2017
Chapter 69 Patient Responses to Guanfacine in Cocaine Addiction
Milivojevic V, Sinha R, Fox H. Chapter 69 Patient Responses to Guanfacine in Cocaine Addiction. 2017, 679-688. DOI: 10.1016/b978-0-12-803750-8.00069-5.ChaptersAnxiety pathophysiologyDrugs of abuseNeural stress systemsDrug-seeking behaviorEmotional controlDrug seekingRecent research findingsChronic stress stateNegative consequencesCocaine addictionCocaine dependenceStress systemResearch findingsLong-term agentsCocaine useDrug useAbuseGuanfacineCravingSeekingStress sensitivityAddictionAbilityRobust adaptationOwn laboratory
2010
Cocaine
Beech R, Sinha R. Cocaine. 2010, 397-416. DOI: 10.1007/978-1-4419-0338-9_18.Peer-Reviewed Original ResearchCognitive behavior therapyBehavior therapyCocaine dependenceGeneral cognitive behavior therapyContingency managementRelapse prevention techniquesCompulsive drug seekingReward-related informationContingency management techniquesCocaine-taking behaviorConditions of challengeExecutive controlLong-term neuroadaptationsCocaine-related disordersDrug seekingCocaine useAdditional clinical attentionExtended abstinenceAnxiety disordersNeurobiological aspectsChronic cocaine useRegular cocaine useRelapse preventionPsychological symptomsNegative consequences
2006
Stress-Induced Cocaine Craving and Hypothalamic-Pituitary-Adrenal Responses Are Predictive of Cocaine Relapse Outcomes
Sinha R, Garcia M, Paliwal P, Kreek MJ, Rounsaville BJ. Stress-Induced Cocaine Craving and Hypothalamic-Pituitary-Adrenal Responses Are Predictive of Cocaine Relapse Outcomes. JAMA Psychiatry 2006, 63: 324-331. PMID: 16520439, DOI: 10.1001/archpsyc.63.3.324.Peer-Reviewed Original ResearchMeSH KeywordsAdrenocorticotropic HormoneAdultBehavior, AddictiveCocaine-Related DisordersCuesFemaleFollow-Up StudiesHospitalizationHumansHydrocortisoneHypothalamo-Hypophyseal SystemMaleMiddle AgedPituitary-Adrenal SystemProspective StudiesSecondary PreventionStress, PsychologicalSubstance Abuse Treatment CentersTreatment OutcomeConceptsAdrenal axis responseCocaine cravingRelapse outcomesAxis responseCocaine relapseAdrenal responseInpatient treatmentCocaine relapse outcomesCue-induced cocaine cravingStress-induced drug cravingCocaine useCocaine dependenceCox proportional hazards regressionCommunity mental health centerProportional hazards regressionMental health centersProspective study designDrug cue exposureStress-related increasesTreatment-seeking cocaine dependent individualsHazards regressionHypothalamic-PituitaryHealth centersCocaine-dependent individualsRelapse