2024
Neural Correlates of Stress and Alcohol Cue-Induced Alcohol Craving and of Future Heavy Drinking: Evidence of Sex Differences
Radoman M, Fogelman N, Lacadie C, Seo D, Sinha R. Neural Correlates of Stress and Alcohol Cue-Induced Alcohol Craving and of Future Heavy Drinking: Evidence of Sex Differences. American Journal Of Psychiatry 2024, 181: 412-422. PMID: 38706332, PMCID: PMC11117176, DOI: 10.1176/appi.ajp.20230849.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcohol DrinkingAlcoholismBrainCravingCuesFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedProspective StudiesSex CharacteristicsSex FactorsStress, PsychologicalConceptsAlcohol use disorderPercentage of heavy drinking daysNeural correlates of stressCue-induced cravingHeavy drinking daysAlcohol cravingSex differencesCorrelates of stressDrinking daysAlcohol cue-induced cravingCue-induced alcohol cravingBed nucleus of the stria terminalisSubgenual anterior cingulate cortexAssessment of alcohol cravingHeavy drinkingAlcohol cue reactivityAssociated with poor treatment outcomesCue-induced responsesNeutral cue exposureAssociated with hypoactivationTreatment-seeking adultsHeavy drinking outcomesEvidence of sex differencesVoxel-based regression analysisAnterior cingulate cortex
2023
Hippocampal Mechanisms Support Cortisol-Induced Memory Enhancements
Sherman B, Harris B, Turk-Browne N, Sinha R, Goldfarb E. Hippocampal Mechanisms Support Cortisol-Induced Memory Enhancements. Journal Of Neuroscience 2023, 43: 7198-7212. PMID: 37813570, PMCID: PMC10601369, DOI: 10.1523/jneurosci.0916-23.2023.Peer-Reviewed Original ResearchMeSH KeywordsBrainEmotionsFemaleHippocampusHumansHydrocortisoneMagnetic Resonance ImagingMaleMemory, EpisodicConceptsFunctional magnetic resonance imagingMemory enhancementEpisodic memoryAssociative memoryEpisodic memory encodingBrain regionsHigh-resolution functional magnetic resonance imagingHuman hippocampusHigh-resolution fMRIStress-related hormone cortisolHormone cortisolMemory benefitsEmotional memoryMemory encodingEmotional eventsEmotional associationsHippocampal representationsHippocampal signaturesFunctional neuroimagingHippocampal mechanismsStressful eventsFunctional connectivityHippocampal functionMemory formationSalient informationBrain volumes in alcohol use disorder: Do females and males differ? A whole‐brain magnetic resonance imaging mega‐analysis
Maggioni E, Rossetti M, Allen N, Batalla A, Bellani M, Chye Y, Cousijn J, Goudriaan A, Hester R, Hutchison K, Li C, Martin‐Santos R, Momenan R, Sinha R, Schmaal L, Solowij N, Suo C, van Holst R, Veltman D, Yücel M, Thompson P, Conrod P, Mackey S, Garavan H, Brambilla P, Lorenzetti V. Brain volumes in alcohol use disorder: Do females and males differ? A whole‐brain magnetic resonance imaging mega‐analysis. Human Brain Mapping 2023, 44: 4652-4666. PMID: 37436103, PMCID: PMC10400785, DOI: 10.1002/hbm.26404.Peer-Reviewed Original ResearchTransdiagnostic Connectome-Based Prediction of Craving
Garrison K, Sinha R, Potenza M, Gao S, Liang Q, Lacadie C, Scheinost D. Transdiagnostic Connectome-Based Prediction of Craving. American Journal Of Psychiatry 2023, 180: 445-453. PMID: 36987598, DOI: 10.1176/appi.ajp.21121207.Peer-Reviewed Original ResearchMeSH KeywordsBehavior, AddictiveBrainConnectomeCravingCuesHumansMagnetic Resonance ImagingSubstance-Related DisordersConceptsConnectome-based predictive modelingImagery conditionFunctional connectomeSelf-reported cravingStudy of motivationDefault mode networkFunctional connectivity dataIndependent samplesKey phenomenological featuresNeural signaturesTransdiagnostic sampleTransdiagnostic perspectiveMode networkMotivated behaviorCentral constructAddictive disordersHuman behaviorConnectivity dataPhenomenological featuresStrongest predictorCravingTaskSubstance use-related disordersConnectomeIndividualsSex differences in neural responses to stress and drug cues predicts future drug use in individuals with substance use disorder
Smith K, Lacadie C, Milivojevic V, Fogelman N, Sinha R. Sex differences in neural responses to stress and drug cues predicts future drug use in individuals with substance use disorder. Drug And Alcohol Dependence 2023, 244: 109794. PMID: 36758371, PMCID: PMC10024802, DOI: 10.1016/j.drugalcdep.2023.109794.Peer-Reviewed Original ResearchMeSH KeywordsBrainCuesFemaleHumansMagnetic Resonance ImagingMalePrefrontal CortexSex CharacteristicsSubstance-Related DisordersConceptsSubstance use disordersDrug cuesFuture drug useDrug use daysCue exposureNeural responsesUse daysSex differencesVentromedial prefrontal cortexScript-driven imageryDrug cue exposureNeutral cue exposureWhole-brain analysisWhole-brain correlationUse disordersDrug use outcomesCue-induced anxietyBrain responsesHeart rateFMRI scansPrefrontal cortexDrug cravingDrug useBrain analysisBrain correlations
2022
Mental imagery content is associated with disease severity and specific brain functional connectivity changes in patients with Parkinson’s disease
Cherry J, Kamel S, Elfil M, Aravala S, Bayoumi A, Patel A, Sinha R, Tinaz S. Mental imagery content is associated with disease severity and specific brain functional connectivity changes in patients with Parkinson’s disease. Brain Imaging And Behavior 2022, 17: 161-171. PMID: 36434490, PMCID: PMC10050121, DOI: 10.1007/s11682-022-00749-z.Peer-Reviewed Original ResearchMeSH KeywordsBrainBrain MappingHumansImaginationMagnetic Resonance ImagingParkinson DiseasePatient AcuityConceptsImagery trainingFunctional connectivity changesMild Parkinson's diseaseVisual imagery trainingMental imagery trainingComplex cognitive processesConnectivity changesMotor imagery trainingBrain functional connectivity changesFunctional connectivity characteristicsExecutive processesMental imageryCognitive processesPerceptual experienceNeural correlatesBrain mechanismsImagery practiceImagery contentSensorimotor processesNeuropsychiatric patient populationsMotor functionMotor actsMotor enhancementBrain areasParkinson's diseaseCortical profiles of numerous psychiatric disorders and normal development share a common pattern
Cao Z, Cupertino R, Ottino-Gonzalez J, Murphy A, Pancholi D, Juliano A, Chaarani B, Albaugh M, Yuan D, Schwab N, Stafford J, Goudriaan A, Hutchison K, Li C, Luijten M, Groefsema M, Momenan R, Schmaal L, Sinha R, van Holst R, Veltman D, Wiers R, Porjesz B, Lett T, Banaschewski T, Bokde A, Desrivières S, Flor H, Grigis A, Gowland P, Heinz A, Brühl R, Martinot J, Martinot M, Artiges E, Nees F, Orfanos D, Paus T, Poustka L, Hohmann S, Millenet S, Fröhner J, Robinson L, Smolka M, Walter H, Winterer J, Schumann G, Whelan R, Bhatt R, Zhu A, Conrod P, Jahanshad N, Thompson P, Mackey S, Garavan H. Cortical profiles of numerous psychiatric disorders and normal development share a common pattern. Molecular Psychiatry 2022, 28: 698-709. PMID: 36380235, DOI: 10.1038/s41380-022-01855-6.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgingBrainCerebral CortexChildHumansMagnetic Resonance ImagingMental DisordersPotassium Channels, Voltage-GatedConceptsCortical thicknessPsychiatric disordersNumerous psychiatric disordersNeurological disordersDesikan-Killiany atlasLower cortical thicknessNormative maturationAllen Human Brain AtlasHealthy adult participantsCortical maturationExpression of PC1Cortical changesEmergence of psychopathologyBrain maturationPsychiatric diseasesMultiple gene ontology categoriesHuman Brain AtlasCortical profilesPubertal transitionCT differencesDisordersLate childhoodABCD studyAdult participantsNeurobiological basisNeural correlates linking trauma and physical symptoms
Choi J, Martins J, Hwang S, Sinha R, Seo D. Neural correlates linking trauma and physical symptoms. Psychiatry Research Neuroimaging 2022, 327: 111560. PMID: 36327865, PMCID: PMC9757618, DOI: 10.1016/j.pscychresns.2022.111560.Peer-Reviewed Original ResearchConceptsPhysical symptomsFunctional magnetic resonance imagingTrauma patientsLateral prefrontal cortexPrefrontal cortexPhysical symptom frequencyPain-related disordersMagnetic resonance imagingNeural correlatesPhysical health symptomsChronic painHealthy controlsTrauma groupSymptom frequencyDorsal striatumGreater physical symptomsSensorimotor areasCurrent studyHippocampal responsesVentromedial prefrontal cortexHealth symptomsHippocampal functionResonance imagingSymptomsUnderlying neurological mechanisms
2020
Reproducibility in the absence of selective reporting: An illustration from large‐scale brain asymmetry research
Kong X, Kong X, Mathias S, Guadalupe T, Abé C, Agartz I, Akudjedu T, Aleman A, Alhusaini S, Allen N, Ames D, Andreassen O, Vasquez A, Armstrong N, Asherson P, Bergo F, Bastin M, Batalla A, Bauer J, Baune B, Baur‐Streubel R, Biederman J, Blaine S, Boedhoe P, Bøen E, Bose A, Bralten J, Brandeis D, Brem S, Brodaty H, Yüksel D, Brooks S, Buitelaar J, Bürger C, Bülow R, Calhoun V, Calvo A, Canales‐Rodríguez E, Cannon D, Caparelli E, Castellanos F, Cendes F, Chaim‐Avancini T, Chantiluke K, Chen Q, Chen X, Cheng Y, Christakou A, Clark V, Coghill D, Connolly C, Conzelmann A, Córdova‐Palomera A, Cousijn J, Crow T, Cubillo A, Dannlowski U, de Bruttopilo S, de Zeeuw P, Deary I, Demeter D, Di Martino A, Dickie E, Dietsche B, Doan N, Doherty C, Doyle A, Durston S, Earl E, Ehrlich S, Ekman C, Elvsåshagen T, Epstein J, Fair D, Faraone S, Fernández G, Flint C, Filho G, Förster K, Fouche J, Foxe J, Frodl T, Fuentes‐Claramonte P, Fullerton J, Garavan H, do Santos Garcia D, Gotlib I, Goudriaan A, Grabe H, Groenewold N, Grotegerd D, Gruber O, Gurholt T, Haavik J, Hahn T, Hansell N, Harris M, Hartman C, del Carmen Valdés Hernández M, Heslenfeld D, Hester R, Hibar D, Ho B, Ho T, Hoekstra P, van Holst R, Hoogman M, Høvik M, Howells F, Hugdahl K, Huyser C, Ingvar M, Ishikawa A, James A, Jahanshad N, Jernigan T, Jönsson E, Kaleda V, Kelly C, Kerich M, Keshavan M, Khadka S, Kircher T, Kohls G, Konrad K, Korucuoglu O, Krämer B, Krug A, Kuntsi J, Kwon J, Lambregts‐Rommelse N, Landén M, Lázaro L, Lebedeva I, Lenroot R, Lesch K, Li Q, Lim K, Liu J, Lochner C, London E, Lorenzetti V, Luciano M, Luijten M, Lundervold A, Mackey S, MacMaster F, Maingault S, Malpas C, Malt U, Mataix‐Cols D, Martin‐Santos R, Mayer A, McCarthy H, Medland S, Metha M, Mitchell P, Mueller B, Maniega S, Mazoyer B, McDonald C, McLellan Q, McMahon K, McPhilemy G, Momenan R, Morales A, Narayanaswamy J, Moreira J, Nerland S, Nestor L, Newman E, Nigg J, Nordvik J, Novotny S, Weiss E, O'Gorman R, Oosterlaan J, Oranje B, Orr C, Overs B, Paloyelis Y, Pauli P, Paulus M, Plessen K, von Polier G, Pomarol‐Clotet E, Portella M, Qiu J, Radua J, Ramos‐Quiroga J, Reddy Y, Reif A, Roberts G, Rosa P, Rubia K, Sacchet M, Sachdev P, Salvador R, Schmaal L, Schulte‐Rüther M, Schweren L, Seitz J, Serpa M, Shaw P, Shumskaya E, Silk T, Simmons A, Simulionyte E, Sinha R, Sjoerds Z, Smelror R, Soliva J, Solowij N, Souza‐Duran F, Sponheim S, Stein D, Stein E, Stevens M, Strike L, Sudre G, Sui J, Tamm L, Temmingh H, Thoma R, Tomyshev A, Tronchin G, Turner J, Uhlmann A, van Erp T, van den Heuvel O, van der Meer D, van Eijk L, Vance A, Veer I, Veltman D, Venkatasubramanian G, Vilarroya O, Vives‐Gilabert Y, Voineskos A, Völzke H, Vuletic D, Walitza S, Walter H, Walton E, Wardlaw J, Wen W, Westlye L, Whelan C, White T, Wiers R, Wright M, Wittfeld K, Yang T, Yasuda C, Yoncheva Y, Yücel M, Yun J, Zanetti M, Zhen Z, Zhu X, Ziegler G, de Zubicaray G, Zwiers M, Project K, Glahn D, Crivello F, Fisher S, Thompson P, Francks C, Farde L, Flyckt L, Engberg G, Erhardt S, Fatouros‐Bergman H, Cervenka S, Schwieler L, Piehl F, Agartz I, Collste K, Victorsson P, Malmqvist A, Hedberg M, Orhan F, Sellgren C, Francks C. Reproducibility in the absence of selective reporting: An illustration from large‐scale brain asymmetry research. Human Brain Mapping 2020, 43: 244-254. PMID: 32841457, PMCID: PMC8675427, DOI: 10.1002/hbm.25154.Peer-Reviewed Original Research
2016
Neural stress reactivity relates to smoking outcomes and differentiates between mindfulness and cognitive-behavioral treatments
Kober H, Brewer JA, Height KL, Sinha R. Neural stress reactivity relates to smoking outcomes and differentiates between mindfulness and cognitive-behavioral treatments. NeuroImage 2016, 151: 4-13. PMID: 27693614, PMCID: PMC5373945, DOI: 10.1016/j.neuroimage.2016.09.042.Peer-Reviewed Original ResearchMeSH KeywordsBrainBrain MappingCigarette SmokingCognitive Behavioral TherapyFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedMindfulnessSmoking CessationStress, PsychologicalTreatment OutcomeConceptsCognitive-behavioral treatmentFunctional magnetic resonance imagingStress reactivityMindfulness-based treatmentsAmerican Lung Association's FreedomUnderstanding of stressPsychological mechanismsMindfulness trainingNegative affectConjunction analysisMid insulaCBT groupStress provocationSmoking outcomesBrain regionsCessation treatmentEfficacy of MTCurrent studyEntire sampleDrug useSmoking cessationImportant implicationsMagnetic resonance imagingMindfulnessInsulaDynamic neural activity during stress signals resilient coping
Sinha R, Lacadie CM, Constable RT, Seo D. Dynamic neural activity during stress signals resilient coping. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 8837-8842. PMID: 27432990, PMCID: PMC4978278, DOI: 10.1073/pnas.1600965113.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexVentrolateral prefrontal cortexResilient copingNeural activationPrefrontal cortexFunctional magnetic resonance imaging studyDorsolateral prefrontal cortex regionsNeutral visual stimuliVentromedial prefrontal cortexHealthy stress responseDynamic neural activityPrefrontal cortex regionsAnterior cingulate cortexFrequency of argumentsMagnetic resonance imaging studyResonance imaging studyVmPFC activationEmotional eatingNeural processesStress processingVisual stimuliViolent stimuliBinge alcohol intakeBrain networksRight insula
2013
Cumulative Adversity Sensitizes Neural Response to Acute Stress: Association with Health Symptoms
Seo D, Tsou KA, Ansell EB, Potenza MN, Sinha R. Cumulative Adversity Sensitizes Neural Response to Acute Stress: Association with Health Symptoms. Neuropsychopharmacology 2013, 39: 670-680. PMID: 24051900, PMCID: PMC3895244, DOI: 10.1038/npp.2013.250.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdultAnxietyBrainBrain MappingFemaleHeart RateHumansImage Processing, Computer-AssistedImagery, PsychotherapyMagnetic Resonance ImagingMaleOxygenStress, PsychologicalConceptsMedial orbitofrontal cortexAdverse health symptomsStress-induced activityHealth symptomsOrbitofrontal cortexCumulative adversityAcute stressMagnetic resonance imaging resultsAdverse health outcomesNeural responsesCornell Medical IndexFunctional magnetic resonance imaging resultsHigh-Ca groupRight hippocampusRight amygdalaHealthy individualsCA groupHealth outcomesMedical IndexLateral prefrontal cortexSignificant associationSymptomsHealth consequencesPrefrontal cortexTemporal regionsDivergent neural substrates of inhibitory control in binge eating disorder relative to other manifestations of obesity
Balodis IM, Molina ND, Kober H, Worhunsky PD, White MA, Sinha R, Grilo CM, Potenza MN. Divergent neural substrates of inhibitory control in binge eating disorder relative to other manifestations of obesity. Obesity 2013, 21: 367-377. PMID: 23404820, PMCID: PMC3610836, DOI: 10.1002/oby.20068.Peer-Reviewed Original ResearchConceptsInferior frontal gyrusCognitive controlBED groupNeural correlatesStroop color-word interference taskColor-word interference taskRight inferior frontal gyrusVentromedial prefrontal cortexDivergent neural substratesFunctional magnetic resonanceInterference taskStroop performanceVmPFC activationDietary restraint scoresInhibitory processingDiminished abilityNeural substratesComparison participantsFrontal gyrusInhibitory controlBiobehavioral processesPrefrontal cortexDietary restraintBehavioral controlRelative hypoactivityEffects of Fructose vs Glucose on Regional Cerebral Blood Flow in Brain Regions Involved With Appetite and Reward Pathways
Page KA, Chan O, Arora J, Belfort-DeAguiar R, Dzuira J, Roehmholdt B, Cline GW, Naik S, Sinha R, Constable RT, Sherwin RS. Effects of Fructose vs Glucose on Regional Cerebral Blood Flow in Brain Regions Involved With Appetite and Reward Pathways. JAMA 2013, 309: 63-70. PMID: 23280226, PMCID: PMC4076145, DOI: 10.1001/jama.2012.116975.Peer-Reviewed Original ResearchConceptsRegional cerebral blood flowCerebral blood flowGlucose ingestionFructose ingestionFructose consumptionBlood flowGlucagon-like polypeptide-1Weight gainRegional CBF changesPrevalence of obesityHigh-fructose dietHealthy adult volunteersLower peak levelsConsumption of fructoseMagnetic resonance imaging sessionPosterior cingulate cortexWhole-brain analysisEffects of fructoseFunctional connectivity analysisSatiety hormonesSecondary outcomesDrink ingestionSystemic glucoseVoxel-level analysisInsulin resistance
2012
Cumulative Adversity and Smaller Gray Matter Volume in Medial Prefrontal, Anterior Cingulate, and Insula Regions
Ansell EB, Rando K, Tuit K, Guarnaccia J, Sinha R. Cumulative Adversity and Smaller Gray Matter Volume in Medial Prefrontal, Anterior Cingulate, and Insula Regions. Biological Psychiatry 2012, 72: 57-64. PMID: 22218286, PMCID: PMC3391585, DOI: 10.1016/j.biopsych.2011.11.022.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexGray matter volumeCumulative adversityPrefrontal cortexLife eventsSmaller gray matter volumeAnterior cingulateMatter volumeCingulate regionsRecent stressful life eventsCommunity participantsHealthy community participantsCumulative life eventsStressful life eventsStress-related psychopathologyAdverse life eventsAnterior cingulate regionsChronic stress effectsInsula regionsLife traumaKey prefrontalMedial prefrontalCommunity sampleOrbitofrontal cortexRight insula
2011
Circulating glucose levels modulate neural control of desire for high-calorie foods in humans
Page KA, Seo D, Belfort-DeAguiar R, Lacadie C, Dzuira J, Naik S, Amarnath S, Constable RT, Sherwin RS, Sinha R. Circulating glucose levels modulate neural control of desire for high-calorie foods in humans. Journal Of Clinical Investigation 2011, 121: 4161-4169. PMID: 21926468, PMCID: PMC3195474, DOI: 10.1172/jci57873.Peer-Reviewed Original ResearchConceptsHigh-calorie foodsGlucose levelsHyperinsulinemic euglycemic-hypoglycemic clampsBrain regionsFunctional MRIMedial prefrontal cortexMedial prefrontal cortex activationRisk of overeatingLevels of glucosePostprandial reductionPrefrontal cortex activationObese subjectsNonobese individualsMild hypoglycemiaWorldwide epidemicCortex activationPrefrontal cortexFood cuesFood motivationFood stimuliNeural controlObesityInhibitory controlBehavioral measuresVisual cues
2006
Imaging Response Inhibition in a Stop-Signal Task: Neural Correlates Independent of Signal Monitoring and Post-Response Processing
Li CS, Huang C, Constable RT, Sinha R. Imaging Response Inhibition in a Stop-Signal Task: Neural Correlates Independent of Signal Monitoring and Post-Response Processing. Journal Of Neuroscience 2006, 26: 186-192. PMID: 16399686, PMCID: PMC6674298, DOI: 10.1523/jneurosci.3741-05.2006.Peer-Reviewed Original ResearchConceptsStop-signal reaction timeStop-signal taskResponse inhibitionPre-potent response tendenciesReaction timeShorter stop-signal reaction timesEfficient response inhibitionFunctional magnetic resonanceLonger stop-signal reaction timesGroups of subjectsHigher cortical functionsError monitoringNeural correlatesTask demandsHabitual responsesBrain activationNeural substrataResponse tendenciesGreater activationInhibitory controlAffective functionsMotor areaBrain regionsFrontal cortexCortical function