2013
Antigen-specific, antibody-coated, exosome-like nanovesicles deliver suppressor T-cell microRNA-150 to effector T cells to inhibit contact sensitivity
Bryniarski K, Ptak W, Jayakumar A, Püllmann K, Caplan MJ, Chairoungdua A, Lu J, Adams BD, Sikora E, Nazimek K, Marquez S, Kleinstein SH, Sangwung P, Iwakiri Y, Delgato E, Redegeld F, Blokhuis BR, Wojcikowski J, Daniel AW, Kormelink T, Askenase PW. Antigen-specific, antibody-coated, exosome-like nanovesicles deliver suppressor T-cell microRNA-150 to effector T cells to inhibit contact sensitivity. Journal Of Allergy And Clinical Immunology 2013, 132: 170-181.e9. PMID: 23727037, PMCID: PMC4176620, DOI: 10.1016/j.jaci.2013.04.048.Peer-Reviewed Original ResearchConceptsCutaneous contact sensitivityEffector T cellsT cell toleranceT cellsExosome-like nanovesiclesContact sensitivityCS-effector T cellsMiRNA-150Regulatory T cellsAntigen-specific mannerSuppressor T cellsRole of antibodiesAdoptive cell transfer modelCell transfer modelT cell regulationLight chainSuppressor cellsLymph nodesReactive haptenImmune suppressionMicroRNA-150Systemic injectionAntibody light chainIntravenous injectionSpleen cells
1996
Delayed-type hypersensitivity in mast cell-deficient mice: dependence on platelets for expression of contact sensitivity.
Geba GP, Ptak W, Anderson GM, Paliwal V, Ratzlaff RE, Levin J, Askenase PW. Delayed-type hypersensitivity in mast cell-deficient mice: dependence on platelets for expression of contact sensitivity. The Journal Of Immunology 1996, 157: 557-65. PMID: 8752902, DOI: 10.4049/jimmunol.157.2.557.Peer-Reviewed Original ResearchConceptsMast cell-deficient miceCell-deficient miceDelayed-type hypersensitivityContact sensitivityPlatelet depletionMast cellsCS responsesT cell-mediated immune responsesMast cell-deficient strainsDelayed-type hypersensitivity responseT cell-mediated responsesCell-mediated immune responsesTissue levelsCutaneous sensitivity responsesVasoactive amine serotoninCell-mediated responsesLocal mast cellsMast cell numbersNormal mast cell numbersHypersensitivity responseCutaneous responseImmunologic evidenceBeige miceImmune responseAmine serotonin
1979
Involvement of host Fc receptors in antibody-mediated cutaneous basophil hypersensitivity reactions.
Graziano F, Askenase P. Involvement of host Fc receptors in antibody-mediated cutaneous basophil hypersensitivity reactions. The Journal Of Immunology 1979, 123: 1645-52. PMID: 90094, DOI: 10.4049/jimmunol.123.4.1645.Peer-Reviewed Original ResearchConceptsPassive cutaneous anaphylaxisCutaneous basophil hypersensitivityFc receptorsT cellsGuinea pig immune serumBinding to Fc receptorsGamma-globulinCutaneous mast cellsCutaneous basophil hypersensitivity reactionPurified Fc fragmentsB cellsFc fragmentSecretion of moleculesCutaneous responseRabbit IgGHypersensitivity reactionsBovine gamma globulinConcurrent inhibitionGuinea pigsMast cellsSerum antibodiesCutaneous anaphylaxisHeterologous gamma globulinImmune serumSerum
1978
A newly described activity of guinea pig IgG1 antibodies: transfer of cutaneous basophil reactions.
Haynes J, Rosenstein R, Askenase P. A newly described activity of guinea pig IgG1 antibodies: transfer of cutaneous basophil reactions. The Journal Of Immunology 1978, 120: 886-94. PMID: 344798, DOI: 10.4049/jimmunol.120.3.886.Peer-Reviewed Original Research