1979
Involvement of host Fc receptors in antibody-mediated cutaneous basophil hypersensitivity reactions.
Graziano F, Askenase P. Involvement of host Fc receptors in antibody-mediated cutaneous basophil hypersensitivity reactions. The Journal Of Immunology 1979, 123: 1645-52. PMID: 90094, DOI: 10.4049/jimmunol.123.4.1645.Peer-Reviewed Original ResearchConceptsPassive cutaneous anaphylaxisCutaneous basophil hypersensitivityFc receptorsT cellsGuinea pig immune serumBinding to Fc receptorsGamma-globulinCutaneous mast cellsCutaneous basophil hypersensitivity reactionPurified Fc fragmentsB cellsFc fragmentSecretion of moleculesCutaneous responseRabbit IgGHypersensitivity reactionsBovine gamma globulinConcurrent inhibitionGuinea pigsMast cellsSerum antibodiesCutaneous anaphylaxisHeterologous gamma globulinImmune serumSerum
1978
A newly described activity of guinea pig IgG1 antibodies: transfer of cutaneous basophil reactions.
Haynes J, Rosenstein R, Askenase P. A newly described activity of guinea pig IgG1 antibodies: transfer of cutaneous basophil reactions. The Journal Of Immunology 1978, 120: 886-94. PMID: 344798, DOI: 10.4049/jimmunol.120.3.886.Peer-Reviewed Original ResearchColonic basophil hypersensitivity.
Askenase P, Boone W, Binder H. Colonic basophil hypersensitivity. The Journal Of Immunology 1978, 120: 198-301. PMID: 627717, DOI: 10.4049/jimmunol.120.1.198.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBasophilsColonCroton OilDinitrochlorobenzeneGuinea PigsHypersensitivity, DelayedInflammationConceptsHypersensitivity reactionsInflammatory responseColon of guinea pigsContact hypersensitivity reactionApplication of DNCBColonic inflammatory responseInfiltration of basophilsInflammatory bowel diseaseImmune inflammatory responseStudy of inflammatory bowel diseaseContact sensitivityIntraluminal applicationBowel diseaseGuinea pigsCroton oilDNCBColon
1977
Studies on the role of the thymus and T cells in the in vivo suppression of delayed hypersensitivity (desensitization): radiosensitivity of the mechanism inducing nonspecific anergy.
Thestrup-Pedersen K, Dwyer J, Askenase P. Studies on the role of the thymus and T cells in the in vivo suppression of delayed hypersensitivity (desensitization): radiosensitivity of the mechanism inducing nonspecific anergy. The Journal Of Immunology 1977, 118: 1665-71. PMID: 300755, DOI: 10.4049/jimmunol.118.5.1665.Peer-Reviewed Original ResearchConceptsT cellsDelayed hypersensitivitySuppression of delayed hypersensitivityDoses of whole-body irradiationNonspecific desensitizationMature T cellsWhole-body irradiationMono-nuclear cellsIn vivo suppressionThymic weightImmunoregulatory mechanismsPeripheral bloodRadiosensitive cellsAssociated with 1AnergySmall dosesDecreased responseGuinea pigsSkin sitesDesensitizationAntigenDesensitized stateConcanavalin AHypersensitivityCellsCuta neous basophil responses in neonatal guinea pigs: active immunization, hapten specific transfer with small amounts of serum, and preferential elicitation with phytohemagglutinin skin testing.
Haynes J, Askenase P. Cuta neous basophil responses in neonatal guinea pigs: active immunization, hapten specific transfer with small amounts of serum, and preferential elicitation with phytohemagglutinin skin testing. The Journal Of Immunology 1977, 118: 1063-9. PMID: 845431, DOI: 10.4049/jimmunol.118.3.1063.Peer-Reviewed Original ResearchConceptsNeonatal guinea pigsIncomplete Freund's adjuvantMononuclear cellsCutaneous basophil hypersensitivityGuinea pigsBasophil responsePPD reactionSkin testFreund's adjuvantDelayed skin test responsesDelayed hypersensitivity skin responseHapten-specific mannerNonimmune guinea pigsDelayed-type reactionsSkin test responsesInfiltration of eosinophilsAdult guinea pigsCutaneous basophil responseIntravenous transferCutaneous basophil hypersensitivity reactionNeonatal responsesAdult donorsCutaneous reactionsNeonatesHapten-carrier conjugates
1976
Cutaneous basophil hypersensitivity uncovered in the cell transfer of classical tuberculin hypersensitivity.
Askenase P. Cutaneous basophil hypersensitivity uncovered in the cell transfer of classical tuberculin hypersensitivity. The Journal Of Immunology 1976, 117: 741-7. PMID: 1085308, DOI: 10.4049/jimmunol.117.3.741.Peer-Reviewed Original ResearchConceptsCell transferIncomplete Freund's adjuvantSkin reactionsCutaneous basophil hypersensitivityGuinea pigsRecipients of cellsNylon wool columnsCell transfer recipientsDelayed skin reactionsT cellsSkin testBasophil responseFreund's adjuvantCellular transferTuberculin hypersensitivitySensitization of recipientsWool columnsBasophil infiltrationHumoral factorsBasophil numbersPassive transferHypersensitivityRecipientsBasophilsDelayed reactionsAntibody-mediated basophil accumulations in cutaneous hypersensitivity reactions of guinea pigs.
Askenase P, Haynes J, Hayden B. Antibody-mediated basophil accumulations in cutaneous hypersensitivity reactions of guinea pigs. The Journal Of Immunology 1976, 117: 216-24. PMID: 932424, DOI: 10.4049/jimmunol.117.1.216.Peer-Reviewed Original ResearchConceptsCutaneous basophil hypersensitivityCutaneous hypersensitivity reactionsGuinea pigsDelayed hypersensitivityBasophil accumulationProduction of B lymphocytesCutaneous basophil hypersensitivity reactionT lymphocytesKeyhole limpet hemocyanin (KLHB lymphocytesIntradermal injectionDonors 1 weekHypersensitive responseHypersensitivity reactionsPigsSerum antibodiesAntibody production of B lymphocytesHypersensitivityBasophil reactionsImmune serumAntibody productionSerum