2021
Effect of Hydroxychloroquine on QTc in Patients Diagnosed with COVID-19: A Systematic Review and Meta-Analysis
Arfaras-Melainis A, Tzoumas A, Kokkinidis D, Guerrero M, Varrias D, Xu X, Cerna L, Avendano R, Kemal C, Palaiodimos L, Faillace R. Effect of Hydroxychloroquine on QTc in Patients Diagnosed with COVID-19: A Systematic Review and Meta-Analysis. Journal Of Cardiovascular Development And Disease 2021, 8: 55. PMID: 34068104, PMCID: PMC8152730, DOI: 10.3390/jcdd8050055.Peer-Reviewed Original ResearchSARS-CoV-2 infectionUse of hydroxychloroquineAddition of azithromycinEffect of hydroxychloroquineSystematic reviewQTc prolongationQTc intervalManagement of patientsNumber of patientsCOVID-19Random-effects modelMedRxiv databasesCombination therapyConcomitant useInclusion criteriaHydroxychloroquinePatientsI-squarePrespecified endpointsAzithromycinQTcMeta-AnalysisInfectionSignificant increaseΔQTc
2018
Bivalirudin versus heparin in patients undergoing percutaneous peripheral interventions: A systematic review and meta-analysis
Olmedo W, Villablanca P, Sanina C, Walker J, Weinreich M, Brevik J, Avendano R, Bravo C, Romero J, Ramakrishna H, Babaev A, Attubato M, Hernandez-Suarez D, Cox-Alomar P, Pyo R, Krishnan P, Wiley J. Bivalirudin versus heparin in patients undergoing percutaneous peripheral interventions: A systematic review and meta-analysis. Vascular 2018, 27: 78-89. PMID: 30501582, DOI: 10.1177/1708538118807522.Peer-Reviewed Original ResearchConceptsPercutaneous peripheral interventionsAccess site complicationsPeripheral interventionsCause mortalitySite complicationsMinor bleedingSystematic reviewEfficacy of bivalirudinProcedural anticoagulant agentLarge randomized trialsSignificant differencesBivalirudin useMajor bleedingIntracranial bleedingBlood transfusionRandomized trialsMyocardial infarctionAnticoagulant agentsClinical studiesBivalirudinBleedingComplicationsPatientsHeparinMortalityCombined Endocardial-Epicardial Versus Endocardial Catheter Ablation Alone for Ventricular Tachycardia in Structural Heart Disease A Systematic Review and Meta-Analysis
Romero J, Cerrud-Rodriguez R, Di Biase L, Diaz J, Alviz I, Grupposo V, Cerna L, Avendano R, Tedrow U, Natale A, Tung R, Kumar S. Combined Endocardial-Epicardial Versus Endocardial Catheter Ablation Alone for Ventricular Tachycardia in Structural Heart Disease A Systematic Review and Meta-Analysis. JACC Clinical Electrophysiology 2018, 5: 13-24. PMID: 30678778, DOI: 10.1016/j.jacep.2018.08.010.Peer-Reviewed Original ResearchConceptsArrhythmogenic right ventricular cardiomyopathyVentricular tachycardiaNonischemic cardiomyopathyIschemic cardiomyopathyProcedural complicationsVT recurrenceEndocardial ablationVT ablationLower riskSystematic reviewLimited single-center studyEndocardial catheter ablationSingle-center studyAcute procedural complicationsA Systematic ReviewRight ventricular cardiomyopathyCause mortalityCatheter ablationEmbase databasesVentricular cardiomyopathyAblation strategyNonsignificant trendSubsequent mortalityPatientsMeta-AnalysisClinical outcomes in patients with atrial fibrillation receiving amiodarone on NOACs vs. warfarin
Avendano R, Romero J, Lupercio F, Diaz J, Quispe R, Golive A, Natale A, Garcia M, Krumerman A, Di Biase L. Clinical outcomes in patients with atrial fibrillation receiving amiodarone on NOACs vs. warfarin. Journal Of Interventional Cardiac Electrophysiology 2018, 54: 73-80. PMID: 30128801, DOI: 10.1007/s10840-018-0427-y.Peer-Reviewed Original ResearchConceptsNew oral anticoagulantsMajor bleedingAtrial fibrillationThromboembolic eventsIntracranial bleedingClinical outcomesRisk ratioStroke/thromboembolic eventsRecent retrospective trialsMantel-Haenszel methodConclusionAmong patientsTE preventionOral anticoagulantsIncreased riskRetrospective trialsResultsA totalHigh riskAmiodaroneBleedingPatientsWarfarinSystematic reviewP-glycoproteinConfidence intervalsOutcomesUninterrupted direct oral anticoagulants vs. uninterrupted vitamin K antagonists during catheter ablation of non-valvular atrial fibrillation: a systematic review and meta-analysis of randomized controlled trials
Romero J, Cerrud-Rodriguez R, Diaz J, Michaud G, Taveras J, Alviz I, Grupposo V, Cerna L, Avendano R, Kumar S, Kirchhof P, Natale A, Di Biase L. Uninterrupted direct oral anticoagulants vs. uninterrupted vitamin K antagonists during catheter ablation of non-valvular atrial fibrillation: a systematic review and meta-analysis of randomized controlled trials. EP Europace 2018, 20: 1612-1620. PMID: 29982383, DOI: 10.1093/europace/euy133.Peer-Reviewed Original ResearchConceptsNon-valvular atrial fibrillationUninterrupted direct oral anticoagulantsUninterrupted vitamin K antagonistsDirect oral anticoagulantsVitamin K antagonistsMajor bleeding eventsSilent cerebral infarctionThrombo-embolic eventsCatheter ablationBleeding eventsAtrial fibrillationMajor bleedingK antagonistsOral anticoagulantsSystematic reviewBrain magnetic resonance imagingMinor bleeding eventsFirst-line therapyParoxysmal atrial fibrillationRandom-effects modelMagnetic resonance imagingFixed-effects modelMinor bleedingCerebral infarctionLine therapyBenefit of left atrial appendage electrical isolation for persistent and long-standing persistent atrial fibrillation: a systematic review and meta-analysis
Romero J, Michaud G, Avendano R, Briceño D, Kumar S, Diaz J, Mohanty S, Trivedi C, Gianni C, Della Rocca D, Proietti R, Perrotta L, Bordignon S, Chun J, Schmidt B, Garcia M, Natale A, Di Biase L. Benefit of left atrial appendage electrical isolation for persistent and long-standing persistent atrial fibrillation: a systematic review and meta-analysis. EP Europace 2018, 20: 1268-1278. PMID: 29342299, DOI: 10.1093/europace/eux372.Peer-Reviewed Original ResearchConceptsAtrial appendage electrical isolationPersistent atrial fibrillationAtrial fibrillationIschemic strokeSystematic reviewNon-paroxysmal AF patientsStandard ablationNon-paroxysmal atrial fibrillationAcute procedural complicationsIncremental benefitAcute complication rateLong-term outcomesAntiarrhythmic medicationsArrhythmia recurrenceComplication rateAF patientsProcedural complicationsCatheter ablationAtrial arrhythmiasClinical studiesOverall freedomLAAEIPatientsLSPAFFibrillation