2021
Antibodies Enhance the Suppressive Activity of Extracellular Vesicles in Mouse Delayed-Type Hypersensitivity
Nazimek K, Bustos-Morán E, Blas-Rus N, Nowak B, Totoń-Żurańska J, Seweryn MT, Wołkow P, Woźnicka O, Szatanek R, Siedlar M, Askenase PW, Sánchez-Madrid F, Bryniarski K. Antibodies Enhance the Suppressive Activity of Extracellular Vesicles in Mouse Delayed-Type Hypersensitivity. Pharmaceuticals 2021, 14: 734. PMID: 34451831, PMCID: PMC8398949, DOI: 10.3390/ph14080734.Peer-Reviewed Original ResearchDelayed-type hypersensitivityMice delayed-type hypersensitivityAntigen-specific antibodiesEffector T cellsT cellsSuppressive activityExtracellular vesiclesAntigen-presenting macrophagesMHC class IIGreat therapeutic potentialMouse modelSuppressive actionCurrent studyMiRNA-150Therapeutic potentialClass IIFlow cytometryExact mechanismAntibodiesParental cellsTherapeutic usageHypersensitivityMacrophagesIntercellular communicationSpecific binding
1992
Molecular regulation of tumor necrosis factor-alpha and lymphotoxin production in T cells. Inhibition by prostaglandin E2.
Ferreri NR, Sarr T, Askenase PW, Ruddle NH. Molecular regulation of tumor necrosis factor-alpha and lymphotoxin production in T cells. Inhibition by prostaglandin E2. Journal Of Biological Chemistry 1992, 267: 9443-9449. PMID: 1533632, DOI: 10.1016/s0021-9258(19)50443-4.Peer-Reviewed Original ResearchConceptsTNF-alphaProstaglandin E2T cell clonesT cellsTumor necrosisLymphotoxin productionLT productionMajor histocompatibility complex class IIHistocompatibility complex class IICell clonesPresence of PGE2M prostaglandin E2Dose-dependent mannerPGF2 alphaSoluble concanavalin ALeukotriene C4Murine Th1Inhibited productionClass IIFibrosarcoma cell lineInhibitory effectMurine fibrosarcoma cell lineBiological activityConcanavalin ACell lines