Autonomic reactivity to mental stress is associated with cardiovascular mortality
Shah A, Vaccarino V, Moazzami K, Almuwaqqat Z, Garcia M, Ward L, Elon L, Ko Y, Sun Y, Pearce B, Raggi P, Bremner J, Lampert R, Quyyumi A, Shah A. Autonomic reactivity to mental stress is associated with cardiovascular mortality. European Heart Journal Open 2024, 4: oeae086. PMID: 39588213, PMCID: PMC11588410, DOI: 10.1093/ehjopen/oeae086.Peer-Reviewed Original ResearchHazard ratioCardiovascular diseaseHigher CVD mortality riskAssociated with CVD mortalityHeart rate variabilityCardiovascular disease risk factorsCVD mortality riskCardiovascular disease mortalityCardiovascular disease deathsCardiovascular disease outcomesCause-specific survival modelsAssociated with cardiovascular mortalityAll-cause mortalityCVD causeAssociated with HRCVD mortalityMental stress testMeasure of autonomic dysfunctionMortality riskAssess autonomic functionAutonomic dysfunctionCardiovascular mortalityStable cardiovascular diseaseRisk factorsPooled cohortStress-Induced Autonomic Dysfunction is Associated With Mental Stress–Induced Myocardial Ischemia in Patients With Coronary Artery Disease
Osei J, Vaccarino V, Wang M, Shah A, Lampert R, Li L, Ko Y, Pearce B, Kutner M, Garcia E, Piccinelli M, Raggi P, Bremner J, Quyyumi A, Sun Y, Ahmed H, Haddad G, Daaboul O, Roberts T, Stefanos L, Correia L, Shah A. Stress-Induced Autonomic Dysfunction is Associated With Mental Stress–Induced Myocardial Ischemia in Patients With Coronary Artery Disease. Circulation Cardiovascular Imaging 2024, 17: e016596. PMID: 38868952, PMCID: PMC11187646, DOI: 10.1161/circimaging.124.016596.Peer-Reviewed Original ResearchConceptsMental stress-induced myocardial ischemiaLow heart rate variabilityAssociated with MSIMICoronary artery diseaseAssociated with higher oddsStable coronary artery diseaseStress-induced myocardial ischemiaAutonomic dysfunctionLow-frequency heart rate variabilityArtery diseaseHeart rate variabilityHigher oddsHigher heart rate variabilityResponse to stressIndicator of autonomic dysfunctionMyocardial ischemiaSpeech stressorAssociated with adverse cardiovascular outcomesMultivariate logistic regression modelAssociation of autonomic dysfunctionAdverse cardiovascular outcomesLogistic regression modelsBlack participantsHolter monitoringClinical factors