2024
Illusory generalizability of clinical prediction models
Chekroud A, Hawrilenko M, Loho H, Bondar J, Gueorguieva R, Hasan A, Kambeitz J, Corlett P, Koutsouleris N, Krumholz H, Krystal J, Paulus M. Illusory generalizability of clinical prediction models. Science 2024, 383: 164-167. PMID: 38207039, DOI: 10.1126/science.adg8538.Peer-Reviewed Original Research
2023
Phenomenological and Cognitive Features Associated With Auditory Hallucinations in Clinical and Nonclinical Voice Hearers
Gold J, Corlett P, Erickson M, Waltz J, August S, Dutterer J, Bansal S. Phenomenological and Cognitive Features Associated With Auditory Hallucinations in Clinical and Nonclinical Voice Hearers. Schizophrenia Bulletin 2023, 49: 1591-1601. PMID: 37350507, PMCID: PMC10686332, DOI: 10.1093/schbul/sbad083.Peer-Reviewed Original ResearchConceptsAuditory verbal hallucinationsVoice hearersUnusual beliefsExperience of AVHNegative symptomsDSM-V diagnosisFeatures of schizophreniaMotivational deficitsCognitive featuresBroad batteryVerbal hallucinationsDelusional beliefsSZ/schizoaffective disorderCognitive AssessmentLess distressSensory featuresCognitive deficitsFirst-rank symptomsBroader phenotypeAuditory hallucinationsCognitive impairmentSchizoaffective disorderSchizophreniaBeliefsDeficitsUsing dimensionality-reduction techniques to understand the organization of psychotic symptoms in persistent psychotic illness and first episode psychosis
Fleming L, Lemonde A, Benrimoh D, Gold J, Taylor J, Malla A, Joober R, Iyer S, Lepage M, Shah J, Corlett P. Using dimensionality-reduction techniques to understand the organization of psychotic symptoms in persistent psychotic illness and first episode psychosis. Scientific Reports 2023, 13: 4841. PMID: 36964175, PMCID: PMC10039017, DOI: 10.1038/s41598-023-31909-w.Peer-Reviewed Original ResearchConceptsHallucinations/delusionsFirst-episode psychosisFirst-episode psychosis participantsEarly intervention programsPathophysiological mechanismsUnderlying pathophysiologyEpisode psychosisPsychotic illnessPsychotic symptomsPsychotic disordersSchizoaffective disorderAuditory hallucinationsPositive symptomsHallucination severityNegative symptomsSymptomsDisorganization symptomsIntervention programsHallucinationsIllnessPsychosis participantsPsychosisDelusionsDisordersParticipants
2012
NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia
Anticevic A, Gancsos M, Murray JD, Repovs G, Driesen NR, Ennis DJ, Niciu MJ, Morgan PT, Surti TS, Bloch MH, Ramani R, Smith MA, Wang XJ, Krystal JH, Corlett PR. NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 16720-16725. PMID: 23012427, PMCID: PMC3478611, DOI: 10.1073/pnas.1208494109.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlgorithmsBrainCognitionDouble-Blind MethodExcitatory Amino Acid AntagonistsFemaleHumansInfusions, IntravenousKetamineMagnetic Resonance ImagingMaleMemoryModels, NeurologicalPattern Recognition, VisualPsychomotor PerformanceReceptors, N-Methyl-D-AspartateSchizophreniaSynaptic TransmissionYoung AdultConceptsNeural systemsLarge-scale brain systemsTask-dependent activationN-methyl-D-aspartate receptorsRealistic computational modelingSevere neuropsychiatric illnessNMDA glutamate receptor antagonistGlutamate receptor antagonistsBrain systemsNMDA receptor functionTask performanceMultiple interacting regionsCognitionCortical disinhibitionGlutamatergic neurotransmissionReceptor antagonistCortical computationGlutamate's roleReciprocal relationshipNeuropsychiatric illnessLocal circuitsReceptor functionSchizophreniaPresent findingsComputational modeling
2005
Functional dysconnectivity in schizophrenia associated with attentional modulation of motor function
Honey G, Pomarol-Clotet E, Corlett P, Honey R, Mckenna P, Bullmore E, Fletcher P. Functional dysconnectivity in schizophrenia associated with attentional modulation of motor function. Brain 2005, 128: 2597-2611. PMID: 16183659, PMCID: PMC3838931, DOI: 10.1093/brain/awh632.Peer-Reviewed Original ResearchConceptsCognitive dysmetria hypothesisPatient groupAnterior cingulateFunctional MRIContinuous performance taskFunctional dysconnectivitySchizophrenia patientsPositive symptomsNegative symptomsMedial superior frontal gyrusThalamo-cortical circuitsDistinct symptom profilesSupplementary motor areaCases of schizophreniaSuperior frontal gyrusFunctional imaging studiesTask-related connectivityGroups of subjectsIllness onsetControl subjectsFunctional deficitsMotor functionHealthy volunteersMotor areaFundamental abnormality