1997
Regulatory role for macrophage migration inhibitory factor in acute respiratory distress syndrome
Donnelly S, Haslett C, Reid P, Grant I, Wallace W, Metz C, Bruce L, Bucala R. Regulatory role for macrophage migration inhibitory factor in acute respiratory distress syndrome. Nature Medicine 1997, 3: 320-323. PMID: 9055860, DOI: 10.1038/nm0397-320.Peer-Reviewed Original ResearchConceptsAcute respiratory distress syndromeMigration inhibitory factorRespiratory distress syndromeDistress syndromeSignificant pro-inflammatory effectsInhibitory factorMacrophage migration inhibitory factorPro-inflammatory cytokine secretionPulmonary inflammatory responseAnti-inflammatory actionAnti-inflammatory effectsPro-inflammatory effectsIL-8 secretionConcentration-related fashionNovel therapeutic approachesInflammatory diseasesCytokine secretionInflammatory responseTherapeutic approachesAlveolar airspaceAlveolar cellsPatientsGlucocorticoidsSyndromeSecretion
1995
MIF as a glucocorticoid-induced modulator of cytokine production
Calandra T, Bernhagen J, Metz C, Spiegel L, Bacher M, Donnelly T, Cerami A, Bucala R. MIF as a glucocorticoid-induced modulator of cytokine production. Nature 1995, 377: 68-71. PMID: 7659164, DOI: 10.1038/377068a0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternCell LineCytokinesDexamethasoneEnzyme-Linked Immunosorbent AssayFemaleGlucocorticoidsHumansHydrocortisoneImmunityInflammationLipopolysaccharidesMacrophage ActivationMacrophage Migration-Inhibitory FactorsMacrophagesMiceMice, Inbred BALB CRatsRats, Sprague-DawleyRecombinant ProteinsShock, SepticT-LymphocytesConceptsMacrophage migration inhibitory factorCounter-regulatory systemsMigration inhibitory factorProtein macrophage migration inhibitory factorGlucocorticoid protectionLethal endotoxaemiaMIF productionCytokine productionCytokine secretionMacrophage cytokinesEndogenous mediatorsImmunosuppressive propertiesImmune responseGlucocorticoid hormonesInhibitory factorHormonal systemsCritical mediatorUnexpected findingMediatorsVital functionsEndotoxaemiaCytokinesGlucocorticoidsMonocytesPituitary