innervationGanglia functionReceptor antagonistInternal carotidGanglia circuitsTreatment responsivenessOpiate pathwaysParkinson's diseaseNormal controlsMild lossEmission tomographyRhesus monkeysPET studiesMPTP