2023
A pref-1-controlled non-inflammatory mechanism of insulin resistance
Huang Y, Cui D, Chen L, Tong H, Wu H, Muller G, Qi Y, Wang S, Xu J, Gao X, Fifield K, Wang L, Xia Z, Vanderluit J, Liu S, Leng L, Sun G, McGuire J, Young L, Bucala R, Qi D. A pref-1-controlled non-inflammatory mechanism of insulin resistance. IScience 2023, 26: 106923. PMID: 37283810, PMCID: PMC10239698, DOI: 10.1016/j.isci.2023.106923.Peer-Reviewed Original ResearchInsulin resistanceMIF secretionPref-1 expressionPref-1Fat-induced insulin resistancePlasma MIF levelsNon-inflammatory mechanismsActivation of PAR2Palmitic acid dietHigh fat-induced insulin resistanceWhite adipose tissueSubsequent insulin resistanceMIF levelsPAR2 expressionM2 macrophagesAcid dietAdipose tissueAMPK-dependent mannerEndothelial cellsSecretionIntegrin β1CellsExpressionHigh levelsInflammation
2010
P81 MIF-DEFICIENCY REDUCES CHRONIC INFLAMMATION IN ADIPOSE TISSUE AND IMPAIRS INSULIN RESISTANCE AND ASSOCIATED ATHEROSCLEROSIS IN A MODEL OF COMBINED DISEASE
Kleemann R, Verschuren L, Wielinga P, Voshol P, van Erk M, Fingerle-Rowson G, van Dijk K, Ouwens M, Bernhagen J, Bucala R, Kooistra T. P81 MIF-DEFICIENCY REDUCES CHRONIC INFLAMMATION IN ADIPOSE TISSUE AND IMPAIRS INSULIN RESISTANCE AND ASSOCIATED ATHEROSCLEROSIS IN A MODEL OF COMBINED DISEASE. Atherosclerosis Plus 2010, 11: 33. DOI: 10.1016/s1567-5688(10)70148-3.Peer-Reviewed Original Research
2002
Plasma concentrations of macrophage migration inhibitory factor are elevated in Pima Indians compared to Caucasians and are associated with insulin resistance
Vozarova B, Metz C, Stefan N, Hanson R, Lindsay R, Bucala R, Bogardus C, Tataranni P. Plasma concentrations of macrophage migration inhibitory factor are elevated in Pima Indians compared to Caucasians and are associated with insulin resistance. Diabetologia 2002, 45: 1739-1741. PMID: 12552367, DOI: 10.1007/s00125-002-0896-4.Peer-Reviewed Original Research
1999
A role for the endocrine and pro‐inflammatory mediator MIF in the control of insulin secretion during stress
Waeber G, Calandra T, Bonny C, Bucala R. A role for the endocrine and pro‐inflammatory mediator MIF in the control of insulin secretion during stress. Diabetes/Metabolism Research And Reviews 1999, 15: 47-54. PMID: 10398546, DOI: 10.1002/(sici)1520-7560(199901/02)15:1<47::aid-dmrr9>3.0.co;2-j.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorInsulin secretionMediator macrophage migration inhibitory factorSystemic inflammatory processSystemic inflammatory responseMigration inhibitory factorAnterior pituitary glandMIF levelsAdrenal axisInsulin resistanceGlucocorticoid effectsImmune cellsInflammatory processInflammatory responseInflammatory systemPeripheral tissuesGlucose homeostasisInsulin releaseHost immunityUtilization of glucosePituitary glandInhibitory factorAutocrine factorSystemic responseDisease states