Featured Publications
Brain responses to nutrients are severely impaired and not reversed by weight loss in humans with obesity: a randomized crossover study
van Galen K, Schrantee A, ter Horst K, la Fleur S, Booij J, Constable R, Schwartz G, DiLeone R, Serlie M. Brain responses to nutrients are severely impaired and not reversed by weight loss in humans with obesity: a randomized crossover study. Nature Metabolism 2023, 5: 1059-1072. PMID: 37308722, DOI: 10.1038/s42255-023-00816-9.Peer-Reviewed Original ResearchConceptsDiet-induced weight lossCerebral neuronal activityStriatal dopamine releaseWeight lossCrossover studyDopamine releaseNeuronal activityIntragastric glucoseNeuronal responsesSuccessful weight lossHealthy body weightSignificant weight lossBrain responsesPathological feeding behaviorsWeight regainHunger scoresLipid infusionLean participantsCaloric intakePlasma hormonesObesityBody weightInfusionNutrient signalsHigh rate
2016
Innate Fear-Induced Weight Regulation in the C57BL/6J Mouse
Genné-Bacon EA, Trinko JR, DiLeone RJ. Innate Fear-Induced Weight Regulation in the C57BL/6J Mouse. Frontiers In Behavioral Neuroscience 2016, 10: 132. PMID: 27458352, PMCID: PMC4930939, DOI: 10.3389/fnbeh.2016.00132.Peer-Reviewed Original ResearchHigh-fat dietWeight regulationBody weightBrown adipose thermogenesisDifferential weight gainWeek old miceLong-term neural plasticityDorsomedial hypothalamusFat dietAdipose thermogenesisC57BL/6J miceDiet groupFood intakeBA groupNeural plasticityChronic stressWeight gainAversive doseMiceΔFosB proteinButyric acidMT exposureActivity levelsUnderlying mechanismMetabolic adaptation