2018
Unsaturated fatty acids from flaxseed oil and exercise modulate GPR120 but not GPR40 in the liver of obese mice: a new anti-inflammatory approach
Gaspar R, Veiga C, Bessi M, Dátilo M, Sant'Ana M, Rodrigues P, de Moura L, da Silva A, Santos G, Catharino R, Ropelle E, Pauli J, Cintra D. Unsaturated fatty acids from flaxseed oil and exercise modulate GPR120 but not GPR40 in the liver of obese mice: a new anti-inflammatory approach. The Journal Of Nutritional Biochemistry 2018, 66: 52-62. PMID: 30771734, DOI: 10.1016/j.jnutbio.2018.12.003.Peer-Reviewed Original ResearchConceptsHigh-fat dietPhysical exerciseObese miceNew anti-inflammatory approachesFlaxseed oilAnti-inflammatory approachesAnti-inflammatory propertiesChronic physical exerciseImpact of exerciseType 2 diabetesInflammatory markersInflammatory responseExercise performanceHepatic metabolismGPR120Fat depotsSources of ω3GPR40ObesityLiverΒ-arrestinMiceRelated cascadesExerciseInsulin
2017
Hippocampal insulin signaling and neuroprotection mediated by physical exercise in Alzheimer´s Disease
Kuga G, Botezelli J, Gaspar R, Gomes R, Pauli J, de Almeida Leme J. Hippocampal insulin signaling and neuroprotection mediated by physical exercise in Alzheimer´s Disease. Motriz Revista De Educação Física 2017, 23: e101608. DOI: 10.1590/s1980-6574201700si0008.Peer-Reviewed Original ResearchTreatment of ADAlzheimer's diseaseNeuronal survivalLow-grade inflammationAnti-inflammatory effectsNon-pharmacological alternativesAD genesisHippocampal insulinHippocampal neurodegenerationHippocampal neuroprotectionNeuroprotective mechanismsInsulin sensitivityEpidemiological studiesPhysical exerciseHippocampal integrityDiseaseInsulinNeuroprotectionExercisePreventionMolecular mechanismsSurvivalTreatmentIntense research effortsPowerful activator