2005
Glucose-mediated DNA Damage and Mutations: In Vitro and In Vivo
Lee A, Cerami A, Bucala R. Glucose-mediated DNA Damage and Mutations: In Vitro and In Vivo. 2005, 249-253. DOI: 10.1533/9781845698393.4.249.Peer-Reviewed Original ResearchEukaryotic model systemsMammalian systemsTransgenic embryosTransgenic miceSignificant genetic alterationsDNA mutationsDNA damageBiological integrityGenetic alterationsMaternal environmentMutation frequencyModel systemNucleic acidsMutationsVitroVivoFunctional activityLacI.Nonenzymatic glycosylationEmbryosGlycosylationLacI mutation frequencyDNAComparative analysisMiceAdvanced Glycosylation of LDL: Role in Oxidative Modification and Diabetic Complications
Bucala R, Makita Z, Cerami A, Vlassara H, Koschinsky T. Advanced Glycosylation of LDL: Role in Oxidative Modification and Diabetic Complications. 2005, 286-291. DOI: 10.1533/9781845698393.4.286.Peer-Reviewed Original ResearchTransition metal ionsAmine-containing phospholipidsRedox reactionsMetal ionsFree metalFacile mechanismOxidative modificationOxidationLipid oxidationApoprotein componentsMoietyGlycosylationAcid oxidationIonsAbsorbanceReactionModificationMetalsAGE moietiesFluorescencePhospholipidsPropertiesAdvanced glycosylationImmunochemical propertiesFormation
1998
Contribution of advanced glycosylation to the amyloidogenicity of islet amyloid polypeptide
Kapurniotu A, Bernhagen J, Greenfield N, Al‐Abed Y, Teichberg S, Frank R, Voelter W, Bucala R. Contribution of advanced glycosylation to the amyloidogenicity of islet amyloid polypeptide. The FEBS Journal 1998, 251: 208-216. PMID: 9492286, DOI: 10.1046/j.1432-1327.1998.2510208.x.Peer-Reviewed Original ResearchConceptsAmyloid formationIslet amyloid polypeptidePre-formed aggregatesAdvanced glycosylation end productsIAPP amyloid formationAlzheimer's disease amyloid peptideCircular dichroism spectropolarimetryNucleation-dependent polymerization mechanismBeta-sheet conformationIAPP aggregationBiophysical techniquesIAPP aggregatesHigh molecular massFormation of amyloidAmyloid structuresGreen-gold birefringenceProtein amino groupsCharacteristic fibrillar structureIslet amyloid formationSeedsFibrillar amyloid structuresGlycosylationPolymerization mechanismNon-enzymatic additionPeptide aggregation
1992
Advanced Glycosylation: Chemistry, Biology, and Implications for Diabetes and Aging
Bucala R, Cerami A. Advanced Glycosylation: Chemistry, Biology, and Implications for Diabetes and Aging. Advances In Pharmacology 1992, 23: 1-34. PMID: 1540533, DOI: 10.1016/s1054-3589(08)60961-8.Peer-Reviewed Original ResearchConceptsBiological processesGlycosylation processGlycosylation mechanismsBiochemical basisRelated pathwaysAge-related processesBiologyPathological processesGlycosylation productsDiverse effectsStructural elucidationAdvanced glycosylation productsCell-mediated processGlycosylationInsightsPathwayBiochemistryElucidationMaillard reactionAccumulationVivoLarge partMultiorgan pathology