Sex differences in the pleiotropy of hearing difficulty with imaging-derived phenotypes: a brain-wide investigation
He J, Cabrera-Mendoza B, De Angelis F, Pathak G, Koller D, Curhan S, Curhan G, Mecca A, van Dyck C, Polimanti R. Sex differences in the pleiotropy of hearing difficulty with imaging-derived phenotypes: a brain-wide investigation. Brain 2024, 147: 3395-3408. PMID: 38454550, PMCID: PMC11449129, DOI: 10.1093/brain/awae077.Peer-Reviewed Original ResearchImaging-derived phenotypesHearing difficultiesBrain imaging-derived phenotypesSex-combined analysisLatent causal variable analysesMendelian randomization approachGeneralized linear regression analysisLocal genetic correlation analysisMultivariate generalized linear regression analysisGenome-wide association studiesLatent causal variableGenetic correlation analysisGenetic correlationsLocal genetic correlationMendelian randomizationPeripheral auditory systemOlder adultsGWAS dataLinear regression analysisHealth burdenGenomic regionsAssociation studiesPleiotropic regionsSex differencesTranscriptome regulationUnraveling COVID-19 relationship with anxiety disorders and symptoms using genome-wide data
Asgel Z, Kouakou M, Koller D, Pathak G, Cabrera-Mendoza B, Polimanti R. Unraveling COVID-19 relationship with anxiety disorders and symptoms using genome-wide data. Journal Of Affective Disorders 2024, 352: 333-341. PMID: 38382819, PMCID: PMC10939738, DOI: 10.1016/j.jad.2024.02.061.Peer-Reviewed Original ResearchAnxiety disordersAnxiety symptomsAnxiety outcomesPeriods of anxietyCorrelates of anxiety disordersGenome-wide dataLocal genetic correlationLatent causal variable analysesBrain morphologyAnxietyGenetic correlationsCOVID-19 positive statusGenetic causality proportionDisordersPleiotropic mechanismsMillion Veteran ProgramVeteran ProgramSymptomsCOVID-19 hospitalizationCOVID-19 Host Genetics InitiativeComorbidityMultiple lociHost Genetics InitiativeCOVID-19 outcomesPositive status