Molecular regulation of tumor necrosis factor-alpha and lymphotoxin production in T cells. Inhibition by prostaglandin E2.
Ferreri NR, Sarr T, Askenase PW, Ruddle NH. Molecular regulation of tumor necrosis factor-alpha and lymphotoxin production in T cells. Inhibition by prostaglandin E2. Journal Of Biological Chemistry 1992, 267: 9443-9449. PMID: 1533632, DOI: 10.1016/s0021-9258(19)50443-4.Peer-Reviewed Original ResearchConceptsTNF-alphaProstaglandin E2T cell clonesT cellsTumor necrosisLymphotoxin productionLT productionMajor histocompatibility complex class IIHistocompatibility complex class IICell clonesPresence of PGE2M prostaglandin E2Dose-dependent mannerPGF2 alphaSoluble concanavalin ALeukotriene C4Murine Th1Inhibited productionClass IIFibrosarcoma cell lineInhibitory effectMurine fibrosarcoma cell lineBiological activityConcanavalin ACell lines