2000
Regulation of macrophage migration inhibitory factor by endogenous glucocorticoids in rat adjuvant‐induced arthritis
Leech M, Metz C, Bucala R, MorAnd E. Regulation of macrophage migration inhibitory factor by endogenous glucocorticoids in rat adjuvant‐induced arthritis. Arthritis & Rheumatism 2000, 43: 827-833. PMID: 10765927, DOI: 10.1002/1529-0131(200004)43:4<827::aid-anr13>3.0.co;2-k.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorEnzyme-linked immunosorbent assaySerum MIF levelsMigration inhibitory factorMIF levelsEndogenous glucocorticoidsADX ratsSham operationRegulation of MIFInhibitory factorIsotype-matched control antibodyTumor necrosis factor alphaAdjuvant arthritis inductionClinical disease parametersReversal of diseaseNecrosis factor alphaSites of inflammationArthritis inductionArthritis developmentMIF productionMIF releaseControl antibodyInflammatory diseasesSignificant exacerbationSupernatant levels
1998
Involvement of macrophage migration inhibitory factor in the evolution of rat adjuvant arthritis
Leech M, Metz C, Santos L, Peng T, Holdsworth S, Bucala R, Morand E. Involvement of macrophage migration inhibitory factor in the evolution of rat adjuvant arthritis. Arthritis & Rheumatism 1998, 41: 910-917. PMID: 9588744, DOI: 10.1002/1529-0131(199805)41:5<910::aid-art19>3.0.co;2-e.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalArthritis, ExperimentalBlotting, WesternCell CountCells, CulturedDose-Response Relationship, DrugEdemaEnzyme-Linked Immunosorbent AssayImmunohistochemistryMacrophage Migration-Inhibitory FactorsMacrophagesMaleNeutralization TestsRatsRats, Sprague-DawleySynovial MembraneConceptsMacrophage migration inhibitory factorRat adjuvant arthritisAdjuvant arthritisMigration inhibitory factorSynovial macrophagesRat synoviumLevels of MIFRole of MIFInhibitory factorMonoclonal antibodiesArthritis clinical scoresT cell accumulationDose-dependent inhibitionEnzyme-linked immunosorbentMIF treatmentAdjuvant injectionMAb treatmentClinical scoresED-1Leukocyte numbersSpecific monoclonal antibodiesClinical aspectsT cellsArthritisMacrophage activation