2022
Interaction between maternal killer immunoglobulin-like receptors and offspring HLAs and susceptibility of childhood ALL
Feng Q, Zhou M, Li S, Morimoto L, Hansen H, Myint SS, Wang R, Metayer C, Kang A, Fear AL, Pappas D, Erlich H, Hollenbach JA, Mancuso N, Trachtenberg E, de Smith AJ, Ma X, Wiemels JL. Interaction between maternal killer immunoglobulin-like receptors and offspring HLAs and susceptibility of childhood ALL. Blood Advances 2022, 6: 3756-3766. PMID: 35500222, PMCID: PMC9631572, DOI: 10.1182/bloodadvances.2021006821.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesChildCytokinesHLA AntigensHumansImmunoglobulinsKiller Cells, NaturalPrecursor Cell Lymphoblastic Leukemia-LymphomaReceptors, KIRConceptsKiller immunoglobulin-like receptorsMaternal killer immunoglobulin-like receptorsAcute lymphoblastic leukemiaChild-mother pairsImmunoglobulin-like receptorsArginase IIKIR interactionsLower riskNon-Latino white subjectsLower tumor necrosisCase-control studyEtiology of childhoodDevelopment of childhoodHLA-KIRNeonatal cytokinesCytokine levelsCytokine profileLymphoblastic leukemiaImmune factorsImmune phenotypeTumor necrosisHigh riskChildhood leukemiaCytokine controlSignificant associationHispanic Ethnicity Differences in Birth Characteristics, Maternal Birthplace, and Risk of Early-Onset Hodgkin Lymphoma: A Population-Based Case–Control Study
Graham C, Metayer C, Morimoto LM, Wiemels JL, Siddique A, Di M, Rodwin RL, Kadan-Lottick NS, Ma X, Wang R. Hispanic Ethnicity Differences in Birth Characteristics, Maternal Birthplace, and Risk of Early-Onset Hodgkin Lymphoma: A Population-Based Case–Control Study. Cancer Epidemiology Biomarkers & Prevention 2022, 31: 1788-1795. PMID: 35709749, PMCID: PMC9444874, DOI: 10.1158/1055-9965.epi-22-0335.Peer-Reviewed Original ResearchConceptsNon-Hispanic whitesHodgkin's lymphomaCase-control studyBirth characteristicsMaternal birthplaceMaternal agePopulation-based case-control studyMultivariable logistic regression modelConfidence intervalsEthnic differencesEarly-onset cancersPotential ethnic differencesForeign-born mothersLogistic regression modelsEthnicity differencesRace/ethnicityYear of birthLymphomaPaternal ageFemale HispanicsHispanic casesMale HispanicsHodgkinAgeRiskMicroangiopathic Hemolytic Anemia Is a Late and Fatal Complication of Gastric Signet Ring Cell Carcinoma: A Systematic Review and Case-Control Study
Lam R, Tarangelo N, Wang R, Horibe M, Grimshaw AA, Jain D, Haffar S, Bazerbachi F, Kunz PL, Li DK. Microangiopathic Hemolytic Anemia Is a Late and Fatal Complication of Gastric Signet Ring Cell Carcinoma: A Systematic Review and Case-Control Study. The Oncologist 2022, 27: 751-759. PMID: 35589098, PMCID: PMC9438916, DOI: 10.1093/oncolo/oyac093.Peer-Reviewed Original ResearchMeSH KeywordsAnemia, HemolyticCarcinoma, Signet Ring CellCase-Control StudiesHumansPrognosisStomach NeoplasmsConceptsGastric signet ring cell carcinomaSignet ring cell carcinomaMicroangiopathic hemolytic anemiaHemolytic anemiaCell carcinomaMultivariable Cox proportional hazards regression modelingCox proportional hazards regression modelingSystematic reviewRare paraneoplastic syndromeStage-matched casesEnd Results (SEER) databaseLate-stage complicationsRisk of mortalityCase-control studyBone painParaneoplastic syndromeFatal complicationMedian survivalMetastatic diseaseOverall survivalLymph nodesIndex presentationPrognostic featuresResults databasePooled cohort
2021
Mode of Delivery, Birth Characteristics and Early-Onset Non-Hodgkin Lymphoma in a Population-Based Case-Control Study
Dwyer KE, Wang R, Cozen W, Cartmel B, Wiemels JL, Morimoto LM, Metayer C, Ma X. Mode of Delivery, Birth Characteristics and Early-Onset Non-Hodgkin Lymphoma in a Population-Based Case-Control Study. Cancer Epidemiology Biomarkers & Prevention 2021, 30: cebp.0535.2021. PMID: 34548330, DOI: 10.1158/1055-9965.epi-21-0535.Peer-Reviewed Original ResearchConceptsNon-Hodgkin lymphomaT-cell non-Hodgkin lymphomaCase-control studyBirth characteristicsMode of deliveryYear of birthOdds ratioNHL riskUnconditional multivariable logistic regression modelsPopulation-based case-control studyCases of NHLMultivariable logistic regression modelConfidence intervalsAge of diagnosisPediatric Burkitt lymphomaLogistic regression modelsCesarean sectionHistologic subtypeDecreased riskHodgkin's lymphomaMaternal ageBurkitt's lymphomaElevated riskLower riskMaternal educationProximity to endocrine-disrupting pesticides and risk of testicular germ cell tumors (TGCT) among adolescents: A population-based case-control study in California
Swartz SJ, Morimoto LM, Whitehead TP, DeRouen MC, Ma X, Wang R, Wiemels JL, McGlynn KA, Gunier R, Metayer C. Proximity to endocrine-disrupting pesticides and risk of testicular germ cell tumors (TGCT) among adolescents: A population-based case-control study in California. International Journal Of Hygiene And Environmental Health 2021, 239: 113881. PMID: 34839102, DOI: 10.1016/j.ijheh.2021.113881.Peer-Reviewed Original ResearchConceptsTesticular germ cell tumorsPopulation attributable riskGerm cell tumorsCase-control studyRace/ethnicityTGCT riskCell tumorsOdds ratioRegistry-based case-control studyPopulation-based case-control studyRisk of TGCTConfidence intervalsBirth yearYears of ageNeighborhood socioeconomic statusEndocrine-disrupting pesticidesFetal exposureCritical developmental periodAttributable riskCytokine Levels at Birth in Children Who Developed Acute Lymphoblastic Leukemia
Whitehead TP, Wiemels JL, Zhou M, Kang AY, McCoy LS, Wang R, Fitch B, Petrick LM, Yano Y, Imani P, Rappaport SM, Dahl GV, Kogan SC, Ma X, Metayer C. Cytokine Levels at Birth in Children Who Developed Acute Lymphoblastic Leukemia. Cancer Epidemiology Biomarkers & Prevention 2021, 30: 1526-1535. PMID: 34078642, PMCID: PMC8338848, DOI: 10.1158/1055-9965.epi-20-1704.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaCytokine levelsLymphoblastic leukemiaChildhood acute lymphoblastic leukemiaAberrant immune reactionsPrenatal immune developmentRisk of childhoodInterquartile range incrementAltered cytokine levelsCalifornia Childhood Leukemia StudyChildhood Leukemia StudyBirth characteristicsNeonatal levelsPrenatal exposureImmunomodulatory cytokinesImmune developmentHigh hyperdiploidyImmune reactionsCytokinesGM-CSFBlood spotsLogistic regressionLeukemia StudyEndogenous metabolitesConfidence intervals
2020
Birth Characteristics and Risk of Pediatric Thyroid Cancer: A Population-Based Record-Linkage Study in California
Deziel N, Zhang Y, Wang R, Wiemels JL, Morimoto L, Clark CJ, Metayer C, Ma X. Birth Characteristics and Risk of Pediatric Thyroid Cancer: A Population-Based Record-Linkage Study in California. Thyroid 2020, 31: 596-606. PMID: 32912083, PMCID: PMC8195873, DOI: 10.1089/thy.2020.0217.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge of OnsetBirth CertificatesBirth OrderBirth WeightCaliforniaCase-Control StudiesChildChild, PreschoolEducational StatusFemaleHispanic or LatinoHumansIncidenceInfantInfant, NewbornMaleRace FactorsRegistriesRisk AssessmentRisk FactorsSex FactorsThyroid NeoplasmsTime FactorsYoung AdultConceptsPediatric thyroid cancerHigh birth weightFollicular thyroid cancerThyroid cancerHigher birth orderBirth characteristicsRisk factorsHispanic ethnicityBirth weightOdds ratioFirst primary thyroid cancerPapillary thyroid cancer casesBirth orderMultivariable logistic regression modelSecond primary malignanciesLong-term therapyAdjusted odds ratioPopulation-based studyPrimary thyroid cancerRecord linkage studyConfidence intervalsImportant risk factorCancer registry dataCase-control studyThyroid cancer casesAge-, sex- and disease subtype–related foetal growth differentials in childhood acute myeloid leukaemia risk: A Childhood Leukemia International Consortium analysis
Karalexi MA, Dessypris N, Ma X, Spector LG, Marcotte E, Clavel J, Pombo-de-Oliveira MS, Heck JE, Roman E, Mueller BA, Hansen J, Auvinen A, Lee PC, Schüz J, Magnani C, Mora AM, Dockerty JD, Scheurer ME, Wang R, Bonaventure A, Kane E, Doody DR, Group N, Baka M, Moschovi M, Polychronopoulou S, Kourti M, Hatzipantelis E, Pelagiadis I, Dana H, Kantzanou M, Tzanoudaki M, Anastasiou T, Grenzelia M, Gavriilaki E, Sakellari I, Anagnostopoulos A, Kitra V, Paisiou A, Bouka E, Group F, Nikkilä A, Lohi O, Erdmann F, Kang A, Metayer C, Milne E, Petridou E. Age-, sex- and disease subtype–related foetal growth differentials in childhood acute myeloid leukaemia risk: A Childhood Leukemia International Consortium analysis. European Journal Of Cancer 2020, 130: 1-11. PMID: 32163883, DOI: 10.1016/j.ejca.2020.01.018.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsCase-Control StudiesChildChild, PreschoolFemaleFetal DevelopmentHumansInfantInfant, NewbornLeukemia, Myeloid, AcuteMaleSex FactorsConceptsAcute myeloid leukemiaChildhood Leukemia International ConsortiumGestational ageFoetal growthInfant boyAcute myeloid leukemia riskMyeloid leukemia riskNewborn Growth ConsortiumRare childhood cancerBirth lengthGrowth markersChildhood cancerAML subtypesAML casesMyeloid leukemiaLeukemia riskNull associationDisease subtypesInternational FetalAgeMore studiesConsortium analysisLeukemiaSexBoys
2019
Increased neonatal level of arginase 2 in cases of childhood acute lymphoblastic leukemia implicates immunosuppression in the etiology
Nielsen AB, Zhou M, de Smith AJ, Wang R, McCoy L, Hansen H, Morimoto L, Grønbæk K, Johansen C, Kogan SC, Metayer C, Bracci PM, Ma X, Wiemels JL. Increased neonatal level of arginase 2 in cases of childhood acute lymphoblastic leukemia implicates immunosuppression in the etiology. Haematologica 2019, 104: e514-e516. PMID: 30923090, PMCID: PMC6821599, DOI: 10.3324/haematol.2019.216465.Peer-Reviewed Original Research
2017
Parental Age and Risk of Pediatric Cancer in the Offspring: A Population-Based Record-Linkage Study in California
Wang R, Metayer C, Morimoto L, Wiemels JL, Yang J, DeWan AT, Kang A, Ma X. Parental Age and Risk of Pediatric Cancer in the Offspring: A Population-Based Record-Linkage Study in California. American Journal Of Epidemiology 2017, 186: 843-856. PMID: 28535175, PMCID: PMC5860074, DOI: 10.1093/aje/kwx160.Peer-Reviewed Original ResearchConceptsRecord linkage studyMaternal ageOdds ratioPediatric cancerParental agePopulation-based record linkage studyCentral nervous system tumorsRisk of lymphomaPopulation-based studyCancer registry dataNervous system tumorsRisk of leukemiaAge group 0Ages 0Pediatric cancer riskOlder paternal ageOlder age groupsTypes of cancerSystem tumorsRegistry dataCancer riskHigh riskGroup 0Birth recordsAge groups
2016
Cesarean Section and Risk of Childhood Acute Lymphoblastic Leukemia in a Population-Based, Record-Linkage Study in California
Wang R, Wiemels JL, Metayer C, Morimoto L, Francis SS, Kadan-Lottick N, DeWan AT, Zhang Y, Ma X. Cesarean Section and Risk of Childhood Acute Lymphoblastic Leukemia in a Population-Based, Record-Linkage Study in California. American Journal Of Epidemiology 2016, 185: 96-105. PMID: 27986703, PMCID: PMC5253971, DOI: 10.1093/aje/kww153.Peer-Reviewed Original ResearchConceptsElective C-sectionAcute lymphoblastic leukemiaChildhood acute lymphoblastic leukemiaC-sectionCesarean sectionLymphoblastic leukemiaHigh riskPopulation-based case-control studyPeak ageEmergency C-sectionRecord linkage studyCancer registry dataCase-control studyPotential risk factorsEtiology of childhoodRelationship of modeVaginal deliveryRisk factorsRole of deliveryRegistry dataElevated riskBirth recordsInaccurate recallChildhoodRisk
2014
Disease Risk Estimation by Combining Case–Control Data with Aggregated Information on the Population at Risk
Chang X, Waagepetersen R, Yu H, Ma X, Holford TR, Wang R, Guan Y. Disease Risk Estimation by Combining Case–Control Data with Aggregated Information on the Population at Risk. Biometrics 2014, 71: 114-121. PMID: 25351292, PMCID: PMC4782587, DOI: 10.1111/biom.12256.Peer-Reviewed Original ResearchConceptsCase-control dataUnbiased estimating equationsFinite sample performanceNovel statistical frameworkSummary statisticsAsymptotic propertiesPopulation Estimates ProgramStatistical frameworkSubstantive applicationsEstimating EquationsEquationsStatisticsStandard approachEstimationEstimates ProgramEstimatorRisk estimationSimulationsApproach
2008
Occupational Exposure to Solvents and Risk of Non-Hodgkin Lymphoma in Connecticut Women
Wang R, Zhang Y, Lan Q, Holford TR, Leaderer B, Zahm SH, Boyle P, Dosemeci M, Rothman N, Zhu Y, Qin Q, Zheng T. Occupational Exposure to Solvents and Risk of Non-Hodgkin Lymphoma in Connecticut Women. American Journal Of Epidemiology 2008, 169: 176-185. PMID: 19056833, PMCID: PMC2727253, DOI: 10.1093/aje/kwn300.Peer-Reviewed Original ResearchConceptsRisk of NHLNon-Hodgkin lymphomaOccupational exposureConnecticut womenPopulation-based case-control studyOverall non-Hodgkin lymphomaDiffuse large B-cell lymphomaLarge B-cell lymphomaCase-control studyB-cell lymphomaJob-exposure matrixIncident casesNHL subtypesBenzene exposureLymphomaRisk patternsWomenRiskExposureCarbon tetrachlorideAssociationBorderlineWork settingsLevelsStrong evidencePersonal Use of Hair Dye and the Risk of Certain Subtypes of Non-Hodgkin Lymphoma
Zhang Y, De Sanjose S, Bracci PM, Morton LM, Wang R, Brennan P, Hartge P, Boffetta P, Becker N, Maynadie M, Foretova L, Cocco P, Staines A, Holford T, Holly EA, Nieters A, Benavente Y, Bernstein L, Zahm SH, Zheng T. Personal Use of Hair Dye and the Risk of Certain Subtypes of Non-Hodgkin Lymphoma. American Journal Of Epidemiology 2008, 167: 1321-1331. PMID: 18408225, PMCID: PMC4025953, DOI: 10.1093/aje/kwn058.Peer-Reviewed Original ResearchConceptsRisk of FLNon-Hodgkin lymphomaHair dye usePersonal hair dye useCLL/SLLFollicular lymphomaHair dyesNHL subtypesChronic lymphocytic leukemia/small lymphocytic lymphomaRisk of NHLSmall lymphocytic lymphomaLymphocytic lymphomaNHL casesCertain subtypesLymphomaFL riskWomenSubtypesRiskPrevious studiesPersonal use
2007
Ultraviolet Radiation Exposure and Risk of Non-Hodgkin's Lymphoma
Zhang Y, Holford TR, Leaderer B, Boyle P, Zhu Y, Wang R, Zou K, Zhang B, Wise JP, Qin Q, Kilfoy B, Han J, Zheng T. Ultraviolet Radiation Exposure and Risk of Non-Hodgkin's Lymphoma. American Journal Of Epidemiology 2007, 165: 1255-1264. PMID: 17327216, DOI: 10.1093/aje/kwm020.Peer-Reviewed Original ResearchConceptsHodgkin's lymphomaLymphoma subtypesNon-Hodgkin lymphomaCase-control studyHodgkin lymphoma subtypesUltraviolet radiation exposureHighest tertileConnecticut womenSun exposureLymphomaRadiation exposureDuration of timeWomenSuntanRiskFurther investigationDurationExposureTertileYearsSubtypesMonthsFamily history of hematopoietic and non-hematopoietic malignancies and risk of non-Hodgkin lymphoma
Zhang Y, Wang R, Holford TR, Leaderer B, Zahm SH, Boyle P, Zhu Y, Qin Q, Zheng T. Family history of hematopoietic and non-hematopoietic malignancies and risk of non-Hodgkin lymphoma. Cancer Causes & Control 2007, 18: 351-359. PMID: 17206533, DOI: 10.1007/s10552-006-0088-5.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesConnecticutFemaleHumansLeukemiaLymphomaLymphoma, Non-HodgkinMedical History TakingRisk FactorsConceptsRisk of NHLNon-Hodgkin lymphomaFirst-degree relativesNon-hematopoietic malignanciesFamily historyNHL subtypesPopulation-based case-control studyUnconditional logistic regressionCase-control studyFamily cancer historyNHL overallIncident casesCancer historyConclusionsThe riskConnecticut womenMalignancyLymphomaLogistic regressionHematopoietic malignanciesLeukemiaWomenRiskSubtypesSiblingsCervix