2007
Tourette's Syndrome and Pharmacotherapy
van Wattum P, Leckman J. Tourette's Syndrome and Pharmacotherapy. 2007 DOI: 10.1002/9780470101001.hcn055.Peer-Reviewed Original Research
2001
Thermal Sensitivity in Tourette Syndrome: Preliminary Report
Scahill L, Lombroso P, Mack G, Van Wattum P, Zhang H, Vitale A, Leckman J. Thermal Sensitivity in Tourette Syndrome: Preliminary Report. Perceptual And Motor Skills 2001, 92: 419-432. PMID: 11361302, DOI: 10.2466/pms.2001.92.2.419.Peer-Reviewed Original ResearchConceptsTourette syndromeSubgroup of patientsAge of onsetAdult male subjectsCurrent ageTic symptomsDopaminergic pathwaysSex distributionCurrent severityMale subjectsMean differenceSyndromeControl periodPreliminary reportSweat rateAgeSymptomsSubjectsOverall courseDegrees COnsetPatientsIllnessSeverityCourse
2000
Patterns of response to acute naloxone infusion in Tourette's syndrome
van Wattum P, Chappell P, Zelterman D, Scahill L, Leckman J. Patterns of response to acute naloxone infusion in Tourette's syndrome. Movement Disorders 2000, 15: 1252-1254. PMID: 11104215, DOI: 10.1002/1531-8257(200011)15:6<1252::aid-mds1030>3.0.co;2-i.Peer-Reviewed Original ResearchConceptsTourette syndromeTic behaviorsOpioid antagonist naloxoneDose-related effectsDose-response effectExpression of TSRandomized dosesAntagonist naloxoneNaloxone infusionOpioid receptorsLow doseHigh doseEarlier pilot studyPattern of responseSyndromeNaloxoneTS subjectsPilot studySignificant decreaseSignificant increaseDoseDifferent dosagesOpposite effectSubjectsVideotaped recordings