Isoaspartyl Post-translational Modification Triggers Autoimmune Responses to Self-proteins*
Mamula M, Gee R, Elliott J, Sette A, Southwood S, Jones P, Blier P. Isoaspartyl Post-translational Modification Triggers Autoimmune Responses to Self-proteins*. Journal Of Biological Chemistry 1999, 274: 22321-22327. PMID: 10428801, DOI: 10.1074/jbc.274.32.22321.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAspartic AcidAutoantibodiesAutoimmunityB-LymphocytesBinding, CompetitiveCytochrome c GroupHistocompatibility Antigens Class IIImmune ToleranceIsomerismLymphocyte ActivationMiceMice, Inbred MRL lprMolecular Sequence DataNuclear Magnetic Resonance, BiomolecularPeptide FragmentsProtein BindingProtein Processing, Post-TranslationalRibonucleoproteins, Small NuclearT-LymphocytesConceptsSystemic lupus erythematosusAutoimmune responseT cell autoimmune responsesHuman systemic lupus erythematosusInitiation of autoimmunityT cell compartmentT cell responsesImmunization of miceFunctioning immune systemLupus erythematosusSelf antigensAutoimmune diseasesImmunologic stimuliC-peptidePeptide autoantigensImmune systemCell responsesForeign pathogensImmunizationCytochrome c peptideMiceCell compartmentPresent studyPeptidesResponseT cell autoimmunity in Ig transgenic mice.
Shinde S, Gee R, Santulli-Marotto S, Bockenstedt L, Clarke S, Mamula M. T cell autoimmunity in Ig transgenic mice. The Journal Of Immunology 1999, 162: 7519-24. PMID: 10358207, DOI: 10.4049/jimmunol.162.12.7519.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen PresentationAutoantigensB-LymphocytesCD4-Positive T-LymphocytesFlow CytometryGenes, ImmunoglobulinHistocompatibility Antigens Class IILupus Erythematosus, SystemicMiceMice, Inbred C57BLMice, Inbred MRL lprMice, TransgenicPeptidesReceptors, Antigen, B-CellRibonucleoproteins, Small NuclearT-LymphocytesConceptsAutoreactive T cellsCD4 T cellsT cellsTransgenic miceB lymphocytesMRL-lpr/lpr miceLpr/lpr miceT cell autoimmunityAutoreactive B lymphocytesSystemic lupus erythematosusWild-type C57BL/6Wild-type miceC57BL/6 transgenic miceTransgenic B lymphocytesIg transgenic miceB cell APCCell autoimmunityLupus erythematosusLpr miceT lymphocytesMurine modelImmature phenotypeLymphocytesVivo activationMice