2023
Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammation
Pekayvaz K, Gold C, Hoseinpour P, Engel A, Martinez-Navarro A, Eivers L, Coletti R, Joppich M, Dionísio F, Kaiser R, Tomas L, Janjic A, Knott M, Mehari F, Polewka V, Kirschner M, Boda A, Nicolai L, Schulz H, Titova A, Kilani B, Lorenz M, Fingerle-Rowson G, Bucala R, Enard W, Zimmer R, Weber C, Libby P, Schulz C, Massberg S, Stark K. Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammation. Immunity 2023, 56: 2325-2341.e15. PMID: 37652021, PMCID: PMC10588993, DOI: 10.1016/j.immuni.2023.08.002.Peer-Reviewed Original ResearchChronic inflammationVascular macrophagesPersistent tissue injuryChronic inflammatory diseaseSmooth muscle cellsMacrophage nicheInflammation contributesChemokine CCL2Inflammatory diseasesPlaque areaTissue injuryVascular bedPlaque necrosisMacrophage phenotypeAdvanced stageHomeostatic functionsNecrotic coreMuscle cellsInflammationAtherosclerosisMacrophagesMural cellsIntravital imagingProtective nicheNecrotic cells
2001
Neuroendocrine properties of macrophage migration inhibitory factor (MIF)
Fingerle‐Rowson G, Bucala R. Neuroendocrine properties of macrophage migration inhibitory factor (MIF). Immunology And Cell Biology 2001, 79: 368-375. PMID: 11488984, DOI: 10.1046/j.1440-1711.2001.01024.x.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorMigration inhibitory factorInhibitory factorCytokine macrophage migration inhibitory factorPro-inflammatory actionsMIF expressionSeptic shockNeuroendocrine mediatorsInflammatory diseasesPathogenic roleEndocrine circuitsNeuroendocrine propertiesImmune systemEndocrine tissuesImmune tissuesNeuroendocrine mechanismsDiseaseTissueArthritisNeuroendocrineFactors
2000
Regulation of macrophage migration inhibitory factor by endogenous glucocorticoids in rat adjuvant‐induced arthritis
Leech M, Metz C, Bucala R, MorAnd E. Regulation of macrophage migration inhibitory factor by endogenous glucocorticoids in rat adjuvant‐induced arthritis. Arthritis & Rheumatism 2000, 43: 827-833. PMID: 10765927, DOI: 10.1002/1529-0131(200004)43:4<827::aid-anr13>3.0.co;2-k.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorEnzyme-linked immunosorbent assaySerum MIF levelsMigration inhibitory factorMIF levelsEndogenous glucocorticoidsADX ratsSham operationRegulation of MIFInhibitory factorIsotype-matched control antibodyTumor necrosis factor alphaAdjuvant arthritis inductionClinical disease parametersReversal of diseaseNecrosis factor alphaSites of inflammationArthritis inductionArthritis developmentMIF productionMIF releaseControl antibodyInflammatory diseasesSignificant exacerbationSupernatant levels
1997
Macrophage migration inhibitory factor: a regulator of glucocorticoid activity with a critical role in inflammatory disease
Donnelly S, Bucala R. Macrophage migration inhibitory factor: a regulator of glucocorticoid activity with a critical role in inflammatory disease. Trends In Molecular Medicine 1997, 3: 502-507. PMID: 9430786, DOI: 10.1016/s1357-4310(97)01133-7.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorAcute respiratory distress syndromeRelease of MIFFunction of MIFEfficacy of glucocorticoidsRespiratory distress syndromeAnti-inflammatory effectsMigration inhibitory factorEffects of glucocorticoidsAnterior pituitary glandARDS pathogenesisDistress syndromeGlucocorticoid activityInflammatory diseasesT cellsFirst cytokineInflammatory sitesPituitary glandInhibitory factorGlucocorticoidsCritical rolePhysiological responsesCytokinesPathogenesisSyndromeRegulatory role for macrophage migration inhibitory factor in acute respiratory distress syndrome
Donnelly S, Haslett C, Reid P, Grant I, Wallace W, Metz C, Bruce L, Bucala R. Regulatory role for macrophage migration inhibitory factor in acute respiratory distress syndrome. Nature Medicine 1997, 3: 320-323. PMID: 9055860, DOI: 10.1038/nm0397-320.Peer-Reviewed Original ResearchConceptsAcute respiratory distress syndromeMigration inhibitory factorRespiratory distress syndromeDistress syndromeSignificant pro-inflammatory effectsInhibitory factorMacrophage migration inhibitory factorPro-inflammatory cytokine secretionPulmonary inflammatory responseAnti-inflammatory actionAnti-inflammatory effectsPro-inflammatory effectsIL-8 secretionConcentration-related fashionNovel therapeutic approachesInflammatory diseasesCytokine secretionInflammatory responseTherapeutic approachesAlveolar airspaceAlveolar cellsPatientsGlucocorticoidsSyndromeSecretion