Epicutaneous Immunization with Protein Antigen in the Presence of TLR4 Ligand Induces TCRαβ+CD4+ T Contrasuppressor Cells That Reverse Skin-Induced Suppression of Th1-Mediated Contact Sensitivity
Ptak W, Majewska M, Bryniarski K, Ptak M, Lobo FM, Zając K, Askenase PW, Szczepanik M. Epicutaneous Immunization with Protein Antigen in the Presence of TLR4 Ligand Induces TCRαβ+CD4+ T Contrasuppressor Cells That Reverse Skin-Induced Suppression of Th1-Mediated Contact Sensitivity. The Journal Of Immunology 2009, 182: 837-850. PMID: 19124727, DOI: 10.4049/jimmunol.182.2.837.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, CutaneousAnimalsCD4-Positive T-LymphocytesCells, CulturedContraindicationsDermatitis, ContactImmune ToleranceImmunizationLigandsLipopolysaccharidesMaleMiceMice, Inbred BALB CMice, Inbred CBAMice, KnockoutMice, TransgenicPatch TestsReceptors, Antigen, T-Cell, alpha-betaSkinTh1 CellsToll-Like Receptor 4TrinitrobenzenesConceptsEpicutaneous immunizationEffector cellsIL-12Effector phaseT cellsIFN-gammaTC cellsContrasuppressor T cellsCS effector cellsIL-12 neutralizationSkin-induced suppressionContact sensitivity reactionTh1 effector cellsTLR4 ligand LPSMechanism of actionEC immunizationSuppressor CD4Th1 CD4Regulatory cellsRIL-12TLR4 ligandIL-6Contact sensitivityLigand LPSINF-gamma