2024
Large human cohort study of markerless head motion tracking for brain PET
Zeng T, Zhang J, Gallezot J, Fontaine K, Gravel P, Jiang W, Mulnix T, Yang Z, Zhang X, Hu L, Carson R. Large human cohort study of markerless head motion tracking for brain PET. 2024, 00: 1-2. DOI: 10.1109/nss/mic/rtsd57108.2024.10656091.Peer-Reviewed Original ResearchPost-reconstruction registrationEvent-by-eventBrain PET imagingMotion correction techniqueQuantitative PET imagingPET imagingBrain PETHead motionTime activity curvesStudy of brain functionImage qualityMotion tracking systemGray matter regionsCorrection techniqueMotionHuman cohort studiesAverage SUVPET measurementsMotion blurMatter regionsSuperior performanceTracking systemPolaris
2016
Synthesis and Preclinical Evaluation of 11C-UCB-J as a PET Tracer for Imaging the Synaptic Vesicle Glycoprotein 2A in the Brain
Nabulsi N, Mercier J, Holden D, Carré S, Najafzadeh S, Vandergeten MC, Lin SF, Deo A, Price N, Wood M, Lara-Jaime T, Montel F, Laruelle M, Carson RE, Hannestad J, Huang Y. Synthesis and Preclinical Evaluation of 11C-UCB-J as a PET Tracer for Imaging the Synaptic Vesicle Glycoprotein 2A in the Brain. Journal Of Nuclear Medicine 2016, 57: 777-784. PMID: 26848175, DOI: 10.2967/jnumed.115.168179.Peer-Reviewed Original ResearchConceptsSynaptic vesicle glycoprotein 2AWhole-body biodistributionPET radiotracersNonhuman primatesDose-limiting organHigher free fractionGray matter regionsBaseline VTNondisplaceable distribution volumeAntiepileptic drugsVitro inhibition constantSynaptic densityPreclinical evaluationMonkey brainDistribution volumeArterial samplingEndocrine cellsRegional volumesMatter regionsRhesus macaquesPET tracersUCBFree fractionBrainTarget occupancy