2022
CD74 ablation rescues type 2 diabetes mellitus-induced cardiac remodeling and contractile dysfunction through pyroptosis-evoked regulation of ferroptosis
Chen L, Yin Z, Qin X, Zhu X, Chen X, Ding G, Sun D, Wu NN, Fei J, Bi Y, Zhang J, Bucala R, Ren J, Zheng Q. CD74 ablation rescues type 2 diabetes mellitus-induced cardiac remodeling and contractile dysfunction through pyroptosis-evoked regulation of ferroptosis. Pharmacological Research 2022, 176: 106086. PMID: 35033649, DOI: 10.1016/j.phrs.2022.106086.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsAntigens, Differentiation, B-LymphocyteCell LineDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2FemaleFerroptosisGene ExpressionHistocompatibility Antigens Class IIHumansMacrophage Migration-Inhibitory FactorsMaleMice, KnockoutMiddle AgedMyocardial ContractionMyocardiumNLR Family, Pyrin Domain-Containing 3 ProteinOxidative StressOxygen ConsumptionPyroptosisRatsVentricular RemodelingConceptsHigh glucose/high fatMacrophage migration inhibitory factorCardiac remodelingContractile dysfunctionCell death domainGene Ontology termsInhibitors of MIFRecombinant macrophage migration inhibitory factorCytokine macrophage migration inhibitory factorType 2 diabetes mellitusOntology termsDeath domainLipid peroxidationGlobal metabolic defectsKEGG analysisPlasma MIF levelsInjection of streptozotocinMitochondrial defectsHigh-fat dietMigration inhibitory factorInhibitor of NLRP3Cell deathPrecise interplayMitochondrial dysfunctionCognate receptors
2021
ICBP90 Regulates MIF Expression, Glucocorticoid Sensitivity, and Apoptosis at the MIF Immune Susceptibility Locus
Yao J, Leng L, Fu W, Li J, Bronner C, Bucala R. ICBP90 Regulates MIF Expression, Glucocorticoid Sensitivity, and Apoptosis at the MIF Immune Susceptibility Locus. Arthritis & Rheumatology 2021, 73: 1931-1942. PMID: 33844457, DOI: 10.1002/art.41753.Peer-Reviewed Original ResearchMeSH KeywordsAllelesApoptosisCCAAT-Enhancer-Binding ProteinsCell LineFibroblastsGene Expression RegulationGenetic LociGenetic Predisposition to DiseaseGenotypeGlucocorticoidsHumansIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsPromoter Regions, GeneticReceptors, GlucocorticoidUbiquitin-Protein LigasesConceptsMacrophage migration inhibitory factorAutoimmune disease severityMIF -794 CATTRheumatoid synovial fibroblastsMIF expressionGlucocorticoid receptorGlucocorticoid sensitivitySynovial fibroblastsT cellsDisease severityPeripheral blood T cellsBlood T cellsMigration inhibitory factorGlucocorticoid-treated cellsAP-1Glucocorticoid immunosuppressionMIF promoterMIF genotypeMIF polymorphismsFactor antibodyInflammatory responseT lymphocytesActivator protein-1Glucocorticoid responsivenessInhibitory factor
2000
The proinflammatory mediator macrophage migration inhibitory factor induces glucose catabolism in muscle
Benigni F, Atsumi T, Calandra T, Metz C, Echtenacher B, Peng T, Bucala R. The proinflammatory mediator macrophage migration inhibitory factor induces glucose catabolism in muscle. Journal Of Clinical Investigation 2000, 106: 1291-1300. PMID: 11086030, PMCID: PMC381433, DOI: 10.1172/jci9900.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineCell MovementFructosediphosphatesGlucoseGlycolysisHumansLactic AcidLiverMacrophage Migration-Inhibitory FactorsMacrophagesMiceMusclesPhosphofructokinase-2Phosphoric Monoester HydrolasesPhosphotransferases (Alcohol Group Acceptor)RatsTumor Cells, CulturedTumor Necrosis Factor-alphaConceptsMacrophage migration inhibitory factorMigration inhibitory factorTNF-alphaInhibitory factorTNF-alpha knockout miceMediator macrophage migration inhibitory factorAddition of MIFSystemic inflammatory responseSevere metabolic derangementProinflammatory cytokine productionSerum glucose levelsImmune cell activationAnterior pituitary glandPositive allosteric regulatorMetabolic derangementsAutocrine stimuliCytokine productionGlucose disposalImmune cellsSevere infectionsCatabolic effectsInflammatory responseGlucose levelsInsulin releaseCatabolic response
1998
Epitopes close to the apolipoprotein B low density lipoprotein receptor-binding site are modified by advanced glycation end products
Wang X, Bucala R, Milne R. Epitopes close to the apolipoprotein B low density lipoprotein receptor-binding site are modified by advanced glycation end products. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 7643-7647. PMID: 9636203, PMCID: PMC22709, DOI: 10.1073/pnas.95.13.7643.Peer-Reviewed Original ResearchConceptsAdvanced glycation end productsLow-density lipoproteinGlycation end productsLDL receptorAGE modificationAbnormal lipoprotein profilesGlycation of LDLInability of LDLPrevious immunochemical studiesRenal failureLipoprotein profileTime-dependent decreaseCardiovascular diseaseApolipoprotein BAdvanced glycationDensity lipoproteinReceptor-binding siteEnd productsImmunochemical studiesEpitopesGlycationCellular uptakeMultiple sitesPatientsDiabetes
1997
Molecular Characterization of a Mouse Genomic Element Mobilized by Advanced Glycation Endproduct Modified-DNA (AGE-DNA)
Pushkarsky T, Rourke L, Spiegel L, Seldin M, Bucala R. Molecular Characterization of a Mouse Genomic Element Mobilized by Advanced Glycation Endproduct Modified-DNA (AGE-DNA). Molecular Medicine 1997, 3: 740-749. PMID: 9407550, PMCID: PMC2230240, DOI: 10.1007/bf03401712.Peer-Reviewed Original ResearchInsulin secretion is regulated by the glucose-dependent production of islet β cell macrophage migration inhibitory factor
Waeber G, Calandra T, Roduit R, Haefliger J, Bonny C, Thompson N, Thorens B, Temler E, Meinhardt A, Bacher M, Metz C, Nicod P, Bucala R. Insulin secretion is regulated by the glucose-dependent production of islet β cell macrophage migration inhibitory factor. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 4782-4787. PMID: 9114069, PMCID: PMC20802, DOI: 10.1073/pnas.94.9.4782.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorMigration inhibitory factorInsulin releaseInsulin secretionBeta cellsRecombinant macrophage migration inhibitory factorInhibitory factorGlucose-induced insulin releasePancreatic islet beta cellsInsulin-secreting beta cellsINS-1 cell lineIslet beta cellsIsolated rat isletsInsulin secretion responseIslets of LangerhansConcentration-dependent mannerIslet cell productsImmune cellsT lymphocytesPituitary hormonesPerifusion studiesAutocrine fashionRat isletsSecretion responseGlucocorticoid stimulation
1995
Localization of Macrophage Migration Inhibitory Factor (MIF) to Secretory Granules within the Corticotrophic and Thyrotrophic Cells of the Pituitary Gland
Nishino T, Bernhagen J, Shiiki H, Calandra T, Dohi K, Bucala R. Localization of Macrophage Migration Inhibitory Factor (MIF) to Secretory Granules within the Corticotrophic and Thyrotrophic Cells of the Pituitary Gland. Molecular Medicine 1995, 1: 781-788. PMID: 8612200, PMCID: PMC2230018, DOI: 10.1007/bf03401892.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorRelease of MIFCorticotropin-releasing hormoneMigration inhibitory factorAnterior pituitary glandPituitary glandThyrotrophic cellsBackgroundMacrophage migration inhibitory factorInhibitory factorCorticotrophic cellsAnterior pituitary hormonesActivated T lymphocytesHormone-specific antibodiesSubsets of granulesGlucocorticoid suppressionSeptic shockLPS injectionCytokine productionEndotoxin administrationACTH releaseT lymphocytesConclusionsThese dataPituitary hormonesPituitary contentHost responseMIF as a glucocorticoid-induced modulator of cytokine production
Calandra T, Bernhagen J, Metz C, Spiegel L, Bacher M, Donnelly T, Cerami A, Bucala R. MIF as a glucocorticoid-induced modulator of cytokine production. Nature 1995, 377: 68-71. PMID: 7659164, DOI: 10.1038/377068a0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternCell LineCytokinesDexamethasoneEnzyme-Linked Immunosorbent AssayFemaleGlucocorticoidsHumansHydrocortisoneImmunityInflammationLipopolysaccharidesMacrophage ActivationMacrophage Migration-Inhibitory FactorsMacrophagesMiceMice, Inbred BALB CRatsRats, Sprague-DawleyRecombinant ProteinsShock, SepticT-LymphocytesConceptsMacrophage migration inhibitory factorCounter-regulatory systemsMigration inhibitory factorProtein macrophage migration inhibitory factorGlucocorticoid protectionLethal endotoxaemiaMIF productionCytokine productionCytokine secretionMacrophage cytokinesEndogenous mediatorsImmunosuppressive propertiesImmune responseGlucocorticoid hormonesInhibitory factorHormonal systemsCritical mediatorUnexpected findingMediatorsVital functionsEndotoxaemiaCytokinesGlucocorticoidsMonocytesPituitaryAn Inhibitor of Macrophage Arginine Transport and Nitric Oxide Production (CNI-1493) Prevents Acute Inflammation and Endotoxin Lethality
Bianchi M, Ulrich P, Bloom O, Meistrell M, Zimmerman G, Schmidtmayerova H, Bukrinsky M, Donnelley T, Bucala R, Sherry B, Manogue K, Tortolani A, Cerami A, Tracey K. An Inhibitor of Macrophage Arginine Transport and Nitric Oxide Production (CNI-1493) Prevents Acute Inflammation and Endotoxin Lethality. Molecular Medicine 1995, 1: 254-266. PMID: 8529104, PMCID: PMC2229913, DOI: 10.1007/bf03401550.Peer-Reviewed Original ResearchConceptsNitric oxide synthaseL-arginine transportNO productionInflammatory responseBlood vesselsEndotoxin lethalityEDRF activityL-arginineArginine transportInhibitor of NOSLethal LPS challengeSystemic inflammatory responseNitric oxide productionSelective inhibitorDevelopment of carrageenanProduction of NOBackgroundNitric oxideEDRF responseMurine macrophage-like cell lineTetravalent guanylhydrazoneFootpad inflammationImportant homeostatic mechanismAcute inflammationLPS challengeMacrophage-like cell line