2016
Innate Fear-Induced Weight Regulation in the C57BL/6J Mouse
Genné-Bacon EA, Trinko JR, DiLeone RJ. Innate Fear-Induced Weight Regulation in the C57BL/6J Mouse. Frontiers In Behavioral Neuroscience 2016, 10: 132. PMID: 27458352, PMCID: PMC4930939, DOI: 10.3389/fnbeh.2016.00132.Peer-Reviewed Original ResearchHigh-fat dietWeight regulationBody weightBrown adipose thermogenesisDifferential weight gainWeek old miceLong-term neural plasticityDorsomedial hypothalamusFat dietAdipose thermogenesisC57BL/6J miceDiet groupFood intakeBA groupNeural plasticityChronic stressWeight gainAversive doseMiceΔFosB proteinButyric acidMT exposureActivity levelsUnderlying mechanismMetabolic adaptation
2012
Gene Profiling Reveals a Role for Stress Hormones in the Molecular and Behavioral Response to Food Restriction
Guarnieri DJ, Brayton CE, Richards SM, Maldonado-Aviles J, Trinko JR, Nelson J, Taylor JR, Gourley SL, DiLeone RJ. Gene Profiling Reveals a Role for Stress Hormones in the Molecular and Behavioral Response to Food Restriction. Biological Psychiatry 2012, 71: 358-365. PMID: 21855858, PMCID: PMC3237832, DOI: 10.1016/j.biopsych.2011.06.028.Peer-Reviewed Original ResearchConceptsFood restrictionGene expressionExpression changesStress-responsive genesBrain regionsWhole-genome microarraysPersistent expression changesGene expression profilesMale C57BL/6J miceAdministration of corticosteroneVentral tegmental areaIntact adrenal glandsEnzyme-linked immunosorbentMedial prefrontal cortexQuantitative polymerase chain reactionResponsive genesNonrestricted animalsDaily injectionsAdrenal glandC57BL/6J miceExpression profilesPlasma levelsPolymerase chain reactionCORT treatmentTegmental area