2016
Sleep Perception and Misperception in Chronic Cocaine Users During Abstinence
Hodges SE, Pittman B, Morgan PT. Sleep Perception and Misperception in Chronic Cocaine Users During Abstinence. Sleep 2016, 40: zsw069. PMID: 28364419, PMCID: PMC5806585, DOI: 10.1093/sleep/zsw069.Peer-Reviewed Original ResearchConceptsChronic cocaine usersSleep state misperceptionWeeks of abstinenceTotal sleep timeOccult insomniaCocaine usersState misperceptionSleep onsetSleep timeCocaine-dependent personsInpatient research facilitySleep latencyDiary questionnairesSleep perceptionPolysomnographic sleep recordingsDiary measurementsAbstinenceTreatment studiesFinal awakeningMisperceptionsNight 3Objective worseningParticipantsInsomniaSleep recordingsSleep abnormalities associated with alcohol, cannabis, cocaine, and opiate use: a comprehensive review
Angarita GA, Emadi N, Hodges S, Morgan PT. Sleep abnormalities associated with alcohol, cannabis, cocaine, and opiate use: a comprehensive review. Addiction Science & Clinical Practice 2016, 11: 9. PMID: 27117064, PMCID: PMC4845302, DOI: 10.1186/s13722-016-0056-7.Peer-Reviewed Original ResearchMeSH KeywordsAlcoholismCocaine-Related DisordersHumansHypnotics and SedativesMarijuana AbuseOpioid-Related DisordersSleep StagesSleep Wake DisordersSubstance-Related DisordersModafinil and sleep architecture in an inpatient–outpatient treatment study of cocaine dependence
Morgan PT, Angarita GA, Canavan S, Pittman B, Oberleitner L, Malison RT, Mohsenin V, Hodges S, Easton C, McKee S, Bessette A, Forselius E. Modafinil and sleep architecture in an inpatient–outpatient treatment study of cocaine dependence. Drug And Alcohol Dependence 2016, 160: 49-56. PMID: 26777774, PMCID: PMC4767553, DOI: 10.1016/j.drugalcdep.2015.12.004.Peer-Reviewed Original ResearchConceptsUrine toxicology screenModafinil treatmentSlow-wave sleepClinical outcomesOutpatient treatmentToxicology screenUrine screensInpatient settingInpatient treatmentSleep timeCocaine dependencePrimary clinical outcomeWeekly cognitive behavioral therapyCocaine usersImproved clinical outcomesPolysomnographic sleep recordingsChronic cocaine useChronic cocaine usersHigh rateCognitive behavioral therapyCocaine-dependent participantsSleep architectureOutpatient phaseEffective treatmentDays abstinent
2014
Effects of endogenous and exogenous progesterone on emotional intelligence in cocaine‐dependent men and women who also abuse alcohol
Milivojevic V, Sinha R, Morgan PT, Sofuoglu M, Fox HC. Effects of endogenous and exogenous progesterone on emotional intelligence in cocaine‐dependent men and women who also abuse alcohol. Human Psychopharmacology Clinical And Experimental 2014, 29: 589-598. PMID: 25363303, PMCID: PMC4498951, DOI: 10.1002/hup.2446.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholismCocaine-Related DisordersEmotional IntelligenceEmotionsFemaleHumansMaleMenstrual CycleProgesteronePsychological TestsPsychotropic DrugsSex CharacteristicsConceptsEmotional intelligenceStudy 1Caruso Emotional Intelligence TestAbstinent cocaine-dependent individualsEmotional Intelligence TestRegulation of emotionCocaine-dependent individualsCocaine-dependent menFunction of genderManaging emotionsIntelligence testsEmotionsSelective aspectsSubstance dependenceGender effectsSex differencesMenstrual cycle phaseIntelligenceGender discrepancyMSCEITSaloveyImproved abilityIndividualsGonadal hormonesHealthy individualsCorrelates of polysomnographic sleep changes in cocaine dependence: Self-administration and clinical outcomes
Angarita GA, Canavan SV, Forselius E, Bessette A, Morgan PT. Correlates of polysomnographic sleep changes in cocaine dependence: Self-administration and clinical outcomes. Drug And Alcohol Dependence 2014, 143: 173-180. PMID: 25124303, PMCID: PMC4207081, DOI: 10.1016/j.drugalcdep.2014.07.025.Peer-Reviewed Original ResearchConceptsClinical outcomesWithdrawal symptomsNegative urineAmount of cocaineCocaine dependenceInpatient stayDays abstinentRapid eye movement (REM) sleepWeekly cognitive behavioral therapyCocaine self-administration studiesRandomized clinical trialsAbnormal sleep architectureEye movement sleepCocaine self-administration sessionsTotal sleep timeSlow-wave sleepChronic cocaine useSelf-administration sessionsSelf-administration studiesCognitive behavioral therapyRelevance of sleepPlacebo armSelf-reported useMovement sleepOutpatient treatmentPreliminary evidence for normalization of risk taking by modafinil in chronic cocaine users
Canavan SV, Forselius EL, Bessette AJ, Morgan PT. Preliminary evidence for normalization of risk taking by modafinil in chronic cocaine users. Addictive Behaviors 2014, 39: 1057-1061. PMID: 24642345, PMCID: PMC4026273, DOI: 10.1016/j.addbeh.2014.02.015.Peer-Reviewed Original ResearchConceptsBalloon Analogue Risk TaskBART scoresHealthy participantsCocaine-dependent individualsCocaine dependenceChronic cocaine usersEffects of modafinilCognitive effectsRisk TaskBehavioral measuresChronic cocaine useDependent individualsWake-promoting agentNormalization of riskRisk takingSubstance useCognitive impairmentPreliminary evidenceCocaine usersHigher scoresModafinilParticipantsCocaine useSleep disordersModafinil treatmentSex Differences in Guanfacine Effects on Drug Craving and Stress Arousal in Cocaine-Dependent Individuals
Fox HC, Morgan PT, Sinha R. Sex Differences in Guanfacine Effects on Drug Craving and Stress Arousal in Cocaine-Dependent Individuals. Neuropsychopharmacology 2014, 39: 1527-1537. PMID: 24395021, PMCID: PMC3988558, DOI: 10.1038/npp.2014.1.Peer-Reviewed Original ResearchConceptsCocaine use disorderImagery conditionNegative emotionsDrug cravingUse disordersCocaine-dependent individualsCocaine-dependent malesCocaine-dependent menSex differencesGuanfacine's effectsDrug cuesImagery exposureNegative moodSystolic blood pressureStress arousalNicotine cravingAlcohol cravingCounterbalanced orderCravingCocaine cravingAnxietyCocaine addictionEmotionsRecovery time pointsGuanfacine
2013
Abstinence-related changes in sleep during treatment for cocaine dependence
Angarita GA, Canavan SV, Forselius E, Bessette A, Pittman B, Morgan PT. Abstinence-related changes in sleep during treatment for cocaine dependence. Drug And Alcohol Dependence 2013, 134: 343-347. PMID: 24315572, PMCID: PMC4396819, DOI: 10.1016/j.drugalcdep.2013.11.007.Peer-Reviewed Original ResearchMeSH KeywordsAdultCocaine-Related DisordersCognitive Behavioral TherapyCohort StudiesFemaleHumansMaleMiddle AgedPolysomnographySleepSubstance Withdrawal SyndromeTreatment OutcomeConceptsTotal sleep timeExtended abstinenceOutpatient cognitive behavioral therapyAbstinence-related changesDecreased slow wave sleepInpatient substance abuse treatmentCognitive behavioral therapySleep timeCocaine usersPolysomnographic sleepChronic cocaine usersCocaine-dependent participantsSubstance abuse treatmentThrice weekly urine toxicologyBehavioral therapyWeeks of abstinenceOverall sleep qualityAbuse treatmentDays abstinentDependent participantsREM sleep latencySleep qualityCocaine dependenceSlow-wave sleepAbstinenceMethylphenidate remediates error-preceding activation of the default mode brain regions in cocaine-addicted individuals
Matuskey D, Luo X, Zhang S, Morgan PT, Abdelghany O, Malison RT, Li CS. Methylphenidate remediates error-preceding activation of the default mode brain regions in cocaine-addicted individuals. Psychiatry Research 2013, 214: 116-121. PMID: 23973363, PMCID: PMC3811038, DOI: 10.1016/j.pscychresns.2013.06.009.Peer-Reviewed Original ResearchMeSH KeywordsAdultCentral Nervous System StimulantsCerebral CortexCocaine-Related DisordersCognition DisordersFemaleHumansImage Processing, Computer-AssistedInhibition, PsychologicalMagnetic Resonance ImagingMaleMethylphenidateMiddle AgedModels, NeurologicalNeural PathwaysNeuropsychological TestsOxygenPhotic StimulationReaction TimeConceptsFunctional magnetic resonance imagingStop-signal taskCD individualsCerebral activationPrecuneus/posterior cingulate cortexSystolic blood pressureInfluence of methylphenidateEffects of methylphenidateMagnetic resonance imagingPosterior cingulate cortexBrain imaging studiesCocaine-addicted individualsDefault mode networkAgonist therapyBlood pressureIntravenous methylphenidateCortico-striatoHealthy controlsCocaine-dependent individualsThalamic activationCingulate cortexResonance imagingBrain regionsMethylphenidateCocaine dependenceThe effects of exogenous progesterone on drug craving and stress arousal in cocaine dependence: Impact of gender and cue type
Fox HC, Sofuoglu M, Morgan PT, Tuit KL, Sinha R. The effects of exogenous progesterone on drug craving and stress arousal in cocaine dependence: Impact of gender and cue type. Psychoneuroendocrinology 2013, 38: 1532-1544. PMID: 23374328, PMCID: PMC3772967, DOI: 10.1016/j.psyneuen.2012.12.022.Peer-Reviewed Original ResearchMeSH KeywordsAdrenocorticotropic HormoneAdultAffectAlcohol DrinkingAnxietyArousalBlood PressureCocaine-Related DisordersComorbidityCuesDepressionDouble-Blind MethodEmotionsEstradiolFemaleHeart RateHumansHydrocortisoneHypothalamo-Hypophyseal SystemImagery, PsychotherapyMaleMiddle AgedPituitary-Adrenal SystemProgesteroneRelaxation TherapySex CharacteristicsSmokingStress, PsychologicalStroop TestConceptsDrug cravingCocaine-dependent menCognitive performanceStress arousalTreatment-seeking cocaine dependent individualsCue-induced cravingCocaine-dependent individualsCue typesStroop performanceSubjective cravingCognitive measuresImagery conditionNegative emotionsCue exposureInhibitory controlRelaxed moodDependent individualsDependent menArousal stateCravingArousalCounterbalanced orderStress exposureRewarding effectsCocaine dependence
2012
A single-day paradigm of self-regulated human cocaine administration
Matuskey D, Pittman B, Chen JI, Wanyiri J, Nadim H, Jatlow P, Gueorguieva R, Potenza MN, Morgan PT, Bhagwagar Z, Malison RT. A single-day paradigm of self-regulated human cocaine administration. Pharmacology Biochemistry And Behavior 2012, 103: 95-101. PMID: 22922558, PMCID: PMC3652339, DOI: 10.1016/j.pbb.2012.08.009.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlood PressureClinical ProtocolsCocaineCocaine-Related DisordersFemaleHeart RateHumansInfusion PumpsMaleMiddle AgedSelf AdministrationTime FactorsGuanfacine effects on stress, drug craving and prefrontal activation in cocaine dependent individuals: preliminary findings
Fox HC, Seo D, Tuit K, Hansen J, Kimmerling A, Morgan PT, Sinha R. Guanfacine effects on stress, drug craving and prefrontal activation in cocaine dependent individuals: preliminary findings. Journal Of Psychopharmacology 2012, 26: 958-972. PMID: 22234929, PMCID: PMC3694403, DOI: 10.1177/0269881111430746.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic alpha-2 Receptor AgonistsAdultCocaine-Related DisordersCombined Modality TherapyConnecticutDiagnostic and Statistical Manual of Mental DisordersDose-Response Relationship, DrugDouble-Blind MethodFemaleGuanfacineHumansImagery, PsychotherapyMagnetic Resonance ImagingMaleMiddle AgedNeuronsPilot ProjectsPrefrontal CortexStress, PsychologicalSubstance Withdrawal SyndromeConceptsCocaine-dependent individualsPrefrontal activityDrug cravingFunctional magnetic resonance imaging sessionDrug cue-induced cravingTreatment-seeking cocaine dependent individualsCue-induced drug cravingDependent individualsMagnetic resonance imaging sessionLateral prefrontal activityCue-induced cravingDrug cue exposureGuanfacine's effectsDrug cuesSubjective cravingImagery conditionPrefrontal activationCue exposurePhysiological arousalCognitive challengesBrain responsesAgonist guanfacineNicotine cravingGuanfacine groupCraving
2010
A multistudy analysis of the effects of early cocaine abstinence on sleep
Matuskey D, Pittman B, Forselius E, Malison RT, Morgan PT. A multistudy analysis of the effects of early cocaine abstinence on sleep. Drug And Alcohol Dependence 2010, 115: 62-66. PMID: 21144676, PMCID: PMC3081928, DOI: 10.1016/j.drugalcdep.2010.10.015.Peer-Reviewed Original ResearchBiological markers of the effects of intravenous methylphenidate on improving inhibitory control in cocaine-dependent patients
Li CS, Morgan PT, Matuskey D, Abdelghany O, Luo X, Chang JL, Rounsaville BJ, Ding YS, Malison RT. Biological markers of the effects of intravenous methylphenidate on improving inhibitory control in cocaine-dependent patients. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 14455-14459. PMID: 20660731, PMCID: PMC2922598, DOI: 10.1073/pnas.1002467107.Peer-Reviewed Original ResearchConceptsMiddle frontal cortexStop-signal reaction timeCocaine-dependent patientsWhole-brain linear regressionLonger stop-signal reaction timesFunctional MRI studyInhibitory controlInhibition-related activationBlood pressureIntravenous methylphenidatePeripheral biomarkersSignal reaction timeFrontal cortexStop-signal taskIndividualized treatmentHealthy individualsMRI studiesVentromedial prefrontal cortexSpecific neural mechanismsCocaine dependenceBiological markersPrefrontal cortexPatientsMethylphenidate responseSignal taskNormalizing Effects of Modafinil on Sleep in Chronic Cocaine Users
Morgan PT, Pace-Schott E, Pittman B, Stickgold R, Malison RT. Normalizing Effects of Modafinil on Sleep in Chronic Cocaine Users. American Journal Of Psychiatry 2010, 167: 331-340. PMID: 20080983, PMCID: PMC5857958, DOI: 10.1176/appi.ajp.2009.09050613.Peer-Reviewed Original ResearchMeSH KeywordsAdultBenzhydryl CompoundsCentral Nervous System StimulantsCocaineCocaine-Related DisordersDose-Response Relationship, DrugDouble-Blind MethodDrug Administration ScheduleHumansMaleMiddle AgedModafinilPolysomnographySleep Wake DisordersSubstance Abuse Treatment CentersSubstance Withdrawal SyndromeWakefulnessConceptsMultiple sleep latency testSlow-wave sleep timeSleep latency testEffects of modafinilTotal sleep timeSleep latencyCocaine-dependent participantsSleep timeChronic cocaine usersDaytime sleepinessLatency testCocaine usersShorter REM sleep latencyDaytime sleep latencyLonger total sleep timeREM sleep latencySubjective daytime sleepinessSleep architecture variablesPolysomnographic sleep recordingsSleep architectureNocturnal sleepHealthy comparison participantsAbstinent cocaine usersDay 1Day 2
2009
Sex differences in sleep and sleep-dependent learning in abstinent cocaine users
Morgan PT, Paliwal P, Malison RT, Sinha R. Sex differences in sleep and sleep-dependent learning in abstinent cocaine users. Pharmacology Biochemistry And Behavior 2009, 93: 54-58. PMID: 19379771, PMCID: PMC2699445, DOI: 10.1016/j.pbb.2009.04.006.Peer-Reviewed Original Research
2008
CLINICAL STUDY: Subjective responses and cardiovascular effects of self‐administered cocaine in cocaine‐abusing men and women
Lynch WJ, Kalayasiri R, Sughondhabirom A, Pittman B, Coric V, Morgan PT, Malison RT. CLINICAL STUDY: Subjective responses and cardiovascular effects of self‐administered cocaine in cocaine‐abusing men and women. Addiction Biology 2008, 13: 403-410. PMID: 18782384, PMCID: PMC3690939, DOI: 10.1111/j.1369-1600.2008.00115.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultBody WeightCardiovascular DiseasesCocaine-Related DisordersElectrocardiographyFemaleHospitalizationHumansMaleMiddle AgedSelf AdministrationSex DistributionYoung AdultConceptsSelf-administer cocaineSelf-administered cocaine infusionsDiastolic blood pressureSubjective effect measuresCocaine-induced increasesCocaine self-administration sessionsFeelings of hungerFixed ratio 1Cocaine-abusing menSelf-administration sessionsTime-dependent increaseCardiovascular effectsBlood pressureCardiovascular responsesHormonal influencesCocaine abuseSecondary analysisCocaine infusionsHuman laboratoryCardiovascular measuresEffect measuresWomenCocaineMenSignificant main effectSleep architecture, cocaine and visual learning
Morgan PT, Pace‐Schott E, Sahul ZH, Coric V, Stickgold R, Malison RT. Sleep architecture, cocaine and visual learning. Addiction 2008, 103: 1344-1352. PMID: 18855824, PMCID: PMC3690941, DOI: 10.1111/j.1360-0443.2008.02233.x.Peer-Reviewed Original ResearchConceptsChronic cocaine usersVisual learningProgressive abstinenceVisual texture discrimination taskLate night REM sleepSlow wave activityAbstinence-related changesTexture discrimination taskCocaine usersSleep architectureCocaine useVisual performanceREM sleepOvernight enhancementDays of abstinenceDiscrimination taskCocaine self-administration sessionsSelf-administration sessionsCognitive functionChronic cocaine useLearning deficitsCognitive dysfunctionRapid eye movement (REM) sleepAbstinenceCocaine abstinenceChest Tightness and Palpitations Associated With Modafinil and Consumption of Free Glutamate
MORGAN PT, MALISON RT. Chest Tightness and Palpitations Associated With Modafinil and Consumption of Free Glutamate. American Journal Of Psychiatry 2008, 165: 538-538. PMID: 18381922, DOI: 10.1176/appi.ajp.2007.07040717.Peer-Reviewed Original ResearchCocaine Users Differ from Normals on Cognitive Tasks Which Show Poorer Performance During Drug Abstinence
Pace-Schott EF, Morgan PT, Malison RT, Hart CL, Edgar C, Walker M, Stickgold R. Cocaine Users Differ from Normals on Cognitive Tasks Which Show Poorer Performance During Drug Abstinence. The American Journal Of Drug And Alcohol Abuse 2008, 34: 109-121. PMID: 18161649, DOI: 10.1080/00952990701764821.Peer-Reviewed Original ResearchConceptsVerbal recognition memoryCocaine usersCocaine-dependent individualsCocaine-induced impairmentRecognition memoryCognitive tasksCognitive batteryCognitive changesDrug-free baselineDrug abstinenceAbstinencePoor performanceMemoryCocaine useDrug useDay cocaineNormative valuesAttentionCocaineTaskImpairmentIndividualsBatteriesInpatient study