2023
Hippocampal Mechanisms Support Cortisol-Induced Memory Enhancements
Sherman B, Harris B, Turk-Browne N, Sinha R, Goldfarb E. Hippocampal Mechanisms Support Cortisol-Induced Memory Enhancements. Journal Of Neuroscience 2023, 43: 7198-7212. PMID: 37813570, PMCID: PMC10601369, DOI: 10.1523/jneurosci.0916-23.2023.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingMemory enhancementEpisodic memoryAssociative memoryEpisodic memory encodingBrain regionsHigh-resolution functional magnetic resonance imagingHuman hippocampusHigh-resolution fMRIStress-related hormone cortisolHormone cortisolMemory benefitsEmotional memoryMemory encodingEmotional eventsEmotional associationsHippocampal representationsHippocampal signaturesFunctional neuroimagingHippocampal mechanismsStressful eventsFunctional connectivityHippocampal functionMemory formationSalient information
2016
Dynamic neural activity during stress signals resilient coping
Sinha R, Lacadie CM, Constable RT, Seo D. Dynamic neural activity during stress signals resilient coping. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 8837-8842. PMID: 27432990, PMCID: PMC4978278, DOI: 10.1073/pnas.1600965113.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexVentrolateral prefrontal cortexResilient copingNeural activationPrefrontal cortexFunctional magnetic resonance imaging studyDorsolateral prefrontal cortex regionsNeutral visual stimuliVentromedial prefrontal cortexHealthy stress responseDynamic neural activityPrefrontal cortex regionsAnterior cingulate cortexFrequency of argumentsMagnetic resonance imaging studyResonance imaging studyVmPFC activationEmotional eatingNeural processesStress processingVisual stimuliViolent stimuliBinge alcohol intakeBrain networksRight insula
2012
Cumulative Adversity and Smaller Gray Matter Volume in Medial Prefrontal, Anterior Cingulate, and Insula Regions
Ansell EB, Rando K, Tuit K, Guarnaccia J, Sinha R. Cumulative Adversity and Smaller Gray Matter Volume in Medial Prefrontal, Anterior Cingulate, and Insula Regions. Biological Psychiatry 2012, 72: 57-64. PMID: 22218286, PMCID: PMC3391585, DOI: 10.1016/j.biopsych.2011.11.022.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexGray matter volumeCumulative adversityPrefrontal cortexLife eventsSmaller gray matter volumeAnterior cingulateMatter volumeCingulate regionsRecent stressful life eventsCommunity participantsHealthy community participantsCumulative life eventsStressful life eventsStress-related psychopathologyAdverse life eventsAnterior cingulate regionsChronic stress effectsInsula regionsLife traumaKey prefrontalMedial prefrontalCommunity sampleOrbitofrontal cortexRight insula
2008
Chronic Stress, Drug Use, and Vulnerability to Addiction
Sinha R. Chronic Stress, Drug Use, and Vulnerability to Addiction. Annals Of The New York Academy Of Sciences 2008, 1141: 105-130. PMID: 18991954, PMCID: PMC2732004, DOI: 10.1196/annals.1441.030.Peer-Reviewed Original ResearchMeSH KeywordsArousalChronic DiseaseCorticotropin-Releasing HormoneDisease SusceptibilityEmotionsFemaleHumansHypothalamo-Hypophyseal SystemIllicit DrugsLimbic SystemMaleNeurotransmitter AgentsPituitary-Adrenal SystemRewardSelf MedicationStress, PhysiologicalStress, PsychologicalSubstance Withdrawal SyndromeSubstance-Related DisordersSympathetic Nervous SystemConceptsCompulsive drug seekingStress-related riskDevelopment of addictionChronic drug useEarly life stressMotivational systemsIndividual-level variablesRelapse susceptibilityRelapse vulnerabilityDrug seekingAutonomic arousalDrug useLife stressDrug-experienced animalsSpecific stressorsChild maltreatmentSubstance useMesolimbic dopamineStress exposureStress regulationAddictionChronic stressCentral noradrenergic systemNoradrenergic systemButyric acid pathway
1989
Drinking variables, affective measures and neuropsychological performance: Familial alcoholism and gender correlates
Sinha R, Parsons O, Glenn S. Drinking variables, affective measures and neuropsychological performance: Familial alcoholism and gender correlates. Alcohol 1989, 6: 77-85. PMID: 2719819, DOI: 10.1016/0741-8329(89)90077-3.Peer-Reviewed Original ResearchConceptsDrinking variablesNeuropsychological performance scoresFamily history-negative (FH-) alcoholicsNeuropsychological test performanceAlcohol intake measuresCognitive functioningNeuropsychological measuresAlcohol consumption variablesAffective measuresFemale alcoholicsNeuropsychological performanceTest performanceDepression Inventory scoresAffective symptomatologyAnxiety scoresBeck Depression Inventory scoresImpairment IndexFamilial alcoholismInventory scoresPerformance scoresIntake measuresMeasuresSignificant relationshipGender correlatesAlcohol consumption