Opiate receptor avidity is reduced bilaterally in rhesus monkeys unilaterally lesioned with MPTP
Cohen R, Carson R, Wyatt R, Doudet D. Opiate receptor avidity is reduced bilaterally in rhesus monkeys unilaterally lesioned with MPTP. Synapse 1999, 33: 282-288. PMID: 10421709, DOI: 10.1002/(sici)1098-2396(19990915)33:4<282::aid-syn5>3.0.co;2-5.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsBasal GangliaBrainCerebellumCerebral CortexDihydroxyphenylalanineFluorine RadioisotopesFunctional LateralityInfusions, ParenteralLimbic SystemMacaca mulattaNaltrexoneNarcotic AntagonistsOrgan SpecificityReceptors, OpioidReceptors, Opioid, kappaReceptors, Opioid, muTomography, Emission-ComputedConceptsOpiate receptor avidityPositron emission tomographyReceptor avidityKappa-opiate receptor antagonistInitial clinical manifestationBasal ganglia functionBasal ganglia circuitsParkinsonian animalsParkinsonian symptomsAnterior putamenClinical manifestationsDopamine innervationGanglia functionReceptor antagonistInternal carotidGanglia circuitsTreatment responsivenessOpiate pathwaysParkinson's diseaseNormal controlsMild lossEmission tomographyRhesus monkeysPET studiesMPTP