Dietary Methyl Donor Depletion Protects Against Intestinal Tumorigenesis in ApcMin/+ Mice
Kadaveru K, Protiva P, Greenspan EJ, Kim YI, Rosenberg DW. Dietary Methyl Donor Depletion Protects Against Intestinal Tumorigenesis in ApcMin/+ Mice. Cancer Prevention Research 2012, 5: 911-920. PMID: 22677908, PMCID: PMC3397832, DOI: 10.1158/1940-6207.capr-11-0544.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomarkers, TumorCaloric RestrictionDietFolic AcidFolic Acid DeficiencyGene Expression ProfilingGenes, APCHumansIntestinal NeoplasmsMiceMice, Inbred C57BLOligonucleotide Array Sequence AnalysisReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSignal TransductionConceptsWeeks of ageIntestinal tumorigenesisCancer protectionNormal-appearing colonic mucosaMethyl donor statusSmall intestinal tumorsHigh-risk populationDietary folate supplementationVitamin B12 depletionColon cancer riskIntestinal tumor formationBody weight gainMD miceTumor numberTumor sizeMDS groupIntestinal tumorsColonic mucosaFolate supplementationProtective effectB12 depletionInflammatory signalingCancer riskDeficient dietFolate deficiency