2016
Modafinil and sleep architecture in an inpatient–outpatient treatment study of cocaine dependence
Morgan PT, Angarita GA, Canavan S, Pittman B, Oberleitner L, Malison RT, Mohsenin V, Hodges S, Easton C, McKee S, Bessette A, Forselius E. Modafinil and sleep architecture in an inpatient–outpatient treatment study of cocaine dependence. Drug And Alcohol Dependence 2016, 160: 49-56. PMID: 26777774, PMCID: PMC4767553, DOI: 10.1016/j.drugalcdep.2015.12.004.Peer-Reviewed Original ResearchConceptsUrine toxicology screenModafinil treatmentSlow-wave sleepClinical outcomesOutpatient treatmentToxicology screenUrine screensInpatient settingInpatient treatmentSleep timeCocaine dependencePrimary clinical outcomeWeekly cognitive behavioral therapyCocaine usersImproved clinical outcomesPolysomnographic sleep recordingsChronic cocaine useChronic cocaine usersHigh rateCognitive behavioral therapyCocaine-dependent participantsSleep architectureOutpatient phaseEffective treatmentDays abstinent
2012
Guanfacine effects on stress, drug craving and prefrontal activation in cocaine dependent individuals: preliminary findings
Fox HC, Seo D, Tuit K, Hansen J, Kimmerling A, Morgan PT, Sinha R. Guanfacine effects on stress, drug craving and prefrontal activation in cocaine dependent individuals: preliminary findings. Journal Of Psychopharmacology 2012, 26: 958-972. PMID: 22234929, PMCID: PMC3694403, DOI: 10.1177/0269881111430746.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic alpha-2 Receptor AgonistsAdultCocaine-Related DisordersCombined Modality TherapyConnecticutDiagnostic and Statistical Manual of Mental DisordersDose-Response Relationship, DrugDouble-Blind MethodFemaleGuanfacineHumansImagery, PsychotherapyMagnetic Resonance ImagingMaleMiddle AgedNeuronsPilot ProjectsPrefrontal CortexStress, PsychologicalSubstance Withdrawal SyndromeConceptsCocaine-dependent individualsPrefrontal activityDrug cravingFunctional magnetic resonance imaging sessionDrug cue-induced cravingTreatment-seeking cocaine dependent individualsCue-induced drug cravingDependent individualsMagnetic resonance imaging sessionLateral prefrontal activityCue-induced cravingDrug cue exposureGuanfacine's effectsDrug cuesSubjective cravingImagery conditionPrefrontal activationCue exposurePhysiological arousalCognitive challengesBrain responsesAgonist guanfacineNicotine cravingGuanfacine groupCraving