Autonomic reactivity to mental stress is associated with cardiovascular mortality
Shah A, Vaccarino V, Moazzami K, Almuwaqqat Z, Garcia M, Ward L, Elon L, Ko Y, Sun Y, Pearce B, Raggi P, Bremner J, Lampert R, Quyyumi A, Shah A. Autonomic reactivity to mental stress is associated with cardiovascular mortality. European Heart Journal Open 2024, 4: oeae086. PMID: 39588213, PMCID: PMC11588410, DOI: 10.1093/ehjopen/oeae086.Peer-Reviewed Original ResearchHazard ratioCardiovascular diseaseHigher CVD mortality riskAssociated with CVD mortalityHeart rate variabilityCardiovascular disease risk factorsCVD mortality riskCardiovascular disease mortalityCardiovascular disease deathsCardiovascular disease outcomesCause-specific survival modelsAssociated with cardiovascular mortalityAll-cause mortalityCVD causeAssociated with HRCVD mortalityMental stress testMeasure of autonomic dysfunctionMortality riskAssess autonomic functionAutonomic dysfunctionCardiovascular mortalityStable cardiovascular diseaseRisk factorsPooled cohortHeart Rate Variability, Deceleration Capacity of Heart Rate, and Death: A Veteran Twins Study
Huang M, Shah A, Lampert R, Bliwise D, Johnson D, Clifford G, Sloan R, Goldberg J, Ko Y, Da Poian G, Perez‐Alday E, Almuwaqqat Z, Shah A, Garcia M, Young A, Moazzami K, Bremner J, Vaccarino V. Heart Rate Variability, Deceleration Capacity of Heart Rate, and Death: A Veteran Twins Study. Journal Of The American Heart Association 2024, 13: e032740. PMID: 38533972, PMCID: PMC11179789, DOI: 10.1161/jaha.123.032740.Peer-Reviewed Original ResearchConceptsLow-frequency heart rate variabilityHazard of deathAssociated with reduced mortality riskMortality riskMultivariable Cox frailty modelsHeart rate variabilityAssociated with decreased hazard of deathNational Death IndexDeceleration capacityAssociated with lower hazardWithin-pair analysesTwin studiesCox frailty modelsHazard ratio of deathRatio of deathDeceleration capacity of heart rateAssociated with decreased hazardDeath IndexHeart rateAll-cause deathHazard ratioFrequency domain heart rate variabilityStrong associations