2019
The Replisome Mediates A-NHEJ Repair of Telomeres Lacking POT1-TPP1 Independently of MRN Function
Rai R, Gu P, Broton C, Kumar-Sinha C, Chen Y, Chang S. The Replisome Mediates A-NHEJ Repair of Telomeres Lacking POT1-TPP1 Independently of MRN Function. Cell Reports 2019, 29: 3708-3725.e5. PMID: 31825846, PMCID: PMC7001145, DOI: 10.1016/j.celrep.2019.11.012.Peer-Reviewed Original ResearchMeSH KeywordsAcid Anhydride HydrolasesAdaptor Proteins, Signal TransducingAminopeptidasesAnimalsCell Cycle ProteinsCell Line, TumorCells, CulturedCheckpoint Kinase 1Dipeptidyl-Peptidases and Tripeptidyl-PeptidasesDNA End-Joining RepairDNA Repair EnzymesDNA-Binding ProteinsDNA-Directed DNA PolymeraseExodeoxyribonucleasesHEK293 CellsHumansMiceMRE11 Homologue ProteinMultienzyme ComplexesProliferating Cell Nuclear AntigenSerine ProteasesShelterin ComplexTelomereTelomere-Binding ProteinsTelomeric Repeat Binding Protein 2ConceptsReplication protein AReplisome complexPOT1-TPP1Dysfunctional telomeresDNA damage sensor MRE11-RAD50DNA damage checkpoint responseAlternative non-homologous endNon-homologous endMRN functionChromosome endsMre11-Rad50Checkpoint responseDNA-PKTelomeric overhangMre11 nucleaseTelomere repairEnd resectionRAD-51Repair pathwaysAtaxia telangiectasiaTelomeresC-strandDNA damageReplisomeClaspin
2008
Differential regulation of centrosome integrity by DNA damage response proteins
Rai R, Phadnis A, Haralkar S, Badwe RA, Dai H, Li K, Lin SY. Differential regulation of centrosome integrity by DNA damage response proteins. Cell Cycle 2008, 7: 2225-2233. PMID: 18635967, PMCID: PMC2557875, DOI: 10.4161/cc.7.14.6303.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAurora KinasesBreast NeoplasmsCell Cycle ProteinsCell Line, TumorCentrosomeCytokinesisCytoskeletal ProteinsDisease ProgressionDNA DamageFemaleHumansMitosisModels, BiologicalNerve Tissue ProteinsNuclear ProteinsProtein Serine-Threonine KinasesProtein TransportProto-Oncogene ProteinsSpindle ApparatusTrans-ActivatorsConceptsCentrosome integritySpindle assemblyCentrosome duplicationDNA damage response proteinsProper centrosome duplicationDamage response proteinsMitotic spindle assemblySpindle checkpoint activationTumor suppressor geneDefective mitosisChromosome missegregationCentrosomal kinaseDefective cytokinesisCheckpoint activationCentrosome maturationNovel functionResponse proteinsBRIT1MDC1Key regulatorNegative regulatorAurora ACentrosome overduplicationDifferential regulationDNA damage