2024
Stress and substance use disorders: risk, relapse, and treatment outcomes
Sinha R. Stress and substance use disorders: risk, relapse, and treatment outcomes. Journal Of Clinical Investigation 2024, 134: e172883. PMID: 39145454, PMCID: PMC11324296, DOI: 10.1172/jci172883.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalHumansRecurrenceRisk FactorsStress, PsychologicalSubstance-Related DisordersTreatment OutcomeConceptsSubstance use disordersDrug-related environmentPathophysiology of addictionAdaptive stress responseSUD treatment outcomesAssociated with substance misuseTreatment outcomesStress-related alterationsDrug motivationIncreased cravingNeurobiological disruptionsMaladaptive copingRepeated stressorsTreatment implicationsSubstance misuseStress pathophysiologyStress responseDrug intakeDrug withdrawalRelapse riskDrug misuseIntervention developmentDisordersCravingRelapse
2016
Neural stress reactivity relates to smoking outcomes and differentiates between mindfulness and cognitive-behavioral treatments
Kober H, Brewer JA, Height KL, Sinha R. Neural stress reactivity relates to smoking outcomes and differentiates between mindfulness and cognitive-behavioral treatments. NeuroImage 2016, 151: 4-13. PMID: 27693614, PMCID: PMC5373945, DOI: 10.1016/j.neuroimage.2016.09.042.Peer-Reviewed Original ResearchConceptsCognitive-behavioral treatmentFunctional magnetic resonance imagingStress reactivityMindfulness-based treatmentsAmerican Lung Association's FreedomUnderstanding of stressPsychological mechanismsMindfulness trainingNegative affectConjunction analysisMid insulaCBT groupStress provocationSmoking outcomesBrain regionsCessation treatmentEfficacy of MTCurrent studyEntire sampleDrug useSmoking cessationImportant implicationsMagnetic resonance imagingMindfulnessInsula
2006
Stress-Induced Cocaine Craving and Hypothalamic-Pituitary-Adrenal Responses Are Predictive of Cocaine Relapse Outcomes
Sinha R, Garcia M, Paliwal P, Kreek MJ, Rounsaville BJ. Stress-Induced Cocaine Craving and Hypothalamic-Pituitary-Adrenal Responses Are Predictive of Cocaine Relapse Outcomes. JAMA Psychiatry 2006, 63: 324-331. PMID: 16520439, DOI: 10.1001/archpsyc.63.3.324.Peer-Reviewed Original ResearchMeSH KeywordsAdrenocorticotropic HormoneAdultBehavior, AddictiveCocaine-Related DisordersCuesFemaleFollow-Up StudiesHospitalizationHumansHydrocortisoneHypothalamo-Hypophyseal SystemMaleMiddle AgedPituitary-Adrenal SystemProspective StudiesSecondary PreventionStress, PsychologicalSubstance Abuse Treatment CentersTreatment OutcomeConceptsAdrenal axis responseCocaine cravingRelapse outcomesAxis responseCocaine relapseAdrenal responseInpatient treatmentCocaine relapse outcomesCue-induced cocaine cravingStress-induced drug cravingCocaine useCocaine dependenceCox proportional hazards regressionCommunity mental health centerProportional hazards regressionMental health centersProspective study designDrug cue exposureStress-related increasesTreatment-seeking cocaine dependent individualsHazards regressionHypothalamic-PituitaryHealth centersCocaine-dependent individualsRelapse
2000
Motivation to change substance use among offenders of domestic violence
Easton C, Swan S, Sinha R. Motivation to change substance use among offenders of domestic violence. Journal Of Substance Use And Addiction Treatment 2000, 19: 1-5. PMID: 10867294, DOI: 10.1016/s0740-5472(99)00098-7.Peer-Reviewed Original Research