2024
MIF-Modulated Spinal Proteins Associated with Persistent Bladder Pain: A Proteomics Study
Ye S, Agalave N, Ma F, Mahmood D, Al-Grety A, Khoonsari P, Leng L, Svensson C, Bucala R, Kultima K, Vera P. MIF-Modulated Spinal Proteins Associated with Persistent Bladder Pain: A Proteomics Study. International Journal Of Molecular Sciences 2024, 25: 4484. PMID: 38674069, PMCID: PMC11050327, DOI: 10.3390/ijms25084484.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, Differentiation, B-LymphocyteCystitis, InterstitialDisease Models, AnimalFemaleHistocompatibility Antigens Class IIHyperalgesiaIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMiceProteomicsReceptors, CXCR4Receptors, ImmunologicSpinal CordUrinary BladderConceptsMacrophage migration inhibitory factorProtease activated receptor 4C-X-C chemokine receptor type 4Bladder hyperalgesiaBladder painSpinal proteinsMIF receptor CD74MIF antagonismL6-S1 spinal segmentsSpinal mechanismsInterstitial cystitis/bladder pain syndromeMIF receptorSeparate groups of miceChemokine receptor type 4Associated with reliefGroups of miceC-X-CMigration inhibitory factorChanges compared to controlsBladder inflammationPain syndromeFemale miceNo significant changesSham i.Receptor 4
2023
Urothelial Oxidative Stress and ERK Activation Mediate HMGB1-Induced Bladder Pain
Ye S, Mahmood D, Ma F, Leng L, Bucala R, Vera P. Urothelial Oxidative Stress and ERK Activation Mediate HMGB1-Induced Bladder Pain. Cells 2023, 12: 1440. PMID: 37408274, PMCID: PMC10217556, DOI: 10.3390/cells12101440.Peer-Reviewed Original ResearchConceptsHigh mobility group box 1Macrophage migration inhibitory factorBladder painOxidative stressDisulfide HMGB1Mobility group box 1MIF-deficient miceNovel potential therapeutic strategyMigration inhibitory factorGroup box 1Potential therapeutic strategyOxidative stress productionN-acetylcysteine amideERK activationIntravesical treatmentMicturition volumeMicturition parametersReceptor 4Mechanical thresholdPainTherapeutic strategiesBox 1Bladder tissueInhibitory factorWestern blot
2022
Bladder Oxidative Stress and HMGB1 Release Contribute to PAR4-Mediated Bladder Pain in Mice
Ye S, Ma F, Mahmood DFD, Meyer-Siegler KL, Leng L, Bucala R, Vera PL. Bladder Oxidative Stress and HMGB1 Release Contribute to PAR4-Mediated Bladder Pain in Mice. Frontiers In Systems Neuroscience 2022, 16: 882493. PMID: 35645739, PMCID: PMC9135998, DOI: 10.3389/fnsys.2022.882493.Peer-Reviewed Original ResearchHigh mobility group box 1Macrophage migration inhibitory factorBladder painIntravesical fluidOxidative stressLevels of HMGB1Mobility group box 1Bladder oxidative stressFemale C57BL/6 miceMigration inhibitory factorGroup box 1Possible therapeutic strategiesN-acetylcysteine amideBladder edemaMIF antagonismMIF deficiencyHMGB1 concentrationsMicturition frequencyMicturition volumeMIF releaseHMGB1 levelsC57BL/6 miceMicturition parametersHistological signsHistological evidenceMP07-05 BLADDER OXIDATIVE STRESS AND ERK SIGNALING CONTRIBUTE TO BLADDER PAIN MEDIATED BY MACROPHAGE MIGRATION INHIBITORY FACTOR AND HIGH MOBILITY GROUP BOX 1
Ye S, Ma F, Mahmood D, Meyer-Siegler K, Leng L, Bucala R, Vera P. MP07-05 BLADDER OXIDATIVE STRESS AND ERK SIGNALING CONTRIBUTE TO BLADDER PAIN MEDIATED BY MACROPHAGE MIGRATION INHIBITORY FACTOR AND HIGH MOBILITY GROUP BOX 1. Journal Of Urology 2022, 207: e116. DOI: 10.1097/ju.0000000000002529.05.Peer-Reviewed Original Research
2021
Intravesical CD74 and CXCR4, macrophage migration inhibitory factor (MIF) receptors, mediate bladder pain
Ye S, Ma F, Mahmood DFD, Meyer-Siegler KL, Menard RE, Hunt DE, Leng L, Bucala R, Vera PL. Intravesical CD74 and CXCR4, macrophage migration inhibitory factor (MIF) receptors, mediate bladder pain. PLOS ONE 2021, 16: e0255975. PMID: 34424927, PMCID: PMC8382170, DOI: 10.1371/journal.pone.0255975.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorHigh mobility group box 1Bladder painMIF receptorHMGB1 releaseBladder hyperalgesiaMobility group box 1MIF receptor CD74Migration inhibitory factorGroup box 1Primary urothelial cellsInhibitory factor receptorWarrants further investigationCD74 receptorReceptor CD74Micturition parametersReceptor antagonistReceptor 4Box 1PainInhibitory factorHyperalgesiaCD74Urothelial cellsNovel target
2020
MP28-13 ACTIVATION OF INTRAVESICAL MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) RECEPTORS MEDIATES BLADDER PAIN
Ye S, Ma F, Meyer-Siegler K, Leng L, Bucala R, Vera* P. MP28-13 ACTIVATION OF INTRAVESICAL MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) RECEPTORS MEDIATES BLADDER PAIN. Journal Of Urology 2020, 203 DOI: 10.1097/ju.0000000000000867.013.Peer-Reviewed Original ResearchBladder painPain